Single-Cell Transcriptome Identifies a Proinflammatory B-Cell Subset in Hepatitis B Virus Associated Acute-on-Chronic Liver Failure [0.03%]
单细胞转录组学识别与乙型肝炎病毒急性加重的慢性肝衰竭相关的促炎性B细胞亚群
Han Wang,Chuanshen Xu,Ruoyu Yao et al.
Han Wang et al.
Acute-on-chronic liver failure (ACLF) is a severe clinical condition with high short-term mortality, in part due to the dysfunctional immune response. Identifying immune mechanism under ACLF is critical to understand its pathogenesis and to...
Vertical Transmission in Mothers Taking TAF With Exceptionally High Viral Load [0.03%]
高病毒载量的母亲服用TAF的垂直传播研究
Huaibin Zou,Liying Zhu,Lihua Cao et al.
Huaibin Zou et al.
Published studies on tenofovir alafenamide (TAF) therapy for preventing vertical transmission of hepatitis B virus (HBV) have primarily enrolled mothers with viremic levels of approximately 7 log10 IU/mL. This study aimed to evaluate the ef...
Multicenter Study
Journal of viral hepatitis. 2025 Mar;32(3):e70000. DOI:10.1111/jvh.70000 2025
Perceived HBV-Related Stigma Is Associated With Lower Antiviral Medication Adherence in Patients With Chronic Hepatitis B [0.03%]
慢性乙型肝炎患者中，感知的HBV相关耻辱与较低的抗病毒药物依从性有关
Hee-Soon Juon,Daniel Yang,Cindy Xin Fang et al.
Hee-Soon Juon et al.
Medication nonadherence among patients with chronic hepatitis B (CHB) can lead to severe liver disease progression, including liver cirrhosis and hepatocellular carcinoma (HCC). Yet the factors that influence adherence in high-risk groups, ...
Liver Enzyme Elevation After Hepatitis C Virus Cure: Is There a Sex Effect? (ANRS CO13 HEPAVIH Cohort) [0.03%]
丙型肝炎治愈后肝脏酶升高与性别有关吗？(ANRS CO13 HEPAVIH队列研究)
Tangui Barré,Clémence Ramier,Karine Ory et al.
Tangui Barré et al.
Long-Term Outcome of Chronic Hepatitis B-Histological Score and Viral Genotype Are Important Predictors of Hepatocellular Carcinoma [0.03%]
慢性乙肝的长期结局：病理学评分和病毒基因型是预测肝细胞癌的重要因素
Anders Eilard,Johan Ringlander,Maria E Andersson et al.
Anders Eilard et al.
Current guidelines to prevent hepatocellular carcinoma (HCC) by chronic hepatitis B virus (HBV) infection are based on risk assessments that include age, sex, and virological and biochemical parameters. The study aim was to investigate the ...
Baseline Alpha-Fetoprotein Elevation and the Risk of Hepatocellular Carcinoma in Chronic Hepatitis B: A Multicentre Cohort Study [0.03%]
慢性乙型肝炎患者基线甲胎蛋白升高与肝细胞癌风险的关联：多中心队列研究
ChulHyoung Park,Gyubeom Hwang,Won-Mook Choi et al.
ChulHyoung Park et al.
Alpha-fetoprotein (AFP) level and its changes in chronic hepatitis B (CHB) may influence the risk of future hepatocellular carcinoma (HCC). This study aims to evaluate the HCC risk in CHB patients with no overt HCC but with elevated AFP lev...
Multicenter Study
Journal of viral hepatitis. 2025 Mar;32(3):e70006. DOI:10.1111/jvh.70006 2025
Long-Term Effects of Direct-Acting Antivirals on Hepatitis C: Trends in Liver Disease-Related Hospitalisations in Italy [0.03%]
直接抗病毒药对丙型肝炎的长期影响：意大利肝脏疾病相关住院率的变化趋势
Francesco Saverio Mennini,Paolo Sciattella,Claudia Simonelli et al.
Francesco Saverio Mennini et al.
This study aimed to evaluate the effectiveness of direct-acting antivirals (DAAs) on hepatitis C virus (HCV) hospitalisation trends in Italy, the country with not only the highest burden of HCV-related disease but also the highest number of...
Association of MASLD Phenotypes With Liver Fibrosis in Hepatitis C: The Role of Cardiometabolic Risk Factors [0.03%]
代谢性肝病与慢性丙型肝炎患者肝脏纤维化表型的相关性：心血管代谢危险因素的作用
Wesal Elgretli,Mohamed Shengir,Solomon Sasson et al.
Wesal Elgretli et al.
Steatotic liver disease is prevalent among people with hepatitis C virus (HCV). The new definition of metabolic dysfunction-associated steatotic liver disease (MASLD) emphasises the metabolic drivers of steatosis and recognises its frequent...
Xiaoqing Tan,Linting Xun,Qi Yin et al.
Xiaoqing Tan et al.
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Hepatitis B virus (HBV) is the main pathogen for HCC development. HBV covalently closed circular DNA (cccDNA) forms extra-host chromatin-like minichromosomes in the nuc...
Severe Liver-Related Outcomes in Patients With Hepatitis Delta: Results From a Multi-Ethnic Multicenter Long-Term Follow-Up Study [0.03%]
一项多族裔、多中心长期随访研究显示，乙型肝炎病毒合并感染丁型肝炎病毒可导致严重肝脏相关结局
Arno Furquim d&#x;Almeida,Erwin Ho,Liesbeth Govaerts et al.
Arno Furquim d&#x;Almeida et al.
Hepatitis B virus (HBV)-hepatitis delta virus (HDV) coinfection is the most severe form of chronic viral hepatitis, but the factors that determine disease progression and severity are incompletely characterised. This long-term follow-up stu...
Multicenter Study
Journal of viral hepatitis. 2025 Feb;32(2):1-15. DOI:10.1111/jvh.14060 2025