C Kluft
C Kluft
The deposition of the insoluble protein matrix, fibrin is temporary. The mainly known mechanism of proteolytic removal is orchestrated by a cascade type of proteolytic process involving ultimately the formation from plasminogen of the activ...
The von Willebrand factor-cleaving protease (ADAMTS-13) and the diagnosis of thrombotic thrombocytopenic purpura (TTP) [0.03%]
von Willebrand因子裂解蛋白酶(ADAMTS-13)与血栓性血小板减少性紫癜的诊断关系
Johanna A Kremer Hovinga,Jan-Dirk Studt,Bernhard Lämmle
Johanna A Kremer Hovinga
Thrombotic thrombocytopenic purpura (TTP) is a life threatening disorder characterized by microangiopathic hemolytic anemia and thrombocytopenia as a result of microvascular platelet clumping often accompanied by ischemic organ dysfunctions...
Trombocytopenia: one of the markers of disseminated intravascular coagulation [0.03%]
血小板减少是弥散性血管内凝血的一个标志
Hugo Ten Cate
Hugo Ten Cate
Disseminated intravascular coagulation (DIC) is a complication of a variety of severe underlying diseases and a contributing factor in multi-organ failure and death. DIC is diagnosed on the basis of clinical findings (organ failure, bleedin...
New developments in diagnosis and treatment of heparin-induced thrombocytopenia [0.03%]
肝素诱导的血小板减少症的诊断和治疗新进展
Norbert Lubenow
Norbert Lubenow
Heparin-induced thrombocytopenia (HIT) is a drug induced immune mediated thrombocytopenia that affects up to 3% of patients treated with unfractionated heparin (UFH). It is less frequent when low molecular weight heparins (LMWH) are used. F...
Trevor Baglin
Trevor Baglin
Testing for laboratory evidence of heritable thrombophilia is now common. This practice undoubtedly arose in response to association studies, which revealed the influence of heritable thrombophilic defects on the development of VTE. Now tha...
Rogier M Bertina
Rogier M Bertina
Increased plasma levels of fibrinogen, factor VIII (FVIII), factor IX (FIX), factor XI (FXI) and prothrombin all were reported to be independent risk factors of venous thromboembolism (VTE). However there is only limited information on the ...
Anna Falanga
Anna Falanga
Hemostatic mechanisms play a role not only in cancer associated thrombotic diathesis, but also in tumor growth and dissemination. Hence, inhibition of fibrin formation has been considered a possible tool against the progression of malignant...
Plasma thrombin-activatable fibrinolytic inhibitor (TAFI) among healthy subjects and patients with vascular diseases: a validation study [0.03%]
健康人群和血管病患者血浆中可被凝血酶激活纤溶抑制剂(TAFI)的验证性研究
J Monasterio,P Bermúdez,D Quiroga et al.
J Monasterio et al.
Thrombin activable fibrinolysis inhibitor antigen levels (TAFI Ag ) exhibit a great inter-individual variability in healthy populations. Our aim is to determine whether variability is due to physiologic variations depending on genetic contr...
Thrombin activatable fibrinolysis inhibitor (TAFI) at the interface between coagulation and fibrinolysis [0.03%]
凝血和纤维蛋白溶解之间的界面处的凝血酶激活纤溶抑制物(TAFI)
Bonno N Bouma,Laurent O Mosnier
Bonno N Bouma
The thrombin-catalysed conversion of plasma fibrinogen into fibrin and the development of an insoluble fibrin clot are the final steps of the coagulation cascade during haemostasis. A delicate balance between coagulation and fibrinolysis de...
C Manotti,C Pattacini,R Quintavalla et al.
C Manotti et al.
The constantly workload increase has led to the development of Computerised Decision Support Systems (CDSS) for a better management of patient care. Many clinical situations have been investigated to verify the utility of CDSS: few have dem...