ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function [0.03%]
ATP8B1和ATP11C：两种重要的肝细胞脂质翻转酶
Jyoti Naik,Dirk R de Waart,Karina Utsunomiya et al.
Jyoti Naik et al.
P4 ATPases are lipid flippases and transport phospholipids from the exoplasmic to the cytosolic leaflet of biological membranes. Lipid flipping is important for the biogenesis of transport vesicles. Recently it was shown that loss of the P4...
Diet1 is a regulator of fibroblast growth factor 15/19-dependent bile acid synthesis [0.03%]
饮食1是成纤维细胞生长因子15/19依赖性胆汁酸生物合成的调节剂
Karen Reue,Jessica M Lee,Laurent Vergnes
Karen Reue
Background: A fascinating aspect of bile acid homeostasis is the coordination between bile acid uptake in intestine and hepatic bile acid synthesis. In response to bile acid uptake in enterocytes, farnesoid X receptor is ...
Shadi Abu-Hayyeh,Catherine Williamson
Shadi Abu-Hayyeh
Sulfated progesterone metabolites rise 100-fold in the third trimester of human pregnancy and have been shown to be elevated further in the gestational disorder intrahepatic cholestasis of pregnancy (ICP). Typical concentrations of progeste...
Dieter Häussinger
Dieter Häussinger
Vaccination and other antigen-specific immunomodulatory strategies in celiac disease [0.03%]
儿童乳糜泻的疫苗和其他抗原特异性免疫调节策略
Mauro Rossi
Mauro Rossi
Background: Celiac disease (CD) results from an alteration in the oral tolerance to dietary gluten. The response to gluten is normally tightly regulated and involves the secretion of TGF-β and IL-10 from different subtyp...
Katri Kaukinen,Katri Lindfors
Katri Kaukinen
Currently, the only effective treatment for celiac disease is a strict lifelong gluten-free diet. However, gluten-free dieting is restrictive, difficult to maintain and nutritionally less than optimal. The improved knowledge on celiac disea...
Peter R Gibson,Jane G Muir,Evan D Newnham
Peter R Gibson
Background: While it is well documented and widely appreciated that ingestion of wheat (and less so rye and barley) is associated with gastrointestinal symptoms such as bloating or abdominal pain, the component of wheat t...
Marios Hadjivassiliou,David D Sanders,Daniel P Aeschlimann
Marios Hadjivassiliou
The term gluten-related disorders (GRD) refers to a spectrum of diverse clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals. They include both intestinal and extraintestinal manifestations. Gl...
Wheat amylase trypsin inhibitors as nutritional activators of innate immunity [0.03%]
wheat amylase trypsin inhibitors可作为营养免疫激活剂发挥作用
Detlef Schuppan,Victor Zevallos
Detlef Schuppan
While the central role of an adaptive, T cell-mediated immune response to certain gluten peptides in celiac disease is well established, the innate immune response to wheat proteins remains less well defined. We identified wheat amylase try...
Stijn J B Van Weyenberg,Chris J J Mulder,Jan Hein T M Van Waesberghe
Stijn J B Van Weyenberg
Background: Modern small bowel imaging techniques allow detailed depiction of small-intestinal abnormalities. The role of these techniques in the investigation of celiac disease is increasing, especially in patients with ...