Danijel Kikelj
Danijel Kikelj
The central position of thrombin in the coagulation cascade has made it a popular target for discovery of novel antithrombotic agents. Starting with hirudin, a natural peptide isolated from the medicinal leech, its shorter synthetic analogu...
Patricia B Maguire
Patricia B Maguire
The integration of proteomics into biochemical and biological investigation has proved a powerful tool in understanding the anucleate platelet. Over the past few years, various approaches have been used to document platelet proteins and her...
Haemostatic cardiovascular risk factors: differential effects of red wine and diet on healthy young [0.03%]
血管危险因素的止血作用：红葡萄酒和饮食对健康年轻人的不同影响
Diego Mezzano,Federico Leighton
Diego Mezzano
Two groups (21 healthy young male each) received either Mediterranean-type diet (MD) or high-fat diet(HFD) during 90 days. Between days 30-60, both diets were supplemented with 240 ml/day of red wine. MD alone was associated with: lower pla...
The mediterranean lecture: wine and thrombosis--from epidemiology to physiology and back [0.03%]
地中海讲座：酒和血栓由流行病学到生理学再回到流行病学
Giovanni de Gaetano,Augusto Di Castelnuovo,Maria B Donati et al.
Giovanni de Gaetano et al.
The protective effect of moderate alcohol consumption on the risk of cardiovascular disease has been consistently shown in many epidemiological studies. Antiatherogenic alterations in plasma lipoproteins, particularly increase in high-densi...
L Serra-Majem,J Ngo de la Cruz,L Ribas et al.
L Serra-Majem et al.
Objective: The purpose of this study was to review and analyze the synergies of olive oil related food consumption and nutrient intake in a Mediterranean region. ...
Gordon D O Lowe
Gordon D O Lowe
Virchow rightly recognised that blood flow plays an important role in thrombosis. The roles of blood flow in haemostasis, and in arterial, intra-cardiac, and venous thrombosis are reviewed. In streamline (laminar) flow, shear stresses are m...
Irene Chung,Gregory Y H Lip
Irene Chung
An update of Virchow's triad for thrombogenesis can be considered by reference to abnormalities in the endothelium/endocardium ('abnormal vessel wall'), abnormalities of haemorhelogy and turbulence at bifurcations,atheroma at vessel wall ('...
Andrew D Blann
Andrew D Blann
In order to maintain an anticoagulant nature, the healthy endothelium secretes factors such as tissue plasminogen activator, ADPase, and expresses membrane thrombomodulin. However, when damaged, it releases increased amounts of pro-coagulan...
New aspects in thrombotic research: complement induced switch in mast cells from a profibrinolytic to a prothrombotic phenotype [0.03%]
血栓研究新进展：补体诱导的肥大细胞从促纤维蛋白溶解向促凝转变的新机制
Johann Wojta,Kurt Huber,Peter Valent
Johann Wojta
Mast cells, strategically located in the vicinity of blood vessels, are multifunctional effector cells participating in the modulation of various inflammatory and cardiovascular disease processes by actively releasing a wide variety of vaso...
Fibrin stabilization (factor XIII), fibrin structure and thrombosis [0.03%]
纤维蛋白稳定(因子XIII)、纤维蛋白结构和血栓形成
Zsuzsanna Bereczky,Eva Katona,László Muszbek
Zsuzsanna Bereczky
Factor XIII (FXIII) is a zymogen that is converted into an active transglutaminase (FXIIIa) by the concerted action of thrombin and Ca2+. Its main task is to crosslink alpha-, and gamma-chains of fibrin and alpha2-plasmin inhibitor to fibri...