Peptide-Based Nanocomplexes Enable Transferrin-Mediated Uptake and p53-Driven Antitumor Activity in 2D and 3D Glioblastoma Models [0.03%]
基于肽的纳米复合物能够介导转铁蛋白摄取和p53驱动的抗肿瘤活性在二维和三维胶质母细胞瘤模型中
Leonor M Castro,Ana R Neves,Eric Vivès et al.
Leonor M Castro et al.
Glioblastoma (GB), the most prevalent and aggressive brain tumor, remains one of the most lethal challenges in modern oncology. Standard therapy remains largely ineffective, mainly due to limited therapeutic penetration across the blood-bra...
Freeze-Dried CS/PVP/PVA Composite Scaffolds Doped with Curcumin and SiO2 Nanoparticles for Tissue Regeneration [0.03%]
掺有Curcumin和SiO2纳米颗粒的CS/PVP/PVA复合支架的冻干制品用于组织再生
Domingo Cesar Carrascal-Hernández,Jairo Ortiz,Alexander Córdoba et al.
Domingo Cesar Carrascal-Hernández et al.
In this study, three formulations (F1, F2, and F3) were developed to fabricate hybrid scaffolds composed of chitosan (CS), polyvinylpyrrolidone (PVP), and polyvinyl alcohol (PVA), doped with curcumin (CUR) and silicon dioxide nanoparticles ...
From Metal-Related Public Health Risks to Bioremediation: The Potential of the Polyextremophilic Galdieria spp.-A Systematic Review [0.03%]
从金属相关的公共健康风险到生物修复：耐极端环境的Galdieria菌株的潜力——系统性综述
Elio Pozzuoli,Concetta Auciello,Salvatore Avilia et al.
Elio Pozzuoli et al.
The growing demand for rare earth elements (REEs), heavy metals (HMs) and precious metals (PMs) has intensified interest in sustainable recovery strategies from secondary resources, including mining residues, industrial effluents and waste ...
Modeling Inherited Disorders of Post-Lanosterol Cholesterol Biosynthesis: From Animal Models to Patient-Derived Stem Cells [0.03%]
法尼醇后胆固醇生物合成遗传病的模型建立：从动物模型到患者诱导干细胞
Elvira Akhmetzyanova,Evelina Nasybullina,Albert Rizvanov et al.
Elvira Akhmetzyanova et al.
Altered post-lanosterol cholesterol biosynthesis causes a heterogeneous group of rare inherited metabolic disorders, including Smith-Lemli-Opitz syndrome, desmosterolosis, lathosterolosis, and congenital hemidysplasia with ichthyosiform nev...
Asparagine-Guided Regulation of Redox Status and Autophagy in Sugar-Starved Lupin (Lupinus spp.) Embryonic Axes-A Transcriptomic and Proteomic Approach [0.03%]
天冬酰胺结合低糖胁迫下苜蓿轴红色状态和自噬的调节-转录组及蛋白组学方法研究
Szymon Stefaniak,Karolina Wleklik,Katarzyna Nuc et al.
Szymon Stefaniak et al.
Sugar starvation during seed germination requires coordinated regulation of reserve mobilization, redox homeostasis, and intracellular recycling. In lupin seeds, asparagine is a major nitrogen-rich metabolite, but its role in starvation-ind...
Type 1 Diabetes Mellitus as a Model of Body Composition Transformation: Pathogenetic Unity of Combined Phenotypes [0.03%]
1型糖尿病 mellitus 作为身体组成转化模型：结合表型病理基因统一性
Regina Gizatullina,Karina Akhiiarova,Ildar Minniakhmetov et al.
Regina Gizatullina et al.
The study of body composition (BC) is of increasing clinical and research relevance, as it provides a detailed characterization of metabolic status beyond traditional anthropometric indices such as body mass index (BMI). BC describes the qu...
Fast Microbiology: A Pilot Study Comparing Culture-Independent Digital PCR and Blood Culture for Pathogen Detection in Sepsis [0.03%]
快速微生物学：一项针对败血症病原体检测的无培养数字PCR与血培养比较的研究
Maria Vittoria Ristori,Tiziana Marfoli,Marina De Cesaris et al.
Maria Vittoria Ristori et al.
Bloodstream infections (BSIs) represent a major clinical challenge, particularly in patients with suspected sepsis, where rapid pathogen identification is critical for timely and appropriate antimicrobial therapy. Blood culture (BC) remains...
AAV Vectors in Regenerative Medicine and Cellular Reprogramming: Potential, Pitfalls, and Specificity Constraints [0.03%]
腺相关病毒载体在再生医学和细胞重编程中的应用：潜力、困境及特异性限制
Mariam Abdelnaby,Adelya Galiakberova,Erdem Dashinimaev
Mariam Abdelnaby
The adeno-associated virus (AAV) has become the vector of choice for gene therapy and experimental gene delivery, owing to its non-pathogenic nature and ability to achieve persistent gene expression across diverse tissues. AAV has emerged a...
Moranoline-Enriched Bacillus velezensis AmoreLumina Culture Extract Attenuates Post-Inflammatory Hyperpigmentation in Acne-Prone Skin [0.03%]
摩拉鲁明（moranolines）富集的枯草芽孢杆菌（Bacillus velezensis AmoreLumina）发酵产物可改善炎后色素沉着及痤疮受损皮肤
Daejin Min,Hyuk Kim,Eun-Jeong Choi et al.
Daejin Min et al.
Post-inflammatory hyperpigmentation (PIH) results from inflammatory responses that leave persistent dark spots around pores after acne lesions are resolved. This pigmentation is caused by increased melanogenesis in melanocytes stimulated by...
Mechanism of Terpene Formation in Pogostemon cablin cv. Jing Huoxiang Revealed by Metabolome and Transcriptome Analysis [0.03%]
代谢组和转录组联合揭示薄荷醇中萜类化合物的形成机制
Wei Ma,Xiukun Wan,Ge Yao et al.
Wei Ma et al.
Pogostemon cablin (Blanco) Benth. cv. 'Jing Huoxiang', is a valuable medicinal plant widely studied for its aboveground tissues, which are rich in bioactive compounds such as patchouli alcohol. However, systematic investigations into the bi...