Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management [0.03%]
冷球蛋白血症：分类、病理生理、临床表现和治疗的最新研究进展
Anna Linda Zignego,Laura Gragnani,Marcella Visentini et al.
Anna Linda Zignego et al.
Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoc...
Microscopic colitis is associated with an increased risk of dementia in a Swedish population [0.03%]
瑞典人口中的微小结肠炎与痴呆风险增加有关
Xiaoying Kang,David Bergman,Jiangwei Sun et al.
Xiaoying Kang et al.
Background: The microbiota-gut-brain axis has been implicated in dementia. Yet whether dementia is associated with microscopic colitis (MC), an age-related inflammatory colonic disease involving gut dysbiosis, remains unk...
Janus kinase and calcineurin-inhibitor combination in anti-MDA5 dermatomyositis: No significant survival benefit but reassuring safety profile [0.03%]
janus激酶和钙调神经磷酸酶抑制剂联合治疗抗MDA5皮肌炎：无法提高生存率，但安全性良好
Valentine Pagis,Quentin Astouati,Lucas Pacoureau et al.
Valentine Pagis et al.
Objectives: Anti-MDA5 dermatomyositis (anti-MDA5 DM) is the most severe subtype of dermatomyositis, due to its pulmonary involvement. Current treatment involves corticosteroids and immunosuppressants, but variability in r...
High BMI and low cardiorespiratory fitness in adolescence are associated with increased risk of severe bacterial infections in adulthood [0.03%]
青春期高的BMI和低的心肺适能与成年后严重细菌感染的风险增加有关
Birger Sourander,Kirsten Mehlig,Fredrik Olsen et al.
Birger Sourander et al.
Background: Obesity and poor physical fitness in youth are established risk factors for future cardiovascular disease and cancer. However, their potential impact on the risk of severe bacterial infections later in life re...
T cell-macrophage interactions in tuberculosis: What we've got here is failure to communicate [0.03%]
结核病小鼠模型中巨噬细胞和T细胞的相互作用：沟通失败
Rasmus Mortensen,Cecilia S Lindestam Arlehamn,Rhea N Coler et al.
Rasmus Mortensen et al.
Tuberculosis (TB) remains a leading infectious cause of morbidity and mortality, and the development of a new, highly effective vaccine would have a tremendous beneficial impact on global health. Although conventional memory CD4 and CD8 T c...
Jasmin Elkin,Chris Schilling,Michael W Hii et al.
Jasmin Elkin et al.
Maria Tydén,Gorav Batra,Bengt Fellström et al.
Maria Tydén et al.
Background: Renal dysfunction increases cardiovascular (CV) risk. We compared cystatin C-based estimated glomerular filtration rate (eGFRcys), creatinine-based eGFR (eGFRcr), and their ratio (eGFRcys/eGFRcr) in relation t...
New cases of δ-aminolevulinic acid dehydratase deficiency: Functional insights into gene variants using an innovative mouse liver model [0.03%]
δ-氨基乙酰丙酸脱水酶缺乏的新病例：利用创新的小鼠肝模型研究基因变异的功能效应
Elena Di Pierro,Isabel Solares,Daniel Jericó et al.
Elena Di Pierro et al.
Background: Dysfunction of δ-aminolevulinic acid dehydratase (ALAD), the second enzyme involved in heme biosynthesis, leads to two pathologies: genetic and acquired. The genetic form is an ultrarare, severe childhood-ons...
Metabolic and appetitive regulation of adipocyte mass during treatment of obesity [0.03%]
肥胖治疗过程中脂肪细胞质量的代谢和食欲调节
Jonathan Q Purnell,Carel W Le Roux
Jonathan Q Purnell
Adipose mass is homeostatically maintained within a narrow range despite fluctuations in daily calorie intake and activity levels. Constituting an adipose mass "set point," this homeostatic regulation includes sensing mechanisms in the form...
Colchicine and cardiovascular events: An updated meta-analysis of published randomized controlled trials [0.03%]
秋水仙碱与心血管事件：已发表的随机对照试验的最新Meta分析研究
Sining Xie,Federica Galimberti,Elena Olmastroni et al.
Sining Xie et al.
Background: Colchicine shows promise in reducing cardiovascular risk, but a recent study raised the question whether this is really the case. We conducted a meta-analysis of randomized controlled trials (RCTs) to assess i...