Antje Caelers,Vesna Radojevic,Jens Traenkle et al.
Antje Caelers et al.
Studies conducted over the last few years demonstrated that signaling pathways that operate in the organs of Corti (OC) play a central role in survival and death of hair cells. An important goal of molecular otology is to characterize these...
Influence of cochlear function on auditory temporal resolution in tinnitus patients [0.03%]
耳蜗功能对耳鸣患者听觉时间分辨力的影响
Seisse Gabriela Gandolfi Sanches,Tanit Ganz Sanchez,Renata Mota Mamede Carvallo
Seisse Gabriela Gandolfi Sanches
Our aim was to analyze the influence of subtle cochlear damage on temporal auditory resolution in tinnitus patients. Forty-eight subjects (hearing threshold
Differentiating malingering balance disorder patients from healthy controls, compensated unilateral vestibular loss, and whiplash patients using stance and gait posturography [0.03%]
运用步态和姿态动态诊断装病性平衡功能障碍患者、健康人以及椎基底动脉供血不足与挥鞭伤患者
Jaap Vonk,Corinne G C Horlings,John H J Allum
Jaap Vonk
Differentiating balance disorder patients who are malingering from those with organic balance disorders is difficult and costly. We used trunk sway measured during several stance and gait tasks in 18 patients suspected of malingering in ord...
Relationship between the degree of endolymphatic hydrops and electrocochleography [0.03%]
膜迷路积水程度与电测听的关系研究
Masako Yamamoto,Masaaki Teranishi,Shinji Naganawa et al.
Masako Yamamoto et al.
The purpose of this study was to evaluate the relationship between the endolymphatic space image obtained using magnetic resonance imaging (MRI) and the results of electrocochleography. Electrocochleography recordings were obtained from 25 ...
Blocking the glucocorticoid receptor with RU-486 does not prevent glucocorticoid control of autoimmune mouse hearing loss [0.03%]
用RU-486阻断糖皮质激素受体不能阻止糖皮质激素控制自身免疫性小鼠听力损失
Dennis R Trune,J Beth Kempton
Dennis R Trune
Background/aims: Glucocorticoids effectively manage autoimmune hearing loss, although the cochlear mechanisms involved are unknown. Previous studies of steroid-responsive hearing loss in autoimmune (lupus) mice showed glu...
William F Sewell,Jeffrey T Borenstein,Zhiqiang Chen et al.
William F Sewell et al.
Background: Direct delivery of drugs and other agents into the inner ear will be important for many emerging therapies, including the treatment of degenerative disorders and guiding regeneration. ...
Sangeeta Maini,Halina Lisnichuk,Hayden Eastwood et al.
Sangeeta Maini et al.
Background: There is experimental evidence that targeted delivery of steroids to the inner ear can protect hearing during cochlear implant surgery. The best protection appears to be achieved through pre-treatment of the c...
Dose-dependent sustained release of dexamethasone in inner ear cochlear fluids using a novel local delivery approach [0.03%]
一种新型局部递送方法控制地塞米松在内耳耳蜗液体中按需缓释的浓度研究
Xiaobo Wang,Luis Dellamary,Rayne Fernandez et al.
Xiaobo Wang et al.
The thermo-reversible triblock copolymer poloxamer 407 was investigated as a drug delivery vehicle for micronized dexamethasone into the middle and inner ears of guinea pigs. The study characterized the gelation and in vitro release kinetic...
Christine T Dinh,Thomas R Van De Water
Christine T Dinh
The programmed cell death of stress-damaged auditory hair cells can occur through a variety of signal pathways, and therapeutic modalities that block pro-cell-death pathways are being developed and evaluated for hearing preservation. Becaus...
Amanda Hu,Lorne S Parnes
Amanda Hu
Background/aim: The use of intratympanic steroids (ITS) has proliferated over the past 10-15 years to include treatments for inner ear disorders, like Ménière's Disease (MD) and sudden sensorineural hearing loss (SSNHL)...