Pieter W Kamphuisen,Tjeerd G Wiersma,Chris J J Mulder et al.
Pieter W Kamphuisen et al.
In liver cirrhosis coagulation is impaired due to decreased synthesis of vitamin K-dependent and vitamin K-independent coagulation factors. In such patients routine liver biopsy is contraindicated due to the increased risk of bleeding. Trea...
Impaired flow-mediated vasodilation in vivo and reduced shear-induced platelet reactivity in vitro in response to nitric oxide in prothrombotic, stroke-prone spontaneously hypertensive rats [0.03%]
Tomomi Taka,Yoshio Ohta,Junji Seki et al.
Tomomi Taka et al.
Previous investigations using an He-Ne laser-induced thrombosis method have shown that stroke-prone spontaneously hypertensive rats (SHRSP) have an enhanced thrombotic tendency in vivo compared to normotensive, Wistar Kyoto rats (WKY). In a...
New method for the extraction of DNA from white blood cells for the detection of common genetic variants associated with thrombophilia [0.03%]
Antonio Angelini,Concetta Di Febbo,Agnese Rullo et al.
Antonio Angelini et al.
In the last few years, FV Leiden, prothrombin 20210 and thermolabile methylene tetrahydrofolate reductase (MTHFR) 677 variants have been identified as possible risk factors associated with thrombophilia, and many PCR-based methods have been...
Effect of phenprocoumon on monitoring of lepirudin, argatroban, melagatran and unfractionated heparin with the PiCT method [0.03%]
T Fenyvesi,I Jörg,J Harenberg
T Fenyvesi
Prothrombinase-induced clotting time (PiCT) is a clotting-time test for heparins and direct thrombin inhibitors to reduce drawbacks of aPTT. Effects of the direct thrombin inhibitors lepirudin, argatroban, melagatran and of unfractionated h...
Bound thrombin from crushed clots is composed of alpha-thrombin and the N-terminal regions of alpha- and gamma-chains of fibrinogen [0.03%]
Kiyohiko Kinjoh,Mariko Nakamura,Zeng Gang et al.
Kiyohiko Kinjoh et al.
We aimed at clarifying the structural characteristics of the bound thrombin that is liberated by mechanical breakdown of fibrin clots. Fibrin clots were prepared with bovine thrombin and rabbit fibrinogen, and were crushed mechanically with...
Alterations of thrombogenesis, endothelial damage and oxidative stress with reperfusion during femoral artery bypass surgery for peripheral vascular disease [0.03%]
Andrew J Makin,Natali A Y Chung,Stanley H Silverman et al.
Andrew J Makin et al.
Peripheral vascular disease (PVD) is a significant cause of cardiovascular morbidity. We hypothesised that there would be significant alterations of thrombogenesis, platelet activation and endothelial damage, which could be associated with ...
Effect of low-dose aspirin on the international normalized ratio variability in patients with mechanical heart valve prostheses [0.03%]
Patricia Casais,Susana S Meschengieser,Analia G Sanchez Luceros et al.
Patricia Casais et al.
An increased risk of bleeding is associated with a more intense oral anticoagulation, a greater international normalized ratio (INR) variability and the use of aspirin. We studied the INR variability of patients (n = 121) with modern heart ...
Barbara Salobir,Miso Sabovic,Polona Peternel
Barbara Salobir
In a prospective study, which lasted 1 year and was performed on a large cohort of 800 patients treated at an outpatient anticoagulant clinic, we investigated possible seasonal variations in the intensity of the effect of warfarin treatment...
Quantification of antithrombin isoform proportions in plasma samples of healthy subjects, sepsis patients, and in antithrombin concentrates [0.03%]
健康受试者、败血症患者血浆及抗凝血酶制品中抗凝血酶各亚型的比例定量分析
Jürgen Römisch,Reiner Dönges,Harald Stauss et al.
Jürgen Römisch et al.
Antithrombin (AT) circulates in plasma in two isoforms, AT-alpha (90-95%) and AT-beta (5-10%). AT isoform proportions were measured in plasma samples of 17 healthy subjects and 26 posttraumatic or postoperative septic patients, as well as i...