Molecular Characterization of Influenza A(H3N2) Hemagglutinin Variants Circulating in Western Mexico, 2022 [0.03%]
墨西哥西部2022年流行的流感A(H3N2)血凝素变异株的分子特征分析
Karen M Hernandez-Gonzalez,Ahtziri Socorro Carranza-Aranda,José Francisco Muñoz-Valle et al.
Karen M Hernandez-Gonzalez et al.
Influenza A(H3N2) remains a significant public health threat due to its rapid antigenic drift, which often compromises vaccine effectiveness. This study characterized the molecular and epidemiological profile of hemagglutinin (HA) variants ...
Role of Regulated Cell Death Pathways in Snakebite Envenomation: Mechanisms, Crosstalk, and Therapeutic Opportunities [0.03%]
毒蛇咬伤中调控性细胞死亡途径的作用：机制、相互作用及治疗机会
Aswathy Alangode,Adithyan Rajasekhar,Jyotsna J Sabu et al.
Aswathy Alangode et al.
Snakebite envenomation causes severe tissue damage, often resulting in permanent disability with long-term complications like amputations and organ dysfunction. Current antivenoms, which are antibody-based, have lower tissue penetrability a...
Role of Regulated Cell Death Pathways in Snakebite Envenomation: Mechanisms, Crosstalk, and Therapeutic Opportunities [0.03%]
毒蛇咬伤中调控性细胞死亡途径的作用：机制，相互作用及治疗机会
Aswathy Alangode,Adithyan Rajasekhar,Jyotsna J Sabu et al.
Aswathy Alangode et al.
Snakebite envenomation causes severe tissue damage, often resulting in permanent disability with long-term complications like amputations and organ dysfunction. Current antivenoms, which are antibody-based, have lower tissue penetrability a...
PDGF-Stimulated Corneal Keratocyte Motility and Migration Patterns on Aligned Collagen Fibrils Are Inhibited by Decorin [0.03%]
decorin抑制PDGF刺激的角膜基质细胞运动和规则排列胶原纤维上的迁移模式
Nathaniel S Tjahjono,Divya Subramanian,Tarik Z Shihabeddin et al.
Nathaniel S Tjahjono et al.
Decorin, a proteoglycan shown to inhibit transforming growth factor β1 (TGF-β1) signaling, has been increasingly considered as a potential anti-fibrotic agent to aid in therapies addressing corneal scarring and blindness. Decorin is also ...
Coordinated MBW, GIS, and RSL Regulatory Networks in Plant Epidermal Patterning Under Environmental Cues [0.03%]
环境信号调控表皮细胞模式形成的MBW、GIS和RSL协同网络
Muhammad Umair Yasin,Zulqarnain Haider,Irshan Ahmad et al.
Muhammad Umair Yasin et al.
The plant epidermis, adorned with trichomes and root hairs, represents a critical interface where developmental programming and environmental responses converge. Although the genetic basis of epidermal patterning has been extensively charac...
Coordinated MBW, GIS, and RSL Regulatory Networks in Plant Epidermal Patterning Under Environmental Cues [0.03%]
环境线索下植物表皮图式形成过程中MBW、GIS和RSL调控网络的协调作用
Muhammad Umair Yasin,Zulqarnain Haider,Irshan Ahmad et al.
Muhammad Umair Yasin et al.
The plant epidermis, adorned with trichomes and root hairs, represents a critical interface where developmental programming and environmental responses converge. Although the genetic basis of epidermal patterning has been extensively charac...
Identification of Natural Flavonoids Targeting PLK-1 as Potential Anti-Metastatic Agents: A Computational Approach [0.03%]
基于计算的天然黄酮类化合物作为PLK-1靶向抗转移剂的研究
Yudith Cañizares-Carmenate,Erix W Hernández-Rodríguez,Yunier Perera-Sardiña et al.
Yudith Cañizares-Carmenate et al.
This study combines ligand- and structure-based in silico strategies to predict the inhibitory activity of natural flavonoids on the Polo-Like Kinase-1 (PLK-1) enzyme as candidate anticancer agents. This enzyme participates in mitosis and i...
Berberine Alleviates Citrobacter rodentium-Induced Colitis with Reduced Epithelial Gasdermin E-Mediated Pyroptosis [0.03%]
番红花素通过减少上皮Gasdermin E介导的焦亡来缓解Citrobacter rodentium诱导的结肠炎
Meiqi Zhang,Sixian Wei,Zheng Luo et al.
Meiqi Zhang et al.
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the intestine. Although current therapies can provide symptomatic relief, they are often associated with high costs and adverse effects. Coptis chinensis Franch., a tra...
Identifying Epithelial-Cell Progression Signatures (ECPSs) from Multi-Resolution Multi-Omics Data for Translational Clinical Applications in Lung Adenocarcinoma [0.03%]
基于多分辨率多组学数据识别肺腺癌上皮细胞进展标志物(ECPS)，用于转化医学临床应用
Xueyao Chen,Tongxin Lv,Yang Wu et al.
Xueyao Chen et al.
Dynamic transcriptomic remodeling of epithelial cells represents a critical hallmark of lung adenocarcinoma (LUAD) progression, yet epithelial-cell progression signatures (ECPSs) linked to this process remain incompletely characterized, imp...
The Gut-Brain-Skin Axis: Systemic Effects of Functional Ingredients in Healthy Skin Aging [0.03%]
皮肤-大脑-肠道轴系：功能成分对健康皮肤老化的作用
Yeojin Kim,Sung-Joon Lee
Yeojin Kim
Interactions among the gut, brain, and skin are increasingly understood as a systemic regulatory network connecting intestinal activity, neuroimmune communication, and cutaneous homeostasis. Microbiota-derived metabolites, immune mediators,...