Plant In Vitro Production of Phenolic Bioactives: Molecular Regulation, Functional Equivalence and Translational Challenges [0.03%]
植物体外酚类活性物质的生产：分子调控、功能等效性及转化挑战
Anna Kujawska,Paulina Król,Oleksandra Laban et al.
Anna Kujawska et al.
Phenolic compounds are important plant secondary metabolites with broad biological activity and potential applications in pharmaceutical, food, cosmetic, nutraceutical, and veterinary sectors. Conventional production from field-grown plants...
Failure to Fuse Shut Eyelids, a Novel Unique Sign in Affected Fetus with Homozygous PPP1R13L Pathogenic Variant-A Case Report and Review of the Literature [0.03%]
联合免疫缺陷病患者胎儿致死性同合PPP1R13L基因病理性变异的独特表型：一例报道及文献复习
Zaher Shalata,Hila Mintz,Sami Haddad et al.
Zaher Shalata et al.
Prompted by a fetus with a homozygous PPP1R13L pathogenic variant and persistent open eyelids on sonography, suggesting fusion failure, this study marks the first prenatal human description linking PPP1R13L to eyelid closure, mirroring wave...
Mesenchymal Stromal Cell-Based Therapies in Sepsis-Induced Acute Lung and Kidney Injury: Current Advances and Perspectives [0.03%]
间充质基质细胞在防治脓毒症肺肾损伤中的研究进展与展望
Carla M da Silva,Mayck M A da Silva,Marcelo M Morales
Carla M da Silva
Sepsis is a life-threatening syndrome characterized by severe immune dysregulation, frequently culminating in acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI). Current supportive therapies fail to reverse the underly...
A Generalizable and Interpretable Framework for Molecular Subtype Classification of Pancreatic Ductal Adenocarcinoma Integrating Conformal Uncertainty Quantification and Consensus-Based Explainable Artificial Intelligence Across Multiple Cohorts [0.03%]
一种泛化性和可解释性良好的胰腺导管腺癌分子亚型分类框架，整合了多种形式的不确定性量化和基于共识的可解释人工智能技术，适用于多个队列研究
Seyma Yasar,Fatma Hilal Yagin,Sarah A Alzakari et al.
Seyma Yasar et al.
Pancreatic ductal adenocarcinoma (PDAC) has two principal molecular subtypes-classical and basal-like-with divergent prognosis and chemotherapy response, yet transcriptomic classifiers rarely generalize across cohorts or quantify per-patien...
A Generalizable and Interpretable Framework for Molecular Subtype Classification of Pancreatic Ductal Adenocarcinoma Integrating Conformal Uncertainty Quantification and Consensus-Based Explainable Artificial Intelligence Across Multiple Cohorts [0.03%]
一种通用且可解释的框架：整合多个队列的符合一致性可解释人工智能的规范不确定性量化，用于胰腺导管腺癌分子亚型分类
Seyma Yasar,Fatma Hilal Yagin,Sarah A Alzakari et al.
Seyma Yasar et al.
Pancreatic ductal adenocarcinoma (PDAC) has two principal molecular subtypes-classical and basal-like-with divergent prognosis and chemotherapy response, yet transcriptomic classifiers rarely generalize across cohorts or quantify per-patien...
Endobronchial Intratumoral Immuno- and Gene Therapies in Lung Cancer: Mechanisms of Local Delivery, Systemic Immune Effects, and Global Feasibility [0.03%]
支气管内肿瘤免疫和基因治疗在肺癌中的机制、全身免疫效应及全球可行性研究
Mihai Olteanu,Gabriela Marina Andrei,Ramona Cioboată et al.
Mihai Olteanu et al.
Lung cancer remains the leading cause of cancer-related mortality worldwide, and durable benefit from immune checkpoint inhibitors is limited by immune exclusion, microenvironmental immunosuppression, and toxicity. This narrative translatio...
Time-Resolved Metabolomics Reveals Distinct, Cell- and Variety-Dependent Profiles of Prostanoids in Melanoma Cells Exposed to Fruit Extracts from Cornus mas and C. officinalis: A Pilot Study [0.03%]
基于时间代谢组学的果醋一清颗粒对黑色素瘤细胞花生四烯酸代谢产物的影响：一项初步研究
Łukasz Lewandowski,Małgorzata Krzystek-Korpacka,Daria Mykhailova et al.
Łukasz Lewandowski et al.
Chronic inflammation and cyclooxygenase (COX)-2-mediated prostanoid signaling contribute to melanoma progression, yet their modulation by natural products remains poorly defined. We examined the effects of dogwood fruit extracts-Japanese co...
COPS7B Drives Malignant Progression of Glioblastoma Through Translational Upregulation of the Downstream Functional Effector CLU [0.03%]
COPS7B通过CLU的翻译后上调驱动胶质母细胞瘤恶性进展
Jiarui Li,Meiling Zhang,Fan Xu et al.
Jiarui Li et al.
Glioblastoma (GBM) is a highly aggressive primary malignant brain tumor, featuring diffuse infiltrative growth and poor clinical outcomes, which underscores the need to delineate the molecular mechanisms driving its malignant progression. C...
The Role of Cytochrome P450 Holoenzyme Metabolism in the Origin of Neuropathologies [0.03%]
细胞色素P450全酶代谢在神经病理起源中的作用
Snježana Štambuk
Snježana Štambuk
The increased activity of δ-aminolevulinic acid synthase-1 (ALAS1) leads to the accumulation of δ-aminolevulinic acid (ALA), which may reduce the iron(III) retention ability of ferritin, resulting in iron(III) overload. The accumulation o...
Matrix Metalloproteinases and Cardiac Remodelling in Smokers with Acute Coronary Syndrome [0.03%]
吸烟急性冠脉综合征患者的基质金属蛋白酶与心脏重塑关系的研究
Amilia Aminuddin,Nazirah Samah,Faridah Mohd Nor et al.
Amilia Aminuddin et al.
Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) regulate extracellular matrix remodeling and contribute to the pathogenesis of coronary artery disease (CAD). This study examined the associations between MMP-2, MMP-9, an...