Festa Margherita,Pianta Marta,Miskovsky Pavel et al.
Festa Margherita et al.
Dielectric permittivity describes how a material becomes polarized in response to a time-varying electric field and provides a powerful framework for probing the physical organization of biological systems. This review aims to clarify the o...
Effects of Nano-Hydroxyapatite-Coated PRF on Gingiva-Derived Mesenchymal Stem Cells: In Vitro Study [0.03%]
纳米羟基磷灰石包被的富生长因子血浆对牙龈间充质干细胞影响的体外研究
İzzet Melih Gürkan,Bahar Demir Cevizlidere,Seçil Çalişkan et al.
İzzet Melih Gürkan et al.
Platelet-rich fibrin (PRF) has been widely used in regenerative dentistry because of its potential to support tissue regeneration. Recently, modifications in PRF preparation protocols and tube surface characteristics have attracted attentio...
Xanomeline-Trospium Validates Muscarinic Agonism as an Effective Non-Dopaminergic Treatment for Schizophrenia [0.03%]
新型药物Xanomeline-Trospium临床试验揭示毒蕈碱激动剂可有效治疗非多巴胺能精神分裂症
Ghaith K Mansour,Ahmad W Hajjar,Adnan H Hajjar et al.
Ghaith K Mansour et al.
Schizophrenia remains a debilitating global health challenge where pharmacologic treatment has been stagnant for over seventy years, relying almost exclusively on the blockade of dopamine receptors. While this mechanism controls positive ps...
Temporal Vulnerability of the Blood-Brain Interface in Stroke: Molecular Mechanisms of Circadian Dynamics, Inflammation, and Aging [0.03%]
脑卒中时空易感性：昼夜节律、炎症和衰老的分子机制
Sarah Asif,Jennifer W Mitchell,Martha U Gillette
Sarah Asif
Stroke remains one of the leading causes of long-term disability and death worldwide. Growing evidence suggests that both stroke onset and severity exhibit strong circadian patterns. This blood-brain interface (BBI), which regulates bidirec...
High-Glucose-Induced Metabolic and Epithelial Stress in Grass Carp Intestinal Epithelial Cells Associated with Methylation-Related Transcriptional Responses [0.03%]
高血糖引起的草鱼肠上皮细胞代谢和上皮应力与甲基化相关的转录反应有关
Linjie Qian,Wenqiang Jiang,Yan Lin et al.
Linjie Qian et al.
High-glucose exposure impairs intestinal metabolic homeostasis and barrier integrity in fish, but the transcriptional responses associated with high-glucose adaptation in fish intestinal epithelial cells remain incompletely understood. This...
Analysis of the Efficacy of Acetylcholinesterase Inhibitors in the Treatment of Alzheimer's Disease, Literature Review [0.03%]
胆碱酯酶抑制剂治疗阿尔茨海默病有效性的 meta 分析及文献回顾
Wiktor Petrov,Dawid Ślebioda,Rozalia Kozińska et al.
Wiktor Petrov et al.
The term 'dementia' encompasses a diverse group of progressive neurodegenerative disorders, the common feature of which is the deterioration of higher cortical functions. This process not only involves memory deficits and language communica...
Risk Factors and Predictive Biomarkers for Postoperative Complications in Crohn's Disease Surgery: Systematic Review [0.03%]
克罗恩病手术后并发症的风险因素和预测生物标志物：系统综述
Bobuțac Eduard,Zaharie Delia Roxana,Vălean Dan et al.
Bobuțac Eduard et al.
Surgical intervention in Crohn's disease remains a significant contributor to patient morbidity, with postoperative complication rates reported between 20% and 50%. These complications include a broad spectrum of adverse outcomes, such as s...
Proteasome Dysfunction and Aggregation-Prone Proteins in Neurodegenerative Diseases: From Mechanisms to Therapeutic Opportunities [0.03%]
蛋白酶体功能障碍和易聚集蛋白在神经退行性疾病中的作用：从机制到治疗机会
Youngwon Kim,Yong-Keun Jung
Youngwon Kim
Neurodegenerative diseases are characterized by the accumulation of misfolded and aggregation-prone proteins, reflecting a failure of proteostasis. The ubiquitin-proteasome system (UPS), a major pathway for selective intracellular protein d...
Lipid-Induced Endothelial Dysfunction: Pro-Atherogenic Properties of Multinucleated Variant Endothelial Cells [0.03%]
脂质诱导的内皮功能障碍：具有促动脉粥样硬化特性的多核变异内皮细胞
Vadim Cherednichenko,Diana Kiseleva,Ulyana Khovantseva et al.
Vadim Cherednichenko et al.
Endothelial dysfunction is an early event in the development of cardiovascular diseases and is characterized by impaired barrier function, inflammatory activation of endothelial cells (ECs), and alterations in lipid metabolism. In addition ...
Retrieval-Based Evaluation of Cell Painting Feature Spaces Reveals Differences in the Preservation of Biologically Meaningful Phenotypic Similarity [0.03%]
基于检索的评估揭示了细胞绘画特征空间中生物意义表型相似性的保存差异
Xenia Kuznetsova,Larisa Kuznetsova,Elina Shabunina et al.
Xenia Kuznetsova et al.
Cell Painting enables high-dimensional phenotypic profiling of cellular states, but retrieval-based interpretation depends on whether the chosen feature space preserves task-relevant biological relationships. With pretrained Cell Painting f...