Hypoglycemia in sulfonylurea-treated KCNJ11-neonatal diabetes: Mild-moderate symptomatic episodes occur infrequently but none involving unconsciousness or seizures [0.03%]
磺酰脲类药物治疗的KCNJ11新生儿糖尿病患者的低血糖：轻至中度症状性低血糖发作较少但无导致意识丧失或癫痫发作者
Monica S Lanning,David Carmody,Łukasz Szczerbiński et al.
Monica S Lanning et al.
Background: Neonatal diabetes mellitus (NDM) caused by mutations in KCNJ11 can be successfully treated with high dose oral sulfonylureas; however, little data is available on the risk of hypoglycemia. ...
The proportion of familial cases of type 1 diabetes is increasing simultaneously with the disease incidence: Eighteen years of the Israeli Pediatric Diabetes Registry [0.03%]
以色列儿童糖尿病登记处18年数据显示：1型糖尿病发病与家族病史呈同步上升趋势
Amnon Zung,Wasef Na&#x;amnih,Yulia Bluednikov et al.
Amnon Zung et al.
Background: The global rise in incidence of type 1 diabetes (T1D) is too rapid to be attributed to susceptible genetic background, pinpointing a significant role for environmental factors. Unlike the theory that the need ...
FOXP3 mutations causing early-onset insulin-requiring diabetes but without other features of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome [0.03%]
导致需胰岛素治疗的儿童糖尿病但没有免疫失调综合征及其他特征的FOXP3基因突变
Jessica L Hwang,Soo-Young Park,Honggang Ye et al.
Jessica L Hwang et al.
Diabetes occurs in 1/90 000 to 1/160 000 births and when diagnosed under 6 months of age is very likely to have a primary genetic cause. FOXP3 encodes a transcription factor critical for T regulatory cell function and mutations are known to...
Case Reports
Pediatric diabetes. 2018 May;19(3):388-392. DOI:10.1111/pedi.12612 2018
Dorothy Becker,Richard Insel
Dorothy Becker
Impaired fasting glucose and the metabolic profile in Danish children and adolescents with normal weight, overweight, or obesity [0.03%]
空腹血糖受损与丹麦正常体重、超重或肥胖儿童和青少年的代谢特征的关系
Julie T Kloppenborg,Cilius E Fonvig,Tenna R H Nielsen et al.
Julie T Kloppenborg et al.
Objective: Whether the definitions of impaired fasting glucose (IFG) from the American Diabetes Association (ADA) and the World Health Organization (WHO) differentially impact estimates of the metabolic profile and IFG-re...
Low-grade inflammation and muscular fitness on insulin resistance in adolescents: Results from LabMed Physical Activity Study [0.03%]
青春期低度炎症和肌肉体能对胰岛素抵抗的影响：LabMed运动研究结果
César A Agostinis-Sobrinho,Robinson Ramírez-Vélez,Antonio García-Hermoso et al.
César A Agostinis-Sobrinho et al.
Background: Low muscular fitness (MF) and low-grade inflammation has been linked to insulin resistance (IR). Objective: To evaluate the...
Multicenter Study
Pediatric diabetes. 2018 May;19(3):429-435. DOI:10.1111/pedi.12607 2018
Safety and efficacy of autoantigen-specific therapy with 2 doses of alum-formulated glutamate decarboxylase in children with multiple islet autoantibodies and risk for type 1 diabetes: A randomized clinical trial [0.03%]
谷氨酸脱羧酶铝佐剂疫苗对多发胰岛自身抗体阳性儿童预防1型糖尿病的疗效和安全性：一项随机临床试验
Helena Elding Larsson,Markus Lundgren,Berglind Jonsdottir et al.
Helena Elding Larsson et al.
Objective: Treatments have failed to delay or stop the autoimmune process, preceding onset of type 1 diabetes. We investigated if autoantigen-specific treatment with alum-formulated glutamate decarboxylase (GAD-Alum) was ...
Randomized Controlled Trial
Pediatric diabetes. 2018 May;19(3):410-419. DOI:10.1111/pedi.12611 2018
Randomized, double-blind, placebo-controlled dose-finding study of the dipeptidyl peptidase-4 inhibitor linagliptin in pediatric patients with type 2 diabetes [0.03%]
Linagliptin（拉尼agliptin），一种二肽基肽酶-4抑制剂在青少年2型糖尿病患者中的剂量探索性的随机双盲安慰剂对照研究
William V Tamborlane,Lori Mb Laffel,Jacques Weill et al.
William V Tamborlane et al.
Objective: To identify the dose of the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin in pediatric patients with type 2 diabetes (T2D). Methods: ...
Clinical Trial
Pediatric diabetes. 2018 Jun;19(4):640-648. DOI:10.1111/pedi.12616 2018
Feasibility and pilot study of an intervention to support active lifestyles in youth with type 1 diabetes: The ActivPals study [0.03%]
一项支持1型糖尿病青年积极生活方式的干预措施的研究及其可行性研究：ActivPals 研究
Fiona Mitchell,Louise Wilkie,Kenneth Robertson et al.
Fiona Mitchell et al.
Background: Evidence suggests youth with type 1 diabetes (T1D) have lower levels of physical activity (PA) than the general population. The ActivPals intervention aimed to support youth with T1D to lead an active lifestyl...
Randomized Controlled Trial
Pediatric diabetes. 2018 May;19(3):443-449. DOI:10.1111/pedi.12615 2018
Cardiovascular autonomic dysfunction predicts increasing albumin excretion in type 1 diabetes [0.03%]
心血管自主神经功能紊乱预示1型糖尿病患者尿白蛋白排泄量的增加
Liangjian Lu,M Loredana Marcovecchio,R Neil Dalton et al.
Liangjian Lu et al.
Objective: To determine the potential role of cardiovascular autonomic dysfunction in the development of renal complications in young people with type 1 diabetes (T1D). ...