Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases [0.03%]
饮食、胆汁酸代谢、肠道菌群和炎症性肠病之间的相互作用
Suzanne Devkota,Eugene B Chang
Suzanne Devkota
The composite human gut microbiomes of Western populations have changed over the past century, brought on by new environmental triggers that often have a negative impact on human health. Diets high in saturated fats and refined sugars and l...
Relationship between Obesity, Gut Microbiome and Hepatocellular Carcinoma Development [0.03%]
肥胖、肠道微生物群与肝细胞癌发生的关系
Eiji Hara
Eiji Hara
During the past several decades, the percentage of excess bodyweight and obese adults and children has increased dramatically, and is becoming one of the most serious public health problems worldwide. Extensive epidemiological studies have ...
Gut microbiota, cirrhosis, and alcohol regulate bile acid metabolism in the gut [0.03%]
肠道微生物群、肝硬化和酒精调节肠道内胆汁酸代谢
Jason M Ridlon,Dae-Joong Kang,Phillip B Hylemon et al.
Jason M Ridlon et al.
The understanding of the complex role of the bile acid-gut microbiome axis in health and disease processes is evolving rapidly. Our focus revolves around the interaction of the gut microbiota with liver diseases, especially cirrhosis. The b...
Bile acids and stellate cells [0.03%]
胆酸与星形细胞
Claus Kordes,Iris Sawitza,Silke Götze et al.
Claus Kordes et al.
Hepatic stellate cells are mainly known for their contribution to fibrogenesis in chronic liver diseases, but their identity and function in normal liver remain unclear. They were recently identified as liver-resident mesenchymal stem cells...
Steven A Kliewer,David J Mangelsdorf
Steven A Kliewer
While it has long been recognized that bile acids are essential for solubilizing lipophilic nutrients in the small intestine, the discovery in 1999 that bile acids serve as ligands for the nuclear receptor farnesoid X receptor (FXR) opened ...
Valeska Jourdainne,Noémie Péan,Isabelle Doignon et al.
Valeska Jourdainne et al.
Background: Most of the literature on the bile acid (BA) membrane receptor TGR5 is dedicated to its potential role in the metabolic syndrome, through its regulatory impact on energy expenditure, insulin and GLP-1 secretio...
ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function [0.03%]
ATP8B1和ATP11C：两种重要的肝细胞脂质翻转酶
Jyoti Naik,Dirk R de Waart,Karina Utsunomiya et al.
Jyoti Naik et al.
P4 ATPases are lipid flippases and transport phospholipids from the exoplasmic to the cytosolic leaflet of biological membranes. Lipid flipping is important for the biogenesis of transport vesicles. Recently it was shown that loss of the P4...
Diet1 is a regulator of fibroblast growth factor 15/19-dependent bile acid synthesis [0.03%]
饮食1是成纤维细胞生长因子15/19依赖性胆汁酸生物合成的调节剂
Karen Reue,Jessica M Lee,Laurent Vergnes
Karen Reue
Background: A fascinating aspect of bile acid homeostasis is the coordination between bile acid uptake in intestine and hepatic bile acid synthesis. In response to bile acid uptake in enterocytes, farnesoid X receptor is ...
Shadi Abu-Hayyeh,Catherine Williamson
Shadi Abu-Hayyeh
Sulfated progesterone metabolites rise 100-fold in the third trimester of human pregnancy and have been shown to be elevated further in the gestational disorder intrahepatic cholestasis of pregnancy (ICP). Typical concentrations of progeste...
Dieter Häussinger
Dieter Häussinger