Synthesis, characterization, and cytotoxicity in human erythrocytes of multifunctional, magnetic, and luminescent nanocrystalline rare earth fluorides [0.03%]
多功能磁性和发光稀土氟化物纳米晶体的合成、表征及对人红细胞的细胞毒性作用研究
Tomasz Grzyb,Lucyna Mrówczyńska,Agata Szczeszak et al.
Tomasz Grzyb et al.
Multifunctional nanoparticles exhibiting red or green luminescence properties and magnetism were synthesized and thoroughly analyzed. The hydrothermal method was used for the synthesis of Eu3+- or Tb3+-doped GdF3-, NaGdF4-, and BaGdF5-based...
Perspectives on the design of safer nanomaterials and manufacturing processes [0.03%]
关于更安全纳米材料及制造过程设计的思考
Charles Geraci,Donna Heidel,Christie Sayes et al.
Charles Geraci et al.
A concerted effort is being made to insert Prevention through Design principles into discussions of sustainability, occupational safety and health, and green chemistry related to nanotechnology. Prevention through Design is a set of princip...
Nadine Voigt,Petra Henrich-Noack,Sarah Kockentiedt et al.
Nadine Voigt et al.
Polybutylcyanoacrylate nanoparticles (PBCA NPs) are candidates for a drug delivery system, which can cross the blood-brain barrier (BBB). Because little is known about their toxicity, we exposed cells to PBCA NPs in vitro and in vivo and mo...
Evaluation of the efficiency of tumor and tissue delivery of carrier-mediated agents (CMA) and small molecule (SM) agents in mice using a novel pharmacokinetic (PK) metric: relative distribution index over time (RDI-OT) [0.03%]
一种新型药代动力学指标：一段时间内的相对分布指数(RDI-OT)，用于评价小分子和载体介导药物在荷瘤小鼠体内传递效率的方法论研究论文
Andrew J Madden,Sumit Rawal,Katie Sandison et al.
Andrew J Madden et al.
The pharmacokinetics (PK) of carrier-mediated agents (CMA) is dependent upon the carrier system. As a result, CMA PK differs greatly from the PK of small molecule (SM) drugs. Advantages of CMAs over SMs include prolonged circulation time in...
"Real-world" precision, bias, and between-laboratory variation for surface area measurement of a titanium dioxide nanomaterial in powder form [0.03%]
粉末状二氧化钛纳米材料表面积测量的实验精度、偏差和实验室间的差异性
Vincent A Hackley,Aleksandr B Stefaniak
Vincent A Hackley
Accurate characterization of nanomaterial properties is a critical component of any nanotoxicology testing strategy. Data that describes the performance of various laboratories in measuring the characteristics of the same nanomaterial are s...
Comparative analysis of the labelling of nanotechnologies across four stakeholder groups [0.03%]
四大利益相关者群体间纳米技术标签标示的比较分析
Adam Capon,James Gillespie,Margaret Rolfe et al.
Adam Capon et al.
Societies are constantly challenged to develop policies around the introduction of new technologies, which by their very nature contain great uncertainty. This uncertainty gives prominence to varying viewpoints which are value laden and hav...
Integrated probabilistic risk assessment for nanoparticles: the case of nanosilica in food [0.03%]
食品用纳米二氧化硅的综合概率风险评估案例研究
Rianne Jacobs,Hilko van der Voet,Cajo J F Ter Braak
Rianne Jacobs
Insight into risks of nanotechnology and the use of nanoparticles is an essential condition for the social acceptance and safe use of nanotechnology. One of the problems with which the risk assessment of nanoparticles is faced is the lack o...
Comparative hazard analysis and toxicological modeling of diverse nanomaterials using the embryonic zebrafish (EZ) metric of toxicity [0.03%]
使用胚胎斑马鱼(EZ)毒性评价指标进行不同纳米材料的比较危害分析和毒理学建模研究
Bryan Harper,Dennis Thomas,Satish Chikkagoudar et al.
Bryan Harper et al.
The integration of rapid assays, large datasets, informatics, and modeling can overcome current barriers in understanding nanomaterial structure-toxicity relationships by providing a weight-of-the-evidence mechanism to generate hazard ranki...
Pulmonary toxicity of well-dispersed titanium dioxide nanoparticles following intratracheal instillation [0.03%]
经气管内灌注后良好分散的二氧化钛纳米粒子的肺毒性研究
Yukiko Yoshiura,Hiroto Izumi,Takako Oyabu et al.
Yukiko Yoshiura et al.
In order to investigate the pulmonary toxicity of titanium dioxide (TiO2) nanoparticles, we performed an intratracheal instillation study with rats of well-dispersed TiO2 nanoparticles and examined the pulmonary inflammation and histopathol...
Bioavailability and biodistribution of differently charged polystyrene nanoparticles upon oral exposure in rats [0.03%]
口服暴露于大鼠体内不同电荷的聚苯乙烯纳米颗粒的生物利用度和生物分布
Agata P Walczak,Peter J M Hendriksen,Ruud A Woutersen et al.
Agata P Walczak et al.
The likelihood of oral exposure to nanoparticles (NPs) is increasing, and it is necessary to evaluate the oral bioavailability of NPs. In vitro approaches could help reducing animal studies, but validation against in vivo studies is essenti...