Hepatic SIRT6 Deficiency Accelerates Female-Specific Aging Through SULT1E1-Mediated Estrogen Depletion [0.03%]
肝SIRT6缺陷通过SULT1E1介导的雌激素耗竭加速性别特异性衰老
Yonghui Liu,Ziliang Zhang,Tingting Wang et al.
Yonghui Liu et al.
Sexual dimorphism is a fundamental feature of aging, yet the liver-centric mechanisms underlying sex-specific aging trajectories remain incompletely understood. SIRT6, a NAD+-dependent deacetylase, is a master regulator of genome stability,...
Edible Fungal Polysaccharide-Liposome: Interfacial Interactions, Structure-Function Relationship, and Emerging Application in Oral Delivery and Functional Foods [0.03%]
可食用的真菌多糖-脂质体：界面相互作用、结构功能关系及其在口服递送和功能性食品中的新兴应用
Jiachen Liang,Abdul Mueed,Abdul Basit et al.
Jiachen Liang et al.
Liposomes are among the most extensively studied delivery systems owing to their biocompatibility, structural versatility, and ability to improve the stability and bioavailability of bioactive compounds. Meanwhile, edible fungal polysacchar...
Urine-Derived Stem Cells: Challenges in Isolation, Biological Identity, and Therapeutic Potential in CKD-Associated Fibrosis [0.03%]
尿源性干细胞在慢性肾病相关纤维化中的分离、生物学特性和治疗潜力的挑战
Queenesa Amabel Sunjaya,Ahmad Faried,Rudi Supriyadi et al.
Queenesa Amabel Sunjaya et al.
Urine-derived stem cells (UDSCs) have emerged as a promising cell source for regenerative medicine due to their non-invasive procurement, high proliferative capacity, and potential relevance to kidney-specific repair. Unlike conventional me...
Combined Omeprazole and Glycyrrhiza glabra L. Extract Attenuate Ethanol-Induced Gastric Ulceration Through Modulation of TLR4/NF-κB/NLRP3 Signaling and Upregulation of PI3K/AKT/mTOR Gene Expression [0.03%]
甘草提取物与奥美拉唑联用通过调节TLR4/NF-κB /NLRP3信号通路以及上调PI3K/AKT/mTOR基因表达来缓解酒精性胃溃疡
Sahar Khateeb,Mody Albalawi,Amnah Obidan et al.
Sahar Khateeb et al.
Ethanol (EtOH)-induced gastric ulcer (GU) is a common model used to investigate mechanisms of mucosal injury and repair. Omeprazole (OMP) is a conventional anti-ulcer drug that effectively suppresses gastric acid secretion, but its efficacy...
Combined Omeprazole and Glycyrrhiza glabra L. Extract Attenuate Ethanol-Induced Gastric Ulceration Through Modulation of TLR4/NF-κB/NLRP3 Signaling and Upregulation of PI3K/AKT/mTOR Gene Expression [0.03%]
甘草提取物联合奥美拉唑通过调节TLR4/NF-κB/NLRP3信号通路及上调PI3K/AKT/mTOR基因表达缓解酒精性胃黏膜损伤
Sahar Khateeb,Mody Albalawi,Amnah Obidan et al.
Sahar Khateeb et al.
Ethanol (EtOH)-induced gastric ulcer (GU) is a common model used to investigate mechanisms of mucosal injury and repair. Omeprazole (OMP) is a conventional anti-ulcer drug that effectively suppresses gastric acid secretion, but its efficacy...
Computationally Generated Plant-Derived Berberine-Based Hybrid Compounds as Potential Dual Binders to Staphylococcus aureus FtsZ/FabI Enzymes: A Ligand-Based Approach [0.03%]
基于计算的植物小分子金丝桃素衍生物杂化化合物作为潜在的双结合配体靶向耐甲氧西林金黄色葡萄球菌FtsZ/FabI酶：基于配体的方法
Julio César Robles-Romero,Jael Quintero-Vargas,Karen Ochoa Lara et al.
Julio César Robles-Romero et al.
Staphylococcus aureus (S. aureus) remains a major global pathogen and a significant public health concern due to its antibiotic resistance. This has spurred the search for new treatments, resulting in the discovery of two promising targets:...
Molecular Biomarkers of Radiosensitivity and Radioresistance in Cervical Cancer: A Systematic Review [0.03%]
宫颈癌放射敏感性和放射抵抗性的分子生物标志物的系统评价
Anamaria Hermina Girbovan,Cristina Balan,Alexandra Timea Kirsch-Mangu et al.
Anamaria Hermina Girbovan et al.
The primary aim of this review is to summarize current evidence from clinical and pre-clinical studies on endogenous molecular biomarkers associated with radiosensitivity and radioresistance in cervical cancer, including patients treated wi...
Proteomic Characterization of Replication Stress and Impaired Antioxidant Defense in Tacrolimus-Induced Chronic Nephrotoxicity [0.03%]
环孢素诱导的慢性肾毒性的复制压力和抗氧化防御受损的蛋白质组特征分析
Tamaki Ishima,Sho Nishida,Shota Tomida et al.
Tamaki Ishima et al.
Tacrolimus (TAC) nephropathy is a major complication of immunosuppressive therapy and contributes to chronic kidney disease (CKD) progression through ischemia, metabolic dysfunction, and oxidative stress; however, its protein-level basis re...
The Possible Association Between Bisphenol A (BPA) and the Neuropathological Processes Characteristic of Alzheimer's Disease-A Systematic Review of the Literature [0.03%]
双酚A(BPA)与阿尔茨海默病的神经病理过程可能存在的关联——文献综述
Marta Żebrowska-Gamdzyk,Mateusz Maciejczyk
Marta Żebrowska-Gamdzyk
Bisphenol A (BPA) is a ubiquitous environmental endocrine-disrupting compound whose potential neurotoxicity is attracting increasing interest. A growing body of evidence suggests a possible link between BPA exposure and neurodegenerative pr...
QSAR-Guided Virtual Screening and Molecular Dynamics Reveal Olaparib as a Repurposing Lead Against α-Synuclein Aggregation [0.03%]
基于QSAR的虚拟筛选及分子动力学模拟揭示Olaparib可作为抗α-突触核蛋白聚集的再定位候选药物
Mena Abdelsayed,Yassir Boulaamane
Mena Abdelsayed
Parkinson's disease (PD) is characterised by the pathological aggregation of α-synuclein (α-syn) into Lewy body inclusions, yet no disease-modifying therapy exists. To address this, we developed an integrated computational pipeline combin...