Persistent and emerging cancer risks after migration: Evidence from North and South Korean cohorts [0.03%]
移民后的持久和新兴癌症风险：来自朝鲜半岛南北队列的证据
Junshik Hong,Kyeong Jin Kim,Jimi Choi et al.
Junshik Hong et al.
Background: North Korean defectors in South Korea offer a rare natural model to trace cancer risk evolution after rapid environmental transition, given shared genetics but markedly contrasting early life exposures with So...
Who can safely discontinue lifelong follow-up among patients with sporadic pheochromocytoma and paraganglioma? [0.03%]
哪些散发型嗜铬细胞瘤和副神经节瘤患者可以安全地停止终生随访？
Min Jeong Park,Seung Shin Park,Won Woong Kim et al.
Min Jeong Park et al.
Background: Current guidelines recommend at least 10 years of follow-up for all pheochromocytoma and paraganglioma (PPGL) patients and lifelong monitoring for high-risk individuals. Nonetheless, data identifying patients ...
Increased intervals in enzyme replacement therapy for stable type 1 Gaucher disease: A non-inferiority sequential trial emulation [0.03%]
稳定型1型戈谢病患者中延长酶替代治疗间隔时间的非劣效性序贯试验模拟研究
Maxime Beydon,Jérôme Stirnemann,Karima Yousfi et al.
Maxime Beydon et al.
Objective: To compare the efficacy and safety of extended interval (Q3-4W) enzyme replacement therapy (ERT) versus standard biweekly (Q2W) ERT in clinically stable type 1 Gaucher disease (GD) patients. ...
The novel ITPR1 p.Phe2566Ser variant impairs IP3R1-mediated Ca2+ release and is associated with ataxia and miosis [0.03%]
ITPR1基因p.Phe2566Ser变异通过抑制IP3R1介导的钙释放与共济失调和缩瞳关联
Josephine Wincent,Songbai Zhang,Andrew Nolan et al.
Josephine Wincent et al.
Collagen and microvascular alterations contribute to neuromuscular degeneration and disease progression in chronic intestinal pseudo-obstruction [0.03%]
胶原蛋白和微血管改变对慢性肠梗阻的神经肌肉退行性变及疾病进展的作用
Elisa Boschetti,Irene Neri,Leonardo Caporali et al.
Elisa Boschetti et al.
Background: Chronic intestinal pseudo-obstruction (CIPO) is a severe gastrointestinal motility disorder that may be idiopathic or associated with systemic disease. In idiopathic cases, the pathophysiological mechanisms re...
Epigenetic analyses suggest different pathways during pregnancy for development of Type 1 diabetes in children with high versus low-neutral human leukocyte antigen-risk [0.03%]
表观遗传分析提示高人类白细胞抗原风险与低人类白细胞抗原风险儿童在妊娠期1型糖尿病发展的路径不同
Shamila D Alipoor,Angelica Ahrens,Julia Åkesson et al.
Shamila D Alipoor et al.
Background and objective: The development of Type 1 diabetes (T1D) is shaped by genetic predisposition and epigenetic regulation. Human leukocyte antigen (HLA) risk alleles are major genetic determinants, but the epigenet...
Colorectal cancer screening and incidence and mortality of colorectal and other cancers in the United Kingdom [0.03%]
英国结直肠癌筛查和结直肠癌及其他癌症的发病和死亡率
Marko Mandic,Fatemeh Safizadeh,Michael Hoffmeister et al.
Marko Mandic et al.
Perioperative immune checkpoint inhibitor therapy across tumors: Insights and shared lessons from a rapidly evolving field [0.03%]
围手术期免疫检查点抑制剂治疗（跨越不同肿瘤类型）：来自迅速发展的领域的启示与共性经验
Karl Björkström,Alexios Matikas,Fernanda Costa Svedman et al.
Karl Björkström et al.
The integration of immune checkpoint inhibitors into perioperative management marks a major evolution in curative-intent oncology. This review examines the current evidence for perioperative immunotherapy encompassing neoadjuvant, adjuvant,...
Long-term risk of acute pancreatitis in patients with celiac disease: A nationwide population-based cohort study [0.03%]
一项基于人群的队列研究：乳糜泻患者急性胰腺炎的长期风险
Jialu Yao,Jiangwei Sun,Fahim Ebrahimi et al.
Jialu Yao et al.
Background: Large-scale studies on the association between celiac disease (CeD) and acute pancreatitis (AP) are scarce. Objectives: To ...