Biodegradable lipid nanoparticles for genome editing in the brain via intrathecal administration [0.03%]
通过腰椎给药用于大脑基因编辑的可降解脂质纳米颗粒
Songtao Dong,Lauren Healy,Fanglin Gong et al.
Songtao Dong et al.
Messenger RNA (mRNA)-based nonviral delivery of gene editors offers transformative potential for therapeutic genome editing in neurological diseases, but efficient and safe delivery to the brain remains a formidable challenge due to the res...
Engineering bone tissue with mRNA: from molecular design and delivery to clinical applications [0.03%]
基于mRNA的骨组织工程分子设计及临床应用
Claudia Del Toro Runzer,Martijn van Griensven,Elizabeth Rosado Balmayor
Claudia Del Toro Runzer
Bone possesses an intrinsic ability to regenerate after injury, but this capacity is often compromised in pathological conditions. Non-healing fractures are typically treated with autografts, which involve additional surgeries, patient disc...
Pei-Hsun Wu,Sanjiv Sam Gambhir,Christopher M Hale et al.
Pei-Hsun Wu et al.
Cumulative evidence shows that microenvironmental conditions play a significant role in the regulation of cell functions, and how cells respond to these conditions are of central importance to regenerative medicine and cancer cell response ...
Imidazolium Lipid-based Nanoparticles Enable Effective mRNA Delivery and Cellular Immune Response [0.03%]
咪唑类脂质纳米颗粒实现有效mRNA递送和细胞免疫反应
Jinghan Lin,Yining Zhu,Leonardo Cheng et al.
Jinghan Lin et al.
Imidazolium LipidBrick® cationic lipid nanoparticles (LNPs) provide a pH-independent alternative to conventional ionizable systems for nucleic acid delivery. Through a high-throughput screen of 1,944 formulations spanning eight imidazolium...
Biofabrication of engineered tissues by 3D bioprinting of tissue specific high cell-density bioinks [0.03%]
基于三维生物打印的组织特异性高细胞密度生物墨水的工程化组织生物制造
Oju Jeon,Hyoeun Park,J Kent Leach et al.
Oju Jeon et al.
Bioprinting of high cell-density bioinks is a promising technique for cellular condensation-based tissue engineering and regeneration medicine. However, it is still difficult to create precisely controlled complex structures and organizatio...
Alex Inman,Bita Soltan Mohammadlou,Kateryna Shevchuk et al.
Alex Inman et al.
As the Internet of Things (IoT) expands, electronics will take on new form factors. With the ubiquity of textiles in our daily lives, integrating functionality into them is a promising proposition. Realizing a future with textile-based elec...
Next-generation health monitoring: The role of nanomaterials in 3D-printed wearable devices [0.03%]
下一代健康监测：纳米材料在3D打印可穿戴设备中的作用
Chuchu Chen,Yonghao Fu,Yun Liu et al.
Chuchu Chen et al.
Wearable devices have made transformative advancements driven by the integration of nanomaterials, enhancing their versatility, sensitivity, and overall performance. The emerging 3D printing techniques revolutionize traditional fabrication,...
New block copolymers to form nanofibers with superior mechanical properties and to conjugate signaling molecules directing tissue regeneration [0.03%]
用于形成具有优异机械性能纳纤丝并连接指导组织再生信号分子的新型嵌段共聚物
Tongqing Zhou,Rafael C Cavalcante,Peter X Ma
Tongqing Zhou
Tissue engineering is a multidisciplinary field grown rapidly over the past few decades, whose success most often requires bioactive scaffolds to structurally support and biologically direct cell fate and tissue regeneration. Poly(l-lactic ...
Connie Wen,Yixun Wang,Yong Wang
Connie Wen
Aptamers, often described as "chemical antibodies", are short, single-stranded nucleic acids that can bind target molecules with high affinity and specificity. Due to these properties, aptamers have diverse therapeutic applications. They ca...
Aminophosphonate-Derived Lipid Nanoparticles Enable Circular RNA Delivery for Functional Recovery after Spinal Cord Injury [0.03%]
基于氨基膦酸的脂质纳米颗粒实现环形RNA递送促进脊髓损伤后的功能恢复
Haoyuan Li,Yuebao Zhang,Yichen Zhong et al.
Haoyuan Li et al.
Spinal cord injury (SCI) is a devastating neurological disorder that results in severe disability and imposes a high social and economic burden. Effective recovery from SCI requires comprehensive neural repair strategies, including neurogen...