QSAR-Guided Virtual Screening and Molecular Dynamics Reveal Olaparib as a Repurposing Lead Against α-Synuclein Aggregation [0.03%]
基于QSAR的虚拟筛选及分子动力学模拟揭示Olaparib可作为抗α-突触核蛋白聚集的再定位先导药物
Mena Abdelsayed,Yassir Boulaamane
Mena Abdelsayed
Parkinson's disease (PD) is characterised by the pathological aggregation of α-synuclein (α-syn) into Lewy body inclusions, yet no disease-modifying therapy exists. To address this, we developed an integrated computational pipeline combin...
Broad-Spectrum Multi-Epitope Design Targeting Conserved Hantavirus Glycoproteins (Gn/Gc): Chimeric Antigen Engineering and Structural Mapping [0.03%]
针对汉坦病毒保守糖蛋白（GN/GC）的广谱多表位设计：嵌合抗原工程与结构定位映射
Silvia da Silva Fontes,Fernando Paiva Conte,Jorlan Fernandes et al.
Silvia da Silva Fontes et al.
Hantaviruses, the etiological agents of hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS), represent a high-risk zoonotic threat with substantial global health impact. Currently, there is no FDA-approved v...
Tracking Nano- and Microplastics in Plants: Uptake Pathways, Tissue Distribution, and Analytical Strategies from Microscopy to Spectroscopy [0.03%]
植物中纳米和微塑料的追踪：从显微镜到光谱学的吸收途径，组织分布和分析策略
Abdullah Maqsood,Ewa Łobos-Moysa,Amna Jameel et al.
Abdullah Maqsood et al.
Nano- and microplastics (NMPs) are now widely detected across agroecosystems and can act as physiological stressors in plants. Exposure occurs through contaminated soil, irrigation water, or airborne deposition, bringing particles into dire...
Evaluation of HER2 and Nectin-4 Expression in Primary Vaginal Cancers [0.03%]
原发性阴道癌中HER2和nectin-4的表达检测
Gilbert Georg Klamminger,Hanna Wattendorff,Felix Hässlin et al.
Gilbert Georg Klamminger et al.
This study assessed the prevalence and clinical relevance of p16INK4a, p53, HER2, and Nectin-4 protein expression in primary vaginal cancer (PVC), with HER2 and Nectin-4 representing potentially druggable targets. A total of 34 patients wit...
Proteasome-Enriched hPPSCs-Derived EVs Attenuate Hypoxic Injury in Endothelial Cells via Proteasome-Mediated HIF-1α Degradation [0.03%]
富蛋白酶体诱导的多能干细胞源性外泌体通过蛋白酶体介导缺氧诱导因子降解缓解内皮细胞缺氧损伤
Junyan Hao,Ying Wang,Youyu Ma et al.
Junyan Hao et al.
Stem cell-derived extracellular vesicles (EVs) hold therapeutic potential for hypoxia-associated injury, yet the molecular mechanisms underlying their protective effects remain incompletely defined. Herein, we performed comparative proteomi...
Integrated Breeding Approaches for Ascochyta Blight Resistance in Chickpea [0.03%]
整合育种方法在 chickpea抗叶枯病中的应用
Kadir Akan,Duygu Sari,Hatice Sari et al.
Kadir Akan et al.
Ascochyta blight (AB), caused by the necrotrophic fungus [Ascochyta rabiei (Pass.) Labr.], is one of the most destructive diseases of chickpea (Cicer arietinum L.), causing yield losses of up to 100% under favorable conditions. The pathogen...
Multi-Targeted Neuroprotection by Areca catechu Against Cisplatin-Induced Neurotoxicity: Cellular, Caenorhabditis elegans, and Metabolomic Evidence [0.03%]
betel坚果对顺铂诱导的神经毒性的多靶点神经保护作用：细胞、线虫和代谢组学证据
Kishore K Kumaree,Clerance Su Yee Cheong,Kanika Verma et al.
Kishore K Kumaree et al.
Cisplatin is an effective platinum-based chemotherapeutic agent used to treat a variety of cancers. However, its clinical utility is limited by dose-dependent neurotoxicity, yet no approved neuroprotective strategy currently exists. Our int...
Estrogen Withdrawal-Induced Cognitive Impairment in Menopausal Women: Mechanisms and Prospects for Integrated Interventions [0.03%]
绝经女性的雌激素缺乏所致认知损害：发病机制及综合干预策略展望
Tiantian Qiu,Junying Zhang,Jiayou Zhao
Tiantian Qiu
A marked reduction in estrogen levels during perimenopause substantially elevates the risk of Alzheimer's disease (AD) and cognitive dysfunction in women. While the endocrine etiology is well established, applying this understanding to effe...
ELAVL1-KO Affects Steroid Synthesis in ACC Cell Line NCI-H295R and Reduces Colony-Forming Abilities [0.03%]
ELAVL1基因敲除影响ACC细胞系NCI-H295R类固醇合成并降低克隆形成能力
Max Brandau,Vanessa Kirsch,Dmitry Chernyakov et al.
Max Brandau et al.
Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal gland for which no curative treatment options exist in advanced stages. Analyzing the ACC cohort of The Cancer Genome Atlas, we identified that expression of the mRNA-stabil...
Investigation of Cytokine Profiles, the Expression of Genes Involved in Somatic Hypermutation and Peripheral Tolerance, and Their Correlation with Autoantibody Levels in Northern-Thai Immunodeficient Patients Carrying Anti-Interferon-γ Autoantibodies [0.03%]
携带抗干扰素-γ自身抗体的泰国北部免疫缺陷患者细胞因子谱、体细胞高频突变及外周耐受相关基因表达及其与自身抗体水平相关性的研究
Kritsadee Rattanathammethee,Kriangkrai Chawansuntati,Nongkran Lumjuan et al.
Kritsadee Rattanathammethee et al.
Anti-interferon-γ (IFN-γ) autoantibody (AAb)-associated adult-onset immunodeficiency (AOID) is an emerging disorder in East Asian adults characterized by severe opportunistic infections despite negative HIV status. The mechanisms driving ...