Voriconazole-induced severe skin allergy and neurological adverse event in a liver failure patient: A case report [0.03%]
肝功能衰竭患者伏立康唑致严重皮肤过敏及神经系统不良事件一例报告
Yun Lu,Wen-Jing Li,Su-Yu Gao et al.
Yun Lu et al.
What is known and objective: Triazole antifungal-associated severe skin allergy has received little attention. Here we report a case of an acute-on-chronic liver failure (ACLF) patient with diffused skin allergy pervading...
The association between empiric antimicrobial therapy and the risk of clinical failure in critically ill patients with aspiration pneumonia [0.03%]
经验性抗菌药物治疗与重症吸入性肺炎患者临床失败风险之间的关系
Jessica C Brumit,David B Cluck,Tabitha P Brown et al.
Jessica C Brumit et al.
What is known and object: Aspiration pneumonia is a clinically important infectious process that can result in increased morbidity and mortality. Empiric antimicrobial therapy with activity against anaerobes has been a st...
Hearing disorder following COVID-19 vaccination: A pharmacovigilance analysis using the Vaccine Adverse Event Reporting System [0.03%]
基于疫苗不良事件报告系统(VAERS)的COVID-19疫苗接种后听力障碍的药物警戒分析
Congqin Chen,Fang Fu,Lingqing Ding et al.
Congqin Chen et al.
What is known and objective: Evidence on whether the coronavirus disease 2019 (COVID-19) vaccination could cause hearing-related adverse events is still conflicting. This study aims to access the association between COVID...
Overexpression of NIMA related kinase 2 in multiple myeloma and its relevance with disease features and prognosis to bortezomib treatment [0.03%]
NIMA相关蛋白激酶2在多发性骨髓瘤中的高表达及其与临床特征和硼替佐米预后的关系
Xiaolin Gu,Zhenhua Wang,Qiqun Pan
Xiaolin Gu
What is known and objective: NIMA related kinase 2 (NEK2) promotes the malignant transformation and enhances the chemoresistance to proteasome inhibitor in multiple myeloma (MM) cell lines. The current study aimed to furt...
Impact of breakthrough trials on prescription trends of sodium-glucose cotransporter-2 inhibitors in Japan: An interrupted time-series analysis [0.03%]
日本钠-葡萄糖共转运蛋白2抑制剂处方趋势的突破性临床试验影响：一项中断时间序列分析
Ryo Iketani,Shinobu Imai
Ryo Iketani
What is known and objective: Sodium-glucose cotransporter-2 inhibitors (SGLT-2is) have been increasingly prescribed for the treatment of type 2 diabetes mellitus (T2DM). We aimed to investigate the impact of clinical tria...
Utilization of mechanistic modelling and simulation to analyse fenspiride proarrhythmic potency - Role of physiological and other non-drug related parameters [0.03%]
利用机制建模和模拟分析芬斯皮里德致心律失常作用力的作用-生理和其他非药物相关参数的作用
Barbara Wiśniowska,Mark Holbrook,Christopher Pollard et al.
Barbara Wiśniowska et al.
What is known and objective: Fenspiride, a drug that had been used for decades for the treatment of respiratory diseases, was recently withdrawn from the market due to the potential risk of QT prolongation and proarrhythm...
Antiretroviral drug-drug interactions: A comparison of online drug interaction databases [0.03%]
抗逆转录病毒药物相互作用：在线药物相互作用数据库比较分析
Emily N Drwiega,Melissa E Badowski,Sarah Michienzi
Emily N Drwiega
What is known and objective: Antiretrovirals have a high drug interaction potential, which can lead to increased toxicity and/or decreased efficacy. Multiple databases are available to assess drug-drug interactions. The a...
Level of therapeutic innovation from the registration studies of the new drugs for the prophylaxis of migraine [0.03%]
预防偏头痛新药注册研究中的治疗创新水平
Domenico Motola,Greta Santi Laurini,Giulia Bonaldo et al.
Domenico Motola et al.
What is known and objective: Migraine is one of the most prevalent and disabling medical illnesses. Preventive drugs are used to reduce the frequency, severity, and duration of attacks. Most patients were no longer on the...
Efficacy and safety of preoperative versus postoperative NSAIDs on pain relief in patients undergoing hip arthroscopy surgery: A multicentre, randomized, controlled trial [0.03%]
一项多中心随机对照研究：髋关节镜手术患者术前和术后使用非甾体类抗炎镇痛的疗效及安全性
Wei Zhang,Qian Zhao,Guang Yang et al.
Wei Zhang et al.
What is known and objective: Postoperative pain relief is a critical issue for hip arthroscopy surgery (HAS). This study aimed to investigate the effect of preemptive non-steroidal anti-inflammatory drugs (NSAIDs) for pos...
Randomized Controlled Trial
Journal of clinical pharmacy and therapeutics. 2022 Dec;47(12):2091-2100. DOI:10.1111/jcpt.13755 2022
Antibiotic use during the first 6 months of COVID-19 pandemic in Iran: A large-scale multi-centre study [0.03%]
伊朗第一波疫情期间6个月内抗生素使用情况的多中心大规模研究
Mohammadreza Salehi,Hossein Khalili,Arash Seifi et al.
Mohammadreza Salehi et al.
What is known and objective: Although antibiotics are ineffective against viral infections, epidemiological studies have revealed that the COVID-19 pandemic resulted in the overuse of antibiotics and disruption of antimic...