Network Pharmacology and In Vivo Validation Reveal Berberine-Mediated Regulation of the Liver-Brain Inflammatory Axis in MCD-Induced Steatohepatitis [0.03%]
网络药理学及体内验证揭示小檗碱介导的肝性神经炎症轴在MCD诱导的 steatohepatitis 中的调节作用
Yeon-Joo Yoo,Ji-Han Kim,Seung-Hoon Yoo et al.
Yeon-Joo Yoo et al.
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive immunometabolic liver disorder involving lipid dysregulation, inflammation, fibrosis, and extrahepatic immune-neural responses, yet therapies capable of modulating the...
Prognostic Significance of B7-H3 Expression and CD163+ Tumor-Associated Macrophage Infiltration in Mesothelioma [0.03%]
B7-H3表达和CD163+肿瘤相关巨噬细胞在间皮瘤中的预后价值
Tülay Koç,Ramazan Oğuz Yüceer,Tuncay Altay et al.
Tülay Koç et al.
Mesothelioma is a rare, aggressive malignancy with poor prognosis. B7-H3 (CD276), an immune checkpoint molecule, and CD163-positive tumor-associated macrophages (TAMs) contribute to tumor progression and immune evasion. This study evaluated...
Auricular Vagus Nerve Stimulation in Inflammatory Bowel Disease: Mechanistic Insights and Biomarker-Based Evaluation of Therapeutic Response [0.03%]
耳部迷走神经刺激在炎症性肠病中的作用机制及基于生物标志物的疗效评估
Elif Zeynep Öztürk,Mehlika Alataş
Elif Zeynep Öztürk
Inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is a chronic inflammatory disorder characterized by dysregulated host-microbiota interactions, epithelial barrier dysfunction, and aberrant imm...
Advances in Aptamer Diagnostics Targeting Non-Small-Cell Lung Cancer: A Systematic Review [0.03%]
针对非小细胞肺癌的适配子诊断研究进展：系统性综述
Lisa Agnello,Ilaria Leone,Alessandra Affinito et al.
Lisa Agnello et al.
Non-small-cell lung cancer (NSCLC) is one of the most frequent cancer types and is responsible for the majority of cancer-related deaths worldwide. For this reason, initial diagnosis, prognosis, and targeted therapy of NSCLC represent very ...
Patient-Derived Organoids in Gastrointestinal Disease: Current Applications, Limitations, and Future Perspectives [0.03%]
基于患者衍生类器官的胃肠疾病研究：当前应用、局限性及未来前景
Amanda Caruso,Yasmine Hamrouni,Antonella Delvecchio et al.
Amanda Caruso et al.
The development of patient-derived organoids (PDOs) has substantially advanced the study of gastrointestinal diseases by providing three-dimensional human models that faithfully recapitulate the structural, molecular, and functional charact...
Patient-Derived Organoids in Gastrointestinal Disease: Current Applications, Limitations, and Future Perspectives [0.03%]
基于患者的类器官在胃肠疾病中的应用、局限性及未来前景
Amanda Caruso,Yasmine Hamrouni,Antonella Delvecchio et al.
Amanda Caruso et al.
The development of patient-derived organoids (PDOs) has substantially advanced the study of gastrointestinal diseases by providing three-dimensional human models that faithfully recapitulate the structural, molecular, and functional charact...
Grape-Derived Exosome-like Nanoparticles Ameliorate Prediabetes in Mice via Amino Acid Metabolic Reprogramming [0.03%]
葡萄衍生的类外泌体纳米颗粒通过氨基酸代谢重编程改善小鼠糖尿病前期
Zaoling Liu,Shuya Cai,Aerna Qiayimaerdan et al.
Zaoling Liu et al.
This study investigates the effects of grape-derived exosomes on prediabetic mice and elucidates their underlying mechanisms through an integrated metabolomics approach. A prediabetic mouse model was established, with 18 mice randomly assig...
Integrative Multivariate Genomics Identifies Shared Epithelial-Immune and Cytokine-Regulatory Mechanisms Across Major Chronic Lung Diseases [0.03%]
整合多组学识别主要慢性肺疾病中上皮免疫和细胞因子调节的共同机制
Chung-Chih Liao,Ke-Ru Liao,Jung-Miao Li
Chung-Chih Liao
Chronic lung diseases, including asthma, chronic obstructive pulmonary disease, bronchiectasis, and idiopathic pulmonary fibrosis, are clinically distinct but share epithelial injury, host-defense, inflammatory, and remodeling processes. We...
Beyond the Brain: GABAergic Signaling as a Peripheral Modulator of Skin Barrier Immunity [0.03%]
超越大脑：GABAergic信号作为皮肤屏障免疫的外周调节器
Ruoyu Wan,Wei Hua
Ruoyu Wan
Beyond its canonical role as the principal inhibitory neurotransmitter in the central nervous system (CNS), peripheral GABAergic signaling has emerged as an important regulator of skin barrier immunity and tissue homeostasis. This review sy...
Distinct Modulation of High- and Low-Frequency Activity by Midazolam and Neurosteroids in Neocortical Slices [0.03%]
咪达唑仑和神经甾体在新皮层切片中对高频和低频活动的调节作用不同
Stefan Bieletzki,Clara Gotthard,Xènia Puig-Bosch et al.
Stefan Bieletzki et al.
Adverse effects of benzodiazepines are largely mediated by GABAA receptors containing α1-subunits. Recent efforts to replace benzodiazepines with neurosteroids are promising, but it is unclear to what extent α1-GABAA receptors are also up...