Can the gut microbiome help 'digest' insomnia? A novel target in sleep medicine [0.03%]
肠道微生物组能帮助“消化”失眠吗？睡眠医学中的一个新目标
André P Pacheco,Christian Benedict
André P Pacheco
Fecal microbiota transplantation-based treatment protocol for chronic insomnia disorder: A randomized, double-blind, placebo-controlled trial [0.03%]
基于粪便菌群移植的慢性失眠障碍治疗方案：随机、双盲、安慰剂对照试验
Teng Gao,Xiaoxing Liu,Weifeng Mi et al.
Teng Gao et al.
Objective: Chronic insomnia disorder is common and burdensome, and current treatments remain limited. We conducted a multicenter, randomized, double-blind, placebo-controlled trial to determine whether a fecal microbiota ...
Targeting progressive multiple sclerosis: Toward mechanism-informed precision medicine [0.03%]
靶向进行性多发性硬化症：迈向基于机制的精准医学
Fredrik Piehl,Gonçalo Castelo-Branco,Maja Jagodic et al.
Fredrik Piehl et al.
Multiple sclerosis has undergone a therapeutic revolution over the past three decades. Randomized clinical trials and real-world data demonstrate that modern disease-modifying therapies substantially reduce relapse rates and acute inflammat...
Fabricated references are twice as common in medRxiv preprints as in peer-reviewed articles [0.03%]
与同行评审的文章相比，medRxiv预印本中的虚假参考文献是其两倍以上
Maxim Topaz,Zhihong Zhang,Pallavi Gupta et al.
Maxim Topaz et al.
Age-stratified effectiveness of a nurse-led heart failure programme: A population-based study [0.03%]
分年龄层的以护士为主导的心力衰竭项目的效果：一项基于人口的研究
Blanca Torres-Cardús,Emili Vela-Vallespín,David Monterde et al.
Blanca Torres-Cardús et al.
Aim: Old age is associated with poor outcomes in patients with heart failure (HF). This study aimed to assess the impact of age on the effectiveness of a new integrated, transition-based nurse-led HF programme in a health...
Anti-inflammatory agents in atherosclerosis-and a need for reform: Extraordinary claims require extraordinary evidence [0.03%]
动脉粥样硬化炎症治疗的证据危机：改革势在必行
Kevin Jon Williams
Kevin Jon Williams
Since 1858, human atherosclerotic plaques have been shown to contain immune cells. But are these cells suitable therapeutic targets? Dozens of clinical trials of anti-inflammatory agents other than colchicine have been performed in patients...
Edwin Cuppen
Edwin Cuppen
Expected survival is decreased in hereditary hemorrhagic telangiectasia: Results from a population-based registry study [0.03%]
遗传性出血性毛细血管扩张症患者的预期生存率下降：基于人群的注册研究结果
Cecilia Ahlström Emanuelsson,Anders Ehnhage,Mats Holmström et al.
Cecilia Ahlström Emanuelsson et al.
Background: Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant genetic disorder associated with substantial morbidity. Objectives: ...
Genomic Medicine Sweden: Advancing precision medicine at the national level [0.03%]
瑞典基因组医学：国家层面推进精准医疗
Anders Edsjö,Anna Lindstrand,Panagiotis Baliakas et al.
Anders Edsjö et al.
High-throughput sequencing has transformed clinical diagnostics of rare diseases (RD), cancer and infectious diseases by enabling the identification of disease-causing genetic alterations and facilitating individualised treatment and care. ...