Proteome-Level Autophagy-Lysosome Remodelling Marks Ageing in Human Dermal Fibroblasts and Nominates Hydroxytyrosol as a Candidate Nutraceutical [0.03%]
人真皮成纤维细胞蛋白质组水平的自噬溶酶体重塑可作为衰老标志并提名水解酪醇为候选保健品
Meng Cai,Meihong Xu
Meng Cai
Autophagy-lysosome dysfunction accompanies dermal fibroblast ageing, yet whether remodelling is transcriptional or post-transcriptional in primary human cells remains unresolved. We reanalysed the Genetic and Epigenetic Signatures of Transl...
Proteome-Level Autophagy-Lysosome Remodelling Marks Ageing in Human Dermal Fibroblasts and Nominates Hydroxytyrosol as a Candidate Nutraceutical [0.03%]
人真皮纤维细胞蛋白质组水平的自噬溶酶体重塑标志着衰老并提名水解酪酚为候选营养保健品
Meng Cai,Meihong Xu
Meng Cai
Autophagy-lysosome dysfunction accompanies dermal fibroblast ageing, yet whether remodelling is transcriptional or post-transcriptional in primary human cells remains unresolved. We reanalysed the Genetic and Epigenetic Signatures of Transl...
Matricellular Proteins in Bladder Cancer: Context-Dependent Roles in Tumor Promotion and Suppression [0.03%]
基质细胞蛋白在膀胱癌中的作用：肿瘤促进和抑制的上下文依赖性角色
Azamat Akhmetkaliyev,José Héctor Gibrán Fritz García,Eva Sonnenberg-Riethmacher et al.
Azamat Akhmetkaliyev et al.
Bladder cancer (BLCA) is a common and heterogeneous malignancy in which disease progression is driven not only by tumor-intrinsic alterations but also by dynamic interactions within the tumor microenvironment (TME). Increasing evidence posi...
Neurovascular Involvement in Arterial Tortuosity Syndrome Associated with a Homozygous SLC2A10 p.(Trp162Ter) Variant: Clinical, Molecular, and In Silico Characterization [0.03%]
与SLC2A10纯合变异体同源相关动脉纡曲综合征的神经血管受累：临床、分子和计算机表征
Serdar Bozlak,Cuneyd Yavas,Evrim Yalcin et al.
Serdar Bozlak et al.
Arterial Tortuosity Syndrome (ATS) is a rare autosomal recessive connective tissue disorder caused by pathogenic variants in SLC2A10, which encodes the facilitative glucose transporter GLUT10. Although its vascular features are well recogni...
Integrating Biosynthetic, Genomic and Ecological Open Data for Medicinal Plant Research: A Leakage-Aware Evidence-Prioritization Framework [0.03%]
基于生态学、基因组和生物合成的公开数据用于药用植物研究的渗漏感知证据优先框架
Lidiia S Samarina,Nina V Terletskaya,Yury L Orlov
Lidiia S Samarina
Medicinal plant research increasingly combines heterogeneous public data, but data leakage and unsupported biological inference remain major risks. We developed a leakage-aware framework separating taxon-compound evidence ranking from envir...
Influence of Light Quality During Spreading on the Chemical and Aromatic Profile of Summer Green Tea [0.03%]
光照质量对夏季绿茶摊放过程中化学和香气成分的影响
Xiaojiao Xia,Ling Lin,Fan Xu et al.
Xiaojiao Xia et al.
The use of different light qualities during the spreading stage can influence the flavor of green tea. In this study, freshly harvested leaves were exposed to red (GRL), yellow (GYL), blue (GBL), or natural light (GCK, as the control) throu...
Extracellular Vesicles as Mediators of Pathophysiology and Disease Progression in Cardiovascular Diseases [0.03%]
心血管疾病病理生理和疾病进展的细胞外囊泡介导机制
Melina Tangos,Luca Schneider,Oliver Jarkas et al.
Melina Tangos et al.
The rising prevalence of cardiovascular diseases (CVDs) worldwide imposes a substantial economic burden on healthcare systems. Despite major advances in evidence-based therapies and modern healthcare, the demand for novel, time- and cost-ef...
Effects of Collagen Peptides Derived from Perch Scale Hydrolysates on the Physiological Activity of Osteoblasts [0.03%]
源自鲈鱼鳞低聚肽对成骨细胞生理活性的影响
Chih-Ping Hsu,Hsiang Chang,Ling-Ni Chen et al.
Chih-Ping Hsu et al.
A plethora of studies have demonstrated the bioactive properties of collagen peptides, including the promotion of wound healing and bone health. Research has demonstrated that these effects are attributable to their elevated biocompatibilit...
Effects of Collagen Peptides Derived from Perch Scale Hydrolysates on the Physiological Activity of Osteoblasts [0.03%]
鲈鱼鳞肽对成骨细胞生理活性的影响
Chih-Ping Hsu,Hsiang Chang,Ling-Ni Chen et al.
Chih-Ping Hsu et al.
A plethora of studies have demonstrated the bioactive properties of collagen peptides, including the promotion of wound healing and bone health. Research has demonstrated that these effects are attributable to their elevated biocompatibilit...
Research Progress on Astaxanthin Plus Exercise for the Prevention and Treatment of Knee Osteoarthritis: A Traditional Narrative Review [0.03%]
虾青素联合运动预防和治疗膝骨关节炎的研究进展：传统综述性评论文章
Rui Cheng,Wei Wu,Xiaomei Zu
Rui Cheng
Knee osteoarthritis (KOA) is a degenerative joint disease characterized by inflammatory reactions and bone lesions within the joint, which is mainly caused by the degeneration of articular cartilage. This disease primarily affects middle-ag...