Host Factors DDB2 and DNA Polymerase Delta Are Linked to cccDNA Persistence in Hepatitis B Virus and Occult Hepatitis B Virus-Related Hepatocellular Carcinoma [0.03%]
宿主因素DDB2和DNA聚合酶delta与乙型肝炎病毒和 occult 乙肝病毒相关肝细胞癌cccDNA持续存在有关
Kanyakorn Singsung,Athaya Vorasittha,Pisit Tangkijvanich et al.
Kanyakorn Singsung et al.
Covalently closed circular DNA (cccDNA), a stable episomal form of the hepatitis B virus (HBV) genome, functions as the transcriptional template for viral replication and persistence, posing a major barrier to HBV cure. While host DNA repai...
Low-Barrier Fibrosis Screening in Hepatitis C Treatment: The Decompensated Cirrhosis in Hepatitis C Evaluation Questionnaire [0.03%]
低门坎丙肝治疗肝纤维化筛查：丙型肝炎失代偿期肝硬化的评估问卷
Hunter Spencer,Barbara Brumbach,Anna Geduldig et al.
Hunter Spencer et al.
Achieving hepatitis C virus (HCV) elimination requires innovative paradigms that overcome barriers to treatment, such as requiring pre-treatment elastography or phlebotomy-based fibrosis assessment. To identify patients at low risk of advan...
A Framework for Emergency Department-Integrated Hepatitis C Test-and-Treat in the United States [0.03%]
美国集成急诊室乙型肝炎检测和治疗框架
Saeed S Graham
Saeed S Graham
Despite the availability of curative, direct-acting antiviral therapy, hepatitis C virus elimination remains incomplete. Losses across the care cascade continue to limit impact, from initial diagnosis to sustained virologic response. Fewer ...
Cost-Effectiveness of Interventions to Improve Retention in Care for Chronic Hepatitis B in the United States [0.03%]
美国慢性乙肝患者医疗费用效果研究
Irene Starinieri,Amit Chitnis,Robert J Wong et al.
Irene Starinieri et al.
Monitoring and retention in care remain suboptimal for patients diagnosed with chronic hepatitis B (CHB) infection with only a minority receiving consistent follow-up. This study evaluates the cost-effectiveness of interventions aimed at im...
Cost-Effectiveness of De Novo Combination of Tenofovir Alafenamide Fumarate and Peginterferon Alfa-2b Versus Peginterferon Alfa-2b Monotherapy of HBeAg-Positive Chronic Hepatitis B in China [0.03%]
富马酸特诺福韦艾拉酚胺与聚乙二醇干扰素α-2b联合治疗HBsAg阳性慢性乙肝患者的成本效果分析：在中国的模型研究
Na Wei,Maobai Liu,Hongfu Cai et al.
Na Wei et al.
Chronic hepatitis B (CHB) refers to a global infectious disease caused by the hepatitis B virus. The treatment of CHB causes a heavy economic burden to society. To ensure the rational allocation of medical resources in the whole society and...
Meta-Analysis of Genetic Variants Associated With HBV Infection Susceptibility and Hepatocellular Carcinoma Risk [0.03%]
与HBV感染易感性和肝细胞癌风险相关的遗传变异的meta分析研究
So Yoon Lee,Hyoung Doo Shin
So Yoon Lee
Hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) are serious medical problems worldwide. Today, many researchers believe that genetic variations play a major role in how easily someone gets infected and how the disease progresses ...
Meta-Analysis
Journal of viral hepatitis. 2026 May;33(5):e70175. DOI:10.1111/jvh.70175 2026
Utilizing Telemedicine to Engage Rural Patients With Substance Use Disorders in Low Barrier Hepatitis C Treatment [0.03%]
利用远程医疗使农村地区的物质使用障碍患者参与低门槛的丙肝治疗
Kristi C Hill,Sherilyn Brinkley,Maria Latimer et al.
Kristi C Hill et al.
Despite overall decline in hepatitis C virus (HCV) incidence in the United States, incidence in rural areas has continued to increase, primarily driven by injection drug use. Models of HCV care serving people in rural areas are needed. The ...
Exploration of a Model for Elimination of Hepatitis C in Women of Childbearing Age in Primary Hospitals in Southern China [0.03%]
我国南方地区综合性医院探索消除育龄期女性丙肝感染的模式研究
Li Guo,Wenbin Wu,Wen Zhou et al.
Li Guo et al.
Hepatitis C virus (HCV) can be transmitted from mother to child, although data on HCV elimination in women of childbearing age remain limited. This study aimed to evaluate an intervention model aligning with the 'treatment as prevention' st...
Characteristics of Patients and Factors Associated With the Development of Hepatitis C Virus-Associated Hepatocellular Carcinoma in an Urban, Primary-Care Based Hepatitis C Clinic [0.03%]
城市肝炎C门诊患者的特征及 hepatocellular carcinoma发生的相关因素
Kathryn Thompson,James Thompson,Lesley S Miller
Kathryn Thompson
Chronic hepatitis C virus infection (HCV) is one of the leading causes of hepatocellular carcinoma (HCC) in the United States. Using a retrospective cross-sectional analysis, this study identified patient characteristics and factors associa...