Targeting the endothelium in cancer--the importance of the interaction of hemostatic mechanisms and the vascular wall for tumor growth and angiogenesis [0.03%]
针对内皮细胞的癌症治疗——凝血机制与血管壁相互作用在肿瘤生长和血管生成中的重要性
Frederick R Rickles,Steven R Patierno,Patricia M Fernandez
Frederick R Rickles
Thrombin generation in platelet-rich plasma as a tool for the detection of hypercoagulability in young stroke patients [0.03%]
富含血小板血浆中凝血酶生成与青年卒中患者高凝状态的关系研究
C G Faber,J Lodder,F Kessels et al.
C G Faber et al.
The time course of the concentration of active thrombin in clotting plasma (the thrombogram) was measured by subsampling from platelet-rich plasma (PRP) and continuous chromogenic measurement of platelet-poor plasma (PPP) in 41 stroke patie...
A critical evaluation of the prothrombin time for monitoring oral anticoagulant therapy [0.03%]
口服抗凝治疗中以凝血酶原时间进行监测的评价研究
Craig M Jackson,M Peter Esnouf,Tomas L Lindahl
Craig M Jackson
The Quick prothrombin time is the most common clotting test performed, principally for monitoring oral anticoagulant therapy. The International Normalized Ratio (INR) for comparing patient results from prothrombin time measurements and the ...
Thrombin generation measurement in factor VII-depleted plasmas compared to inherited factor VII-deficient plasmas [0.03%]
因子VII缺乏对血浆凝血酶生成的影响与遗传性因子VII缺乏的比较研究
Muriel Giansily-Blaizot,Raed Al Dieri,Jean-François Schved
Muriel Giansily-Blaizot
Activated factor VII (FVIIa)/tissue factor enzyme complex is the initiator of the coagulation cascade in vivo. FVIIa is of particular interest because it has been found to induce haemostasis in various bleeding disorders. In order to evalua...
Comparative Study
Pathophysiology of haemostasis and thrombosis. 2003;33(1):36-42. DOI:10.1159/000071640 2003
Thrombin generation in platelet-poor plasma is normal in patients with hereditary mucocutaneous haemorrhages [0.03%]
血小板减少患者的凝血酶生成正常
Teresa Quiroga,Manuela Goycoolea,Peter L A Giesen et al.
Teresa Quiroga et al.
Mild hereditary bleeding disorders presenting with mucocutaneous haemorrhages are usually difficult to diagnose. We measured thrombin generation in platelet-poor plasma (TG-PPP) in 206 patients with a clinically unequivocal bleeding tendenc...
Calibrated automated thrombin generation in frozen-thawed platelet-rich plasma to detect hypercoagulability [0.03%]
用于检测高凝状态的冷冻解冻血小板浓缩悬液校准的自动化凝血酶生成测定法
Véronique Regnault,Suzette Béguin,Thomas Lecompte
Véronique Regnault
To enhance the practical applicability of the calibrated automated thrombogram (CAT) we investigated whether frozen-thawed platelet-rich plasma (ft-PRP) can be used to assess the function of the protein C inhibitory pathway, while preservin...
Factor VIII inhibitor-bypassing agents act by inducing thrombin generation and can be monitored by a thrombin generation assay [0.03%]
第八因子抑制剂绕过药物通过诱导凝血酶生成而起作用，并可通过凝血酶生成试验进行监测
P L Turecek,K Váradi,B Keil et al.
P L Turecek et al.
Factor VIII (FVIII)-bypassing agents have complex modes of action but all control bleeding in inhibitor patients by triggering the generation of thrombin. No routine test is available for monitoring this therapy in patients with inhibitors ...
H Coenraad Hemker,Peter Giesen,Raed Al Dieri et al.
H Coenraad Hemker et al.
Calibrated automated thrombography displays the concentration of thrombin in clotting plasma with or without platelets (platelet-rich plasma/platelet-poor plasma, PRP/PPP) in up to 48 samples by monitoring the splitting of a fluorogenic sub...
Louis M Aledort
Louis M Aledort
Intervention for clotting and bleeding disorders is costly, and clear-cut regimens undefined. The margin of safety between hemostasis and thrombosis is narrow and unpredictable. The use of a laboratory test to help define therapeutic regime...
Jawed Fareed,Debra Hoppensteadt,Omer Iqbal et al.
Jawed Fareed et al.
Argatroban was the very first antithrombin agent that was approved for clinical use. It represents a synthetic arginomimetic drug with multiple pharmacologic properties. Unlike other antithrombin drugs, argatroban is a reversible antithromb...