Autoantibodies directed against glutamate decarboxylase interfere with glucose-stimulated insulin secretion in dispersed rat islets [0.03%]
抗谷氨酸脱羧酶自身抗体干扰散在胰岛的葡萄糖刺激的胰岛素分泌作用
Varun Kamat,Jared R Radtke,Qingxun Hu et al.
Varun Kamat et al.
Islet autoantibodies, including autoantibodies directed against the 65kDa isoform of glutamate decarboxylase (GAD65Ab), are present in the majority of patients with newly diagnosed type 1 diabetes (T1D). Whereas these autoantibodies are his...
Investigation of the effect of metoclopramide on proliferation signal molecules in breast tissue [0.03%]
胃复安对乳腺组织增殖信号分子的影响研究
Nurcan Umur,Selda İldan Çalım,Gülce Naz Yazıcı et al.
Nurcan Umur et al.
Metoclopramide (MCP) is a drug that has been widely used in recent years due to its hyperprolactinaemia effect on mothers during breastfeeding. The aim of this study was to investigate the proliferative changes that MCP may cause in the mat...
High-altitude hypoxia-induced rat alveolar cell injury by increasing autophagy [0.03%]
高空低氧诱导的大鼠肺泡细胞自噬增加及其损伤作用
Zhen Zhao,Bin Hou,Li Tang et al.
Zhen Zhao et al.
Autophagy has been implicated in the pathogenesis of various lung diseases. This study aimed to investigate the role of autophagy in lung injury induced by high-altitude hypoxia. Wistar rats were randomized into four groups for exposure to ...
DNA methylation and miRNA expression in colon adenomas compared with matched normal colon mucosa and carcinomas [0.03%]
结肠腺瘤与正常结肠粘膜和癌组织的DNA甲基化和miRNA表达情况比较研究
Mezgebe Gebrekiristos,Joshua Melson,Alice Jiang et al.
Mezgebe Gebrekiristos et al.
Dysregulation of DNA methylation patterns and non-coding RNA, including miRNAs, has been implicated in colon cancer, and these changes may occur early in the development of carcinoma. In this study, the role of epigenetics as early changes ...
Juliana Cristina de Souza,Victor Coutinho Bastos,Núbia Braga Pereira et al.
Juliana Cristina de Souza et al.
Previously, by employing 3D organotypic tissue culture and patient-derived xenograft (PDX) model, oral myxoma response to a MAPK/MEK inhibitor was observed. Gross examination of the tumour fragments obtained after 55 days of PDX grafting re...
Orchestrated expression of vasculogenic mimicry and laminin-5γ2 is an independent prognostic marker in oral squamous cell carcinoma [0.03%]
血管生成模仿和层粘连蛋白-5γ2的协同表达是口腔鳞癌的独立预后标志物
Depanwita Saha,Debarpan Mitra,Neyaz Alam et al.
Depanwita Saha et al.
Vasculogenic mimicry (VM), an endothelial cell-independent alternative mechanism of blood supply to the malignant tumour, has long been considered as an adverse prognostic factor in many cancers. The correlation of VM with laminin-5γ2 and ...
Remifentanil reduces the proliferation, migration and invasion of HCC cells via lncRNA NBR2/miR-650/TIMP3 axis [0.03%]
瑞芬太尼通过lncRNA NBR2/miR-650/TIMP3轴抑制肝癌细胞增殖、迁移和侵袭
Wei Liang,Jinyuan Ke
Wei Liang
Cancer cell hyperproliferation and metastasis are major causes of cancer-associated mortality. Although the use of anaesthetics and analgesics may affect cancer cell metastasis, the underlying molecular mechanism remains unclear. This study...
Anna L Gray,Nabina Pun,Amanda J L Ridley et al.
Anna L Gray et al.
Leucocyte recruitment is a critical component of the immune response and is central to our ability to fight infection. Paradoxically, leucocyte recruitment is also a central component of inflammatory-based diseases such as rheumatoid arthri...
NLRC5 enhances autophagy via inactivation of AKT/mTOR pathway and ameliorates cardiac hypertrophy [0.03%]
NLRC5通过失活AKT/mTOR通路促进自噬并改善心脏肥大
Bayinsilema Ba,Abudoukelimu Mayila,Yankai Guo et al.
Bayinsilema Ba et al.
The aim of this study was to investigate the effect of nucleotide-binding oligomerization domain (NOD)-like receptor family CARD domain containing 5 (NLRC5) in cardiac hypertrophy, and to explore the mechanism implicated in this effect Card...