Adaptation of Non-Invasive Cancer Cells to 3D Collagen I Microenvironment Induces Transcriptional Reprogramming Accompanied by a More Complex RNA Landscape [0.03%]
非侵袭性癌细胞适应I型胶原蛋白三维微环境可诱导转录重编程并伴随复杂的RNA景观变化
Theresa Wießner-Kroh,Stefanie Hübschmann,Gudrun Marquardt et al.
Theresa Wießner-Kroh et al.
Nowadays, most cancer research still depends on traditional cell culture in Petri dishes or cell culture flasks which do not have the ability to mimic physiological-like conditions in vitro. However, the behavior of cancer cells strongly re...
Human Myeloid-Derived Growth Factor Induces a Pro-Angiogenic Response and Functional Recovery in a Mouse Model of Peripheral Artery Disease [0.03%]
人源粒细胞系来源的生长因子通过促进血管生成改善小鼠外周动脉疾病模型的功能恢复
Anton Pekcec,Maria Myzithras,Cornelia Walther et al.
Anton Pekcec et al.
Myeloid-derived growth factor (MYDGF) is a monocyte- and macrophage-secreted protein with anti-apoptotic and pro-angiogenic properties that has demonstrated protective effects in models of myocardial ischemia, but its role in peripheral isc...
Luiza Marek-Józefowicz,Alina Borkowska,Bogusław Nedoszytko et al.
Luiza Marek-Józefowicz et al.
The SARS-CoV-2 virus has infected approximately 778 million people worldwide since the pandemic. Patients who have survived coronavirus disease (COVID-19) may experience long-term symptoms related to cognitive deficits, mood changes, and de...
Adaptation of the Transcriptome and miRNAome in Response to Hepatocellular Hypoxia [0.03%]
肝细胞缺氧对转录组和microRNA的影响
Jenica H Kakadia,Cristiana Iosef,Ilka U Heinemann et al.
Jenica H Kakadia et al.
Inadequate supply of oxygen causing hypoxic cellular stress drives metabolic reprograming across diverse physiological conditions, including cancer. The activation of hypoxia-inducible factors (HIFs) to facilitate adaptation to low oxygen e...
Whole-Cell Transformation of Cannabidiol by Selected Filamentous Fungi into Novel Polar Derivatives [0.03%]
由选殖丝状真菌全细胞介导的四氢大麻酚向新型手性极性衍生物的转化
Daniel Łój,Tomasz Janeczko,Mariusz A Bromke et al.
Daniel Łój et al.
Cannabidiol (CBD) is a bioactive phytocannabinoid with considerable pharmacological potential. However, its limited aqueous solubility and high lipophilicity remain significant barriers to its broader pharmaceutical application. In this stu...
Antimicrobial Properties of Freeze-Dried Hyaluronic Acid Sheets Containing Persimmon Tannin [0.03%]
含柿单宁冻干透明质酸钠膜的抗菌性能
Yasuhisa Sawai,Miho Hasumoto,Takanobu Takata et al.
Yasuhisa Sawai et al.
Oral mucositis is a frequent adverse effect of cancer therapy and is often complicated by pain, oral dryness, and secondary infection. Freeze-dried hyaluronic acid (HA) sheets can protect and moisturize the oral mucosa, but their intrinsic ...
Systemic Neutralization of Granulocyte-Macrophage Colony-Stimulating Factor Attenuates Stellate Ganglion Neuroinflammation and Cardiac Sympathetic Overactivation in Chronic Heart Failure in Rats [0.03%]
大鼠慢性心力衰竭时系统中和粒细胞-巨噬细胞集落刺激因子抑制星状神经元炎症和心脏交感神经过度激活
Sulail Fatima,Lauren Whitney,Yu Li et al.
Sulail Fatima et al.
Chronic heart failure (CHF) is characterized by heightened cardiac sympathetic activity and neuroinflammation within the stellate ganglia (SG), contributing to cardiac arrhythmogenesis. However, the upstream mediators of this neuroimmune in...
Terpenoids as Emerging Senotherapeutics: Mechanistic Insights and Therapeutic Potential [0.03%]
作为新兴的细胞衰老疗法的萜类化合物：机制见解和治疗潜力
Sungwoo Yi,Jung Yoon Park,Sung-Joon Lee
Sungwoo Yi
Cellular senescence, characterized by stable cell cycle arrest, drives organismal aging and functional decline. Senescent cells (SnCs) increase in multiple tissues with age and contribute to pathology by resisting apoptosis, impairing regen...
Genome-Wide Dissection of the TCP Gene Family in Peach and Expression Analysis Under Drought Stress [0.03%]
基于桃基因组的TCP基因家族鉴定及干旱逆境表达分析
Yanfu Jing,Yang Yu,Zimin Xiao et al.
Yanfu Jing et al.
The TCP (Teosinte branched 1/Cycloidea/Proliferating) gene family comprises plant-specific transcription factors essential for regulating growth, development, and environmental adaptation. Utilizing the high-quality 'Rui Youpan 1' ('RYP1') ...
Genome-Wide Dissection of the TCP Gene Family in Peach and Expression Analysis Under Drought Stress [0.03%]
基于基因组的桃TCP家族基因鉴定及干旱逆境表达分析
Yanfu Jing,Yang Yu,Zimin Xiao et al.
Yanfu Jing et al.
The TCP (Teosinte branched 1/Cycloidea/Proliferating) gene family comprises plant-specific transcription factors essential for regulating growth, development, and environmental adaptation. Utilizing the high-quality 'Rui Youpan 1' ('RYP1') ...