The Reproducibility and Reliability of Insulin Sensitivity and Secretion Indices in Children and Adolescents [0.03%]
儿童和青少年胰岛素敏感性和分泌指标的可重复性和可靠性研究
Nellie Said Hani,Mary Ellen Vajravelu,Jennifer L Meijer et al.
Nellie Said Hani et al.
Context: Insulin sensitivity and secretion indices can be useful tools in understanding insulin homeostasis in children at risk for diabetes. There have been few studies examining the reproducibility of these measures in ...
Observational Study
Pediatric diabetes. 2024:2024:2136173. DOI:10.1155/2024/2136173 2024
High Rate of Islets Autoimmunity in Pediatric Patients with Index Admission of Acute Pancreatitis [0.03%]
急性胰腺炎儿童患者中较高的自身免疫性标题：高危等自身免疫发生率
Jonathan D Tatum,Lindsey Hornung,Melena D Bellin et al.
Jonathan D Tatum et al.
Introduction: The underlying pathophysiology of diabetes mellitus after acute pancreatitis is unknown and overall risk of developing diabetes postacute pancreatitis in children is understudied. The objective of our study ...
High Prevalence of A-β+ Ketosis-Prone Diabetes in Children with Type 2 Diabetes and Diabetic Ketoacidosis at Diagnosis: Evidence from the Rare and Atypical Diabetes Network (RADIANT) [0.03%]
儿童2型糖尿病和诊断时糖尿病酮症酸中毒中A-β阳性酮体倾向性糖尿病的高流行率：来自罕见和非典型糖尿病网络（RADIANT）的证据
Elizabeth Kubota-Mishra,Xiaofan Huang,Charles G Minard et al.
Elizabeth Kubota-Mishra et al.
Background: A-β+ ketosis-prone diabetes (KPD) in adults is characterized by presentation with diabetic ketoacidosis (DKA), negative islet autoantibodies, and preserved β-cell function in persons with a phenotype of obes...
Household Food Insecurity and Cognition in Youth and Young Adults with Youth-Onset Diabetes [0.03%]
儿童及青年人糖尿病患者的家庭食物不安全与认知功能之间的关系
Andrea D Brown,Angela D Liese,Allison L B Shapiro et al.
Andrea D Brown et al.
Objective: We evaluated the association of household food insecurity (FI) with cognition in youth and young adults with type 1 diabetes (T1D) or type 2 diabetes (T2D). ...
DNA Methylation Near DLGAP2 May Mediate the Relationship between Family History of Type 1 Diabetes and Type 1 Diabetes Risk [0.03%]
DLGAP2附近的DNA甲基化可能介导1型糖尿病家族史和1型糖尿病风险之间的关系
Randi K Johnson,Amanda J Ireton,Patrick M Carry et al.
Randi K Johnson et al.
Given the differential risk of type 1 diabetes (T1D) in offspring of affected fathers versus affected mothers and our observation that T1D cases have differential DNA methylation near the imprinted DLGAP2 gene compared to controls, we exami...
Diabetes complications and cognitive function in young adults with youth-onset type 1 or type 2 diabetes: the SEARCH for Diabetes in Youth Study [0.03%]
青年期发病1型和2型糖尿病患者的糖尿病并发症与成年早期认知功能损害：SEARCH糖尿病青少年病例研究
Allison L B Shapiro,Anna Bellatorre,Dana Dabelea et al.
Allison L B Shapiro et al.
Aims/hypotheses: People with type 1 (T1D) or type 2 diabetes (T2D) who also have diabetes complications can have pronounced cognitive deficits. It remains unknown, however, whether and how multiple diabetes complications ...
Can HbA1c Alone Be Safely Used to Guide Insulin Therapy in African Youth with Type 1 Diabetes? [0.03%]
HbA1c单独用于指导非洲1型糖尿病青年胰岛素治疗是否安全？
Thereza Piloya-Were,Lucy W Mungai,Antoinette Moran et al.
Thereza Piloya-Were et al.
Introduction: The relationship of HbA1c versus the mean blood glucose (MBG) is an important guide for diabetes management but may differ between ethnic groups. In Africa, the patient's glucose information is limited or un...
Clinical Characterization of Data-Driven Diabetes Clusters of Pediatric Type 2 Diabetes [0.03%]
基于数据驱动的儿童2型糖尿病临床特征分类研究
Mahsan Abbasi,Mustafa Tosur,Marcela Astudillo et al.
Mahsan Abbasi et al.
Background: Pediatric Type 2 diabetes (T2D) is highly heterogeneous. Previous reports on adult-onset diabetes demonstrated the existence of diabetes clusters. Therefore, we set out to identify unique diabetes subgroups wi...
Initial Insights into the Genetic Variation Associated with Metformin Treatment Failure in Youth with Type 2 Diabetes [0.03%]
二甲双胍治疗失败的2型糖尿病青少年遗传变异初步研究
Shylaja Srinivasan,Ling Chen,Miriam Udler et al.
Shylaja Srinivasan et al.
Metformin is the first-line treatment for type 2 diabetes (T2D) in youth but with limited sustained glycemic response. To identify common variants associated with metformin response, we used a genome-wide approach in 506 youth from the Trea...
Increased Use of Hyperosmolar Therapy for Suspected Clinically Apparent Brain Injury in Pediatric Patients with Diabetic Ketoacidosis during the Peak of the COVID-19 Pandemic [0.03%]
2019冠状病毒病疫情高峰期间疑似颅内损伤患儿糖尿病酮症酸中毒高渗治疗的应用增多
Svetlana Azova,Enju Liu,Joseph Wolfsdorf
Svetlana Azova
The incidence of pediatric diabetic ketoacidosis (DKA) increased during the peak of the COVID-19 pandemic. The objective of this study was to investigate whether rates of hyperosmolar therapy administration for suspected clinically apparent...