Lysosomal acid lipase over-expression disrupts lamellar body genesis and alveolar structure in the lung [0.03%]
溶酶体酸性脂酶过表达干扰肺泡结构和板层小体的形成
Yuan Li,Yulin Qin,Huimin Li et al.
Yuan Li et al.
The functional role of neutral lipids in the lung is poorly understood. Lysosomal acid lipase (LAL) is a critical enzyme in hydrolysis of cholesteryl esters and triglycerides to generate free fatty acids and cholesterol in lysosomes. Human ...
Laser capture microdissection reveals dose-response of gene expression in situ consequent to asbestos exposure [0.03%]
激光捕获微解剖技术显示了因石棉暴露而引起的原位基因表达剂量效应关系
Qi Yin,Arnold R Brody,Deborah E Sullivan
Qi Yin
The genes that mediate fibroproliferative lung disease remain to be defined. Prior studies from our laboratory showed by in situ hybridization and immunohistochemistry that the genes coding for tumour necrosis factor alpha, transforming gro...
Pathology and virus dispersion in cynomolgus monkeys experimentally infected with severe acute respiratory syndrome coronavirus via different inoculation routes [0.03%]
不同途径感染所致猕猴实验性严重急性呼吸综合征冠状病毒病理与病毒扩散分布规律的研究
Noriyo Nagata,Naoko Iwata,Hideki Hasegawa et al.
Noriyo Nagata et al.
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) causes SARS. The pathogenic mechanisms of SARS-CoV remain poorly understood. Six cynomolgus monkeys were inoculated with the HKU39849 isolate of SARS-CoV via four routes. A...
Prenatal administration of vitamin A alters pulmonary and plasma levels of vascular endothelial growth factor in the developing mouse [0.03%]
维生素A的宫内干预通过改变血管内皮生长因子水平影响胎鼠肺发育
Maria de Lurdes Pinto,Paula Rodrigues,Ana Cláudia Coelho et al.
Maria de Lurdes Pinto et al.
Vitamin A and the retinoids play a unique role in mammalian embryonic and foetal development and are essential for both cellular differentiation and the establishment of normal morphogenesis. Vascular endothelial growth factor (VEGF) is a k...
Toll-like receptor and tumour necrosis factor dependent endotoxin-induced acute lung injury [0.03%]
toll样受体和肿瘤坏死因子依赖的内毒素诱导的急性肺损伤
Dieudonnée Togbe,Silvia Schnyder-Candrian,Bruno Schnyder et al.
Dieudonnée Togbe et al.
Recent studies on endotoxin/lipopolysaccharide (LPS)-induced acute inflammatory response in the lung are reviewed. The acute airway inflammatory response to inhaled endotoxin is mediated through Toll-like receptor 4 (TLR4) and CD14 signalli...
Sensitivity to Escherichia coli Nissle 1917 in mice is dependent on environment and genetic background [0.03%]
鼠对大肠杆菌Nissle 1917的敏感性取决于环境和遗传背景
Andre Bleich,John P Sundberg,Anna Smoczek et al.
Andre Bleich et al.
Escherichia coli Nissle 1917 (EcN) is a well-characterized probiotic bacterium. Although genomic comparisons of EcN with the uropathogenic E. coli strain CFT073 revealed high degrees of similarity, EcN is generally considered a non-pathogen...
Role of p38 mitogen-activated protein kinase pathway on heart failure in the infant rat after burn injury [0.03%]
p38丝裂原活化蛋白激酶途径在烧伤后幼年大鼠心力衰竭中的作用研究
Toshiro Kita,Midori Ogawa,Hiroaki Sato et al.
Toshiro Kita et al.
We examined the hypothesis that post-burn activation of the p38 mitogen-activated protein kinase (MAPK) pathway is one aspect of the signalling cascade culminating in post-burn secretion of tumour necrosis factor (TNF)-alpha which contribut...
Oestrogen supplementation following castration promotes stromal remodelling and histopathological alterations in the Mongolian gerbil ventral prostate [0.03%]
去势后补充雌二醇可促进蒙古沙鼠腹侧前列腺间质重塑和组织病理学改变
Wellerson Rodrigo Scarano,Daniel Emídio de Sousa,Silvana Gisele Pegorin Campos et al.
Wellerson Rodrigo Scarano et al.
The effect of oestradiol on the intact and castrated adult gerbil prostate was evaluated by focussing on stromal and epithelial disorders, and hormonal receptor immunoreactivity. The experimental animals were studied by histological, histoc...
Comparison of metastatic brain tumour models using three different methods: the morphological role of the pia mater [0.03%]
三种不同方法构建的脑转移瘤模型的比较：软膜的作用机制
Norihiko Saito,Tsutomu Hatori,Nozomu Murata et al.
Norihiko Saito et al.
As methods of cancer diagnosis and treatment progress, interest in metastatic brain tumours continues to increase. There are many studies using various methods of animal model and we considered that each model reflects different pathologica...