Insulin resistance is associated with smaller brain volumes in a preliminary study of depressed and obese children [0.03%]
一项初步研究：胰岛素抵抗与抑郁和肥胖儿童较小的脑容量有关
Owen R Phillips,Alexander K Onopa,Yevgeniya V Zaiko et al.
Owen R Phillips et al.
Objective: During childhood, the brain can consume up to 65% of total calories, and a steady supply of the brain's main fuel glucose needs to be maintained. Although the brain itself is not dependent on insulin for the up...
Immune cell and cytokine patterns in children with type 1 diabetes mellitus undergoing a remission phase: A longitudinal study [0.03%]
纵向研究1型糖尿病患儿缓解期的免疫细胞和细胞因子模式
Ana Laura Fitas,Catarina Martins,Luís Miguel Borrego et al.
Ana Laura Fitas et al.
Objective: Type 1 diabetes (T1D) develops in distinct stages, before and after disease onset. Whether the natural course translates into different immunologic patterns is still uncertain. This study aimed at identifying p...
Sex-related association of serum uric acid with inflammation, kidney function and blood pressure in type 1 diabetic patients [0.03%]
1型糖尿病患者血尿酸的性别差异及其与炎症、肾功能和血压的关系
Bartosz Słomiński,Maria Skrzypkowska,Monika Ryba-Stanisławowska et al.
Bartosz Słomiński et al.
Background/objective: Recent studies suggest that uric acid (UA) is a mediator of diabetic nephropathy. We hypothesized that serum UA would associate with the prevalence of diabetic nephropathy in youth with type 1 diabet...
The influence of food order on postprandial glucose levels in children with type 1 diabetes [0.03%]
1型糖尿病儿童中食物摄入顺序对餐后血糖水平的影响
Elise M Faber,Paulien M van Kampen,Agnes Clement-de Boers et al.
Elise M Faber et al.
Objective: To evaluate the effect of the order of intake of carbohydrates, protein, and fat on postprandial glucose levels in children with type 1 diabetes (T1D). Our hypothesis was that postprandial glucose levels would ...
Randomized Controlled Trial
Pediatric diabetes. 2018 Jun;19(4):809-815. DOI:10.1111/pedi.12640 2018
Permanent neonatal diabetes mellitus and neurological abnormalities due to a novel homozygous missense mutation in NEUROD1 [0.03%]
NEUROD1新杂合错义突变导致的永久性新生儿糖尿病和神经异常
Huseyin Demirbilek,Nihal Hatipoglu,Ulku Gul et al.
Huseyin Demirbilek et al.
The basic helix-loop-helix (bHLH) transcription factor, neuronal differentiation 1 (NEUROD1) (also known as BETA2) is involved in the development of neural elements and endocrine pancreas. Less than 10 reports of adult-onset non-insulin-dep...
Case Reports
Pediatric diabetes. 2018 Aug;19(5):898-904. DOI:10.1111/pedi.12669 2018
A phase 3 multicenter, open-label, prospective study designed to evaluate the effectiveness and ease of use of nasal glucagon in the treatment of moderate and severe hypoglycemia in children and adolescents with type 1 diabetes in the home or school setting [0.03%]
评估在家庭和学校环境中使用鼻用胰高血糖素治疗1型糖尿病儿童和青少年中度低血糖和重度低血糖的有效性和便利性的3期多中心、开放标签、前瞻性研究
Larry C Deeb,Hélène Dulude,Cristina B Guzman et al.
Larry C Deeb et al.
Objective: This multicenter, open-label study was designed to evaluate real-world effectiveness and ease of use of nasal glucagon (NG) in treating moderate or severe hypoglycemic events in children and adolescents with ty...
Clinical Trial
Pediatric diabetes. 2018 Aug;19(5):1007-1013. DOI:10.1111/pedi.12668 2018
Young children with type 1 diabetes can achieve glycemic targets without hypoglycemia: Results of a novel intensive diabetes management program [0.03%]
年轻的1型糖尿病儿童可以达到血糖目标值而不发生低血糖：一种新型的强化糖尿病治疗项目的成果
Helen Phelan,Bruce King,Donald Anderson et al.
Helen Phelan et al.
Background: Young children with type 1 diabetes (T1D) present unique challenges for intensive diabetes management. We describe an intensive diabetes program adapted for young children and compare glycemic control, anthrop...
Advancing diabetes management in adolescents: Comparative effectiveness of mobile self-monitoring blood glucose technology and family-centered goal setting [0.03%]
青少年糖尿病管理的提升：移动血糖自我监测技术与以家庭为中心的目标设定的比较效果研究
Tamara S Hannon,Lisa G Yazel-Smith,Amy S Hatton et al.
Tamara S Hannon et al.
Background: As adolescents gain autonomy, it remains important for parents to be involved with diabetes management to avoid deterioration in glycemic control. Technologies for self-monitoring of blood glucose (SMBG) allow...
Randomized Controlled Trial
Pediatric diabetes. 2018 Jun;19(4):776-781. DOI:10.1111/pedi.12648 2018
"KiDS and Diabetes in Schools" project: Experience with an international educational intervention among parents and school professionals [0.03%]
“KiDS和学校中的糖尿病”项目：针对家长和学校专业人士的国际教育干预措施经验总结
Glaucia Margonari Bechara,Fernanda Castelo Branco,Avelino Luiz Rodrigues et al.
Glaucia Margonari Bechara et al.
Background: Although it is known that school care is a major challenge in diabetes treatment, there is still no published international initiative. Object...
Clinical Trial
Pediatric diabetes. 2018 Jun;19(4):756-760. DOI:10.1111/pedi.12647 2018
A phase I study of anti-inflammatory therapy with rilonacept in adolescents and adults with type 1 diabetes mellitus [0.03%]
关于在1型糖尿病患者中使用riloniccept进行抗炎治疗的I期临床研究
Perrin C White,Soumya Adhikari,Ellen K Grishman et al.
Perrin C White et al.
Background: The innate immune system may be activated around the time of diagnosis of type 1 diabetes (T1D). Components of this system, including cytokines such as interleukin-1β (IL-1β) represent potential therapeutic ...
Clinical Trial
Pediatric diabetes. 2018 Jun;19(4):788-793. DOI:10.1111/pedi.12634 2018