Influence of genetic variants on remifentanil sensitivity in Chinese women [0.03%]
基因变异对中国女性瑞芬太尼敏感性的影响
Haojie Niu,Shuai Zhao,Yafeng Wang et al.
Haojie Niu et al.
What is known and objective: Significant individual differences have been observed in pain sensitivity and analgesic effect of opioids. Previous studies have shown that genetic factors contributed to analgesics requiremen...
Kaan Aslan,Ömer Kiliç,Eylem Kiral et al.
Kaan Aslan et al.
What is known and objective: The frequency of multidrug-resistant bacterial infections is increasing worldwide. Tigecycline may be an important option for children with life-threatening nosocomial infections due to multid...
Comparing analgesic efficacy of the regional block with different-volume ropivacaine after a modified radical mastectomy [0.03%]
不同剂量罗哌卡因胸肌皮下阻滞用于改良根治乳房切除术后镇痛的效果比较
Yu-Jing Yuan,Fu-Shan Xue,Tian Tian
Yu-Jing Yuan
The effect of chemotherapy on survival in oldest old patients with nonmetastatic triple negative breast cancer: A populationbased observational study [0.03%]
化疗对非转移性三阴性乳腺癌老年患者生存率影响的基于人口的观察性研究
Bing Wu,Congcong Sun,Xiaoqin Sun et al.
Bing Wu et al.
What is known and objective: Chemotherapy is the primary pharmacotherapy of triple-negative breast cancer (TNBC). But the benefit of adjuvant chemotherapy in the oldest old TNBC patients remains controversial. Hence, we d...
Observational Study
Journal of clinical pharmacy and therapeutics. 2022 Nov;47(11):1826-1836. DOI:10.1111/jcpt.13776 2022
Rapid infusion of infliximab biosimilars and the incidence and severity of infusion-related reactions in patients with inflammatory bowel disease [0.03%]
英夫利西单抗类似药快速输注与炎症性肠病患者输注相关反应的发生率及严重程度的关系
Caroline Rusch,Marci Wood,Amanda G Kennedy et al.
Caroline Rusch et al.
What is known and objective: Infliximab is an anti-tumour necrosis factor agent used in the treatment of inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. While the use of infliximab...
Predicting the effect of sirolimus on disease activity in patients with systemic lupus erythematosus using machine learning [0.03%]
使用机器学习预测西罗莫司对系统性红斑狼疮患者疾病活动度的影响
Dong-Dong Wang,Ya-Feng Li,Cun Zhang et al.
Dong-Dong Wang et al.
What is known and objectives: The present study aimed to predict the effect of sirolimus on disease activity in patients with systemic lupus erythematosus (SLE) using machine learning and to recommend appropriate sirolimu...
Men who have sex with men is the high-risk drug resistance population: A meta-analysis of HIV-1 drug resistance profiles and trends in China [0.03%]
MSM是高风险的耐药药物人群：中国HIV-1耐药性状况及趋势的meta分析
Defu Yuan,Yangyang Liu,Ying Zhou et al.
Defu Yuan et al.
What is known and objective: Except for the transmitted drug resistance (TDR)'s standard sampling and monitoring protocol, China's HIV-1 pretreatment drug resistance (PDR) and acquired drug resistance (ADR) results vary w...
14-day famciclovir treatment significantly reduces the incidence of postherpetic neuralgia in elderly patients with herpes zoster [0.03%]
为期2周的 Famciclovir 治疗可显著降低老年带状疱疹患者的带状疱疹后神经痛发生率
Jie Kong,Huiping Wang,Yuanjun Liu et al.
Jie Kong et al.
What is known and objective: Pain is the main symptom of herpes zoster (HZ), whilst postherpetic neuralgia (PHN) is a long-term unbearable pain, which seriously affects the quality of life of patients and is also the most...
Hyperkalaemia and potassium binders: Retrospective observational analysis looking at the efficacy and cost effectiveness of calcium polystyrene sulfonate and sodium zirconium cyclosilicate [0.03%]
高钾血症与钾结合剂：关于聚苯磺酸钙和环硅酸锆钠的有效性和成本效益的回顾性观察分析
Abdullah Bin Huda,Charlotte Langford,James Lake et al.
Abdullah Bin Huda et al.
What is known and objective: Hyperkalaemia is a common medical emergency in patients admitted to hospital. There is a limited evidence base supporting some of the commonly applied treatment strategies. Although, NICE has ...
Observational Study
Journal of clinical pharmacy and therapeutics. 2022 Dec;47(12):2170-2175. DOI:10.1111/jcpt.13766 2022
Population pharmacokinetics and dosing optimization of olanzapine in Chinese paediatric patients: Based on the impact of sex and concomitant valproate on clearance [0.03%]
基于性别和合并使用丙戊酸对清除率影响的中国儿童患者奥氮平药代动力学及剂量优化
Tao Xiao,Jin-Qing Hu,Shu-Jing Liu et al.
Tao Xiao et al.
What is known and objective: Olanzapine is an atypical antipsychotic drug used for mental disorders. There are limited studies providing sufficient pharmacokinetic data, thus the variability of concentrations of olanzapin...