Distinct Modulation of High- and Low-Frequency Activity by Midazolam and Neurosteroids in Neocortical Slices [0.03%]
咪达唑仑和神经营养素对新皮层切片高低频活动的差异化调节作用
Stefan Bieletzki,Clara Gotthard,Xènia Puig-Bosch et al.
Stefan Bieletzki et al.
Adverse effects of benzodiazepines are largely mediated by GABAA receptors containing α1-subunits. Recent efforts to replace benzodiazepines with neurosteroids are promising, but it is unclear to what extent α1-GABAA receptors are also up...
Assessment of Hypercoagulability After Orthopedic Trauma Surgery Using Coagulation Biomarkers and TEG/ROTEM [0.03%]
基于凝血生物标志物和TEG/ROTEM评估骨科手术后高凝状态
Bogdan Huzum,Dan Viorel Cionca,Daniel Ciupilan et al.
Bogdan Huzum et al.
Orthopedic trauma surgery is associated with an increased risk of postoperative hypercoagulability, predisposing patients to potentially life-threatening thromboembolic complications, including deep vein thrombosis (DVT) and pulmonary embol...
The Pan-Plastome of Walnuts (Juglans regia L.) from Xinjiang Reveals New Insights into Their Genetic Diversity [0.03%]
新疆核桃泛基因组研究揭示了核桃遗传多样性的新见解
Lulu Zhang,Fangdong Geng,Huijuan Zhou et al.
Lulu Zhang et al.
Persian walnut (Juglans regia L.) is an economically important tree species in the Juglandaceae family. Comparative analysis of its chloroplast genome sequences is of great significance for species identification and evolutionary research. ...
Droplet Digital PCR Assessment of MDM2 Amplification in Liposarcoma Diagnosis and Prognosis: A French Single-Center Cohort Study [0.03%]
法国单中心队列研究中评估DD-PCR测定MDM2扩增在脂肪肉瘤诊断和预后中的价值
Amira Amri,Aurélie Haffner,Fréderic Fina et al.
Amira Amri et al.
Amplification of MDM2 is the molecular hallmark of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) and dedifferentiated liposarcoma (DDL). While fluorescence in situ hybridization (FISH) is widely used for diagnosis, the...
Sirtuins as Molecular Mediators of Caloric Restriction in the Pancreas: Implications for β-Cell Function, Metabolism, and Longevity [0.03%]
丝裂酶作为胰腺卡里限制的分子介体：对β细胞功能、新陈代谢及长寿的影响
Katarzyna Zgutka,Wioletta Mikołajek-Bedner,Kamila Szumilas et al.
Katarzyna Zgutka et al.
Caloric restriction (CR), defined as a 30-60% decrease in ad libitum food intake without malnutrition, has emerged as one of the most robust non-pharmacological interventions for promoting metabolic health and longevity in various species, ...
Advances in miRNA-Mediated Bidirectional Crosstalk and Immune Evasion Mechanisms Between Lung Cancer Cells and CD8+ T Cells [0.03%]
microRNA介导的肺癌细胞与CD8+T细胞之间双向互作和免疫逃逸机制的研究进展
Xinyi Zhou,Tao Pang,Zhe Ge
Xinyi Zhou
Lung cancer ranks first in both incidence and mortality among all malignancies, and tumor microenvironment (TME)-induced CD8+ T cell exhaustion is a critical factor driving immune evasion and compromising the efficacy of immunotherapy. Micr...
Transcriptomic and Metabolomic Insights into Tissue- and Cultivar-Dependent Polysaccharide Accumulation in Anoectochilus roxburghii [0.03%]
石斛属 Roxburgh石斛组织和品系特异性多糖积累的转录组学和代谢组学研究见解
Xiaoqun Peng,Chao Liu,Yiping Liu et al.
Xiaoqun Peng et al.
Polysaccharides are major bioactive constituents and quality-related components of Anoectochilus roxburghii. However, how polysaccharide accumulation varies among cultivars and tissues remains poorly understood. Here, crude polysaccharide c...
Macrophage Plasticity in Cancer Therapy: Function, Timing, and Tradeoffs [0.03%]
癌症治疗中的巨噬细胞的多功能性、时机和权衡取舍
Olga Kovaleva,Alexei Gratchev
Olga Kovaleva
Tumor-associated macrophages (TAMs) are considered to be one of the most attractive targets in cancer therapy but attempts to target them have produced variable and often contradictory results. Their phenotype and function are shaped by dev...
Beyond DCFH-DA: A Critical Review of Hydrogen Peroxide and Superoxide Detection Strategies in Mammalian Living Systems (2015-2026) [0.03%]
超越DCFH-DA：哺乳动物活细胞中过氧化氢和超氧阴离子检测策略的批判性综述（2015-2026）
Luciana Alexandra Pavelescu,Antoanela Curici,Violeta Liuba Călin
Luciana Alexandra Pavelescu
Reactive oxygen species (ROS) regulate cellular signaling at physiological concentrations and drive tissue damage when their generation exceeds antioxidant defenses. The conceptual reframing of the field into oxidative eustress (low, contro...
Generation and Application of Ultra-Fine, Long-Term Stable Nanobubble Water: An Evaluation of Inclusion Effects on Aromatic Components and Antimicrobial Activity [0.03%]
超细长效纳微米气泡水的生成及应用：包覆对芳香成分及抗菌性能影响评估
Shin Shimizu,Mikiko Tanaka,Nanami Tominaga et al.
Shin Shimizu et al.
Nano- and pico-bubble water (NPB), containing hydrogen or ozone, is widely used as a cleaning agent due to its bactericidal and antiviral properties. However, some products-such as certain hydrogen waters-contain only large bubbles or have ...