Endothelin Receptor Blockade Improves Cerebral Blood Flow-Mediated Dilation in a Mouse Model of Alzheimer's Disease [0.03%]
内皮素受体阻断改善阿尔茨海默病小鼠模型的脑血管血流介导扩张反应
Daniel Henrion,Philippe Bonnin,Emilie Vessieres et al.
Daniel Henrion et al.
Introduction: Cerebral blood flow (CBF) is reduced in patients with Alzheimer's disease (AD). Flow-mediated dilation (FMD), which plays a key role in the regulation of blood flow, is attenuated by endothelin-1. We hypothe...
Protease-Activated Receptor 2 Controls Vascular Smooth Muscle Cell Proliferation in Cyclic AMP-Dependent Protein Kinase/Mitogen-Activated Protein Kinase Kinase 1/2-Dependent Manner [0.03%]
蛋白酶激活受体2通过环AMP依赖的蛋白激酶/丝裂原活化蛋白激酶激酶1/2控制血管平滑肌细胞增殖
Madison D Williams,Michael T Bullock,Sean C Johnson et al.
Madison D Williams et al.
Introduction: Cardiovascular disorders are characterized by vascular smooth muscle (VSM) transition from a contractile to proliferative state. Protease-activated receptor 2 (PAR2) involvement in this phenotypic conversion...
Regulation of Skeletal Muscle Resistance Arteriolar Tone: Integration of Multiple Mechanisms [0.03%]
整合多种机制调节骨骼肌阻力 arterioles 的张力
Brayden D Halvorson,Yuki Bao,Aaron D Ward et al.
Brayden D Halvorson et al.
Introduction: Physiological system complexity represents an imposing challenge to gaining insight into how arteriolar behavior emerges. Further, mechanistic complexity in arteriolar tone regulation requires that a systema...
Cx43 Facilitates Mesenchymal Transition of Endothelial Cells Induced by Shear Stress [0.03%]
缝隙连接蛋白Cx43介导剪切应力诱导的内皮细胞间质转化的作用及机制研究
En Zhou,Jing Zhou,Changlong Bi et al.
En Zhou et al.
Objectives: This study aimed to determine the function of Cx43 in the endothelial-to-mesenchymal transition (EndMT) process of endothelial cells (ECs) and to explore the potential signaling pathways underlying these funct...
Emodin Inhibits the Indoxyl Sulfate-Induced trans-Differentiation of Vascular Smooth Muscle Cells through Upregulating Thrombospondin-1 [0.03%]
大黄素通过上调血小板反应蛋白-1抑制吲哚硫酸盐诱导的血管平滑肌细胞转分化作用
Weidong Zhang,Jing Chen,Xiao Tan et al.
Weidong Zhang et al.
Background: Indoxyl sulfate (IS) is a protein-bound uremic toxin with vascular toxicity. The primary cause of death in uremic patients on maintenance hemodialysis is vascular disease, and it had been reported that vascula...
RhoA/ROCK Signaling Is Involved in Pathological Retinal Neovascularization [0.03%]
RhoA/ROCK信号参与病理性的视网膜新生血管形成
Fen Tang,Kongqian Huang,Biyan Peng et al.
Fen Tang et al.
Objective: The aim of the study was to evaluate the effect of the RhoA/ROCK inhibitor Fasudil on retinal neovascularization (NV) in vivo and angiogenesis in vitro. ...
Isolation and Cultivation of Vascular Smooth Muscle Cells from the Mouse Circle of Willis [0.03%]
小鼠Willis环血管平滑肌细胞的分离与培养
Wei Chang,Yajuan Li,Fengzhou Liu et al.
Wei Chang et al.
Introduction: Culturing cerebrovascular smooth muscle cells (CVSMCs) in vitro can provide a model for studying many cerebrovascular diseases. This study describes a convenient and efficient method to obtain mouse CVSMCs b...
A Preliminary Discussion on the Safety of Mild Therapeutic Hypothermia in Target Vessels after Endovascular Intervention in Acute Large Vessel Occlusion Cerebral Infarction [0.03%]
急性大血管闭塞脑梗死血管内治疗后目标血管轻度治疗性亚低温安全性的初步探讨
Jiang Li,Shaonian Tang,Juanli Liu et al.
Jiang Li et al.
Introduction: The aim of this study was to discuss the safety of rapid administration of 4°C hypothermic normal saline into the occluded vessels using an intra-arterial catheter to induce mild hypothermia following endov...
FNDC5 Attenuates Atherosclerotic Plaque Formation and Regulates PPARα/HO-1 in ApoE-/- Mice [0.03%]
FNDC5抑制载脂蛋白E基因敲除小鼠动脉粥样硬化斑块形成并调节PPARα/HO-1功能
Bo Zhou,Xiang Wang,Yao Wang et al.
Bo Zhou et al.
Introduction: This study attempted to observe the role of fibronectin type III domain-containing protein 5 (FNDC5) in atherosclerosis development and the underlying mechanism. ...
Timothy M Sveeggen,Anna Kosmach,Pooneh Bagher
Timothy M Sveeggen