Francisco España,Pilar Medina,Silvia Navarro et al.
Francisco España et al.
The protein C (PC) anticoagulant pathway plays a crucial role in the regulation of fibrin formation via proteolytic degradation of the procoagulant cofactors factor Va and VIIIa by activated PC (APC). PC circulates in plasma as a zymogen, w...
Advances in the genotyping of thrombosis genetic risk factors: clinical and laboratory implications [0.03%]
血栓形成遗传危险因素基因分型的进展及其临床和实验意义
José Manuel Cabeda,Mónica Pereira,José Miguel Oliveira et al.
José Manuel Cabeda et al.
Since FV-Leiden polymorphism was first described in 1994, a growing number of polymorphic loci have been identified in association with increased genetic risk for thrombophilia. Often however, these risk factors have been studied in isolati...
Pathogenesis of the acute coronary syndromes and therapeutic implications [0.03%]
急性冠脉综合征的发病机制及其治疗意义
L Badimon,J J Badimon,G Vilahur et al.
L Badimon et al.
Atherosclerosis is characterized by the thickening and obstruction of the arterial lumen and thrombosis associated with vulnerable disrupted plaques seems to be responsible for the accelerated process of clinical syndrome presentation. Stra...
Meyer Michel Samama,Grigoris T Gerotziafas,Ismail Elalamy et al.
Meyer Michel Samama et al.
New anticoagulants have been designed using advances in the biotechnology and the biochemistry of the clotting factors. They are classified according to their target or their mechanism of action (AT-dependent or AT-independent). Antithrombo...
Glanzmann thrombasthenia: a model disease which paved the way to powerful therapeutic agents [0.03%]
Glanzmann血小板病：一种模式疾病，为有效治疗药物的开发铺平了道路
Uri Seligsohn
Uri Seligsohn
Glanzmann thrombasthenia (GT) is an autosomal recessive bleeding disorder characterized by deficient or dysfunctional glycoprotein (GP) IIb/IIIa compexes. The hallmark of the disease is impaired platelet aggregation stemming from defective ...
David A Lane,Luigina R Mollica
David A Lane
Haemostatic gene polymorphisms are potential risk factors for thrombosis. Considerable attention has been focussed on identifying risk alleles. Progress has undoubtedly been made in venous thrombosis. Factor V Leiden and the prothrombin G20...
P M Mannucci
P M Mannucci
Venous thrombosis is a frequent disease. It is surprising, therefore, that no case truly compatible with a diagnosis of venous thrombosis was apparently reported in the antiquity. There is no case that could be reasonably attributed to a ve...
Ajay K Kakkar
Ajay K Kakkar
James P Quigley
James P Quigley