Panx1 knockout promotes preneoplastic aberrant crypt foci development in a chemically induced model of mouse colon carcinogenesis [0.03%]
胰腺癌基因敲除通过促进化学诱导的小鼠结肠肿瘤发生模型中的癌前异常隐窝病灶的发展来促进结肠肿瘤发生发展
Sara Gomes Espírito Santo,Tereza Cristina Da Silva,Bruno Cogliati et al.
Sara Gomes Espírito Santo et al.
Colorectal cancer, which is the third leading cause of cancer-related deaths worldwide, is a multistep disease, featuring preneoplastic aberrant crypt foci (ACF) as the early morphological manifestation. The roles of hemichannel-forming tra...
Nek6 knockdown polarized macrophages into a pro-inflammatory phenotype via inhibiting STAT3 expression [0.03%]
Nek6敲低通过抑制STAT3表达使极化巨噬细胞向促炎表型转变
Xiaoyan Wu,Ke-Qiong Deng,Huan-Huan Cai et al.
Xiaoyan Wu et al.
Recently macrophage polarization has emerged as playing an essential role in the oathogenesis of atherosclerosis, which is the most important underlying process in many types of cardiovascular diseases. Although Nek6 has been reported to be...
mRNA expression profile reveals differentially expressed genes in splenocytes of experimental autoimmune encephalomyelitis model [0.03%]
基于寡核苷酸阵列的实验性自身免疫性脑脊髓炎模型脾细胞基因表达谱分析
Arshad Mehmood,Shuang Song,Xiaochen Du et al.
Arshad Mehmood et al.
Experimental autoimmune encephalomyelitis (EAE) is a mouse model that can be used to investigate aetiology, pathogenesis, and treatment approaches for multiple sclerosis (MS). A novel integrated bioinformatics approach was used to understan...
Mechanism of the HIF-1α/VEGF/VEGFR-2 pathway in the proliferation and apoptosis of human haemangioma endothelial cells [0.03%]
HIF-1α/VEGF/VEGFR-2信号通路在血管瘤内皮细胞增殖及凋亡中的作用机制研究
Wenpei Zhang,Lei Sun,Hongxia Gao et al.
Wenpei Zhang et al.
Haemangiomas (HAs) are prevalent vascular endothelial cell tumours. With respect to the possible involvement of HIF-1α in HAs, we have explored its role in haemangioma endothelial cell (HemEC) proliferation and apoptosis. shRNA HIF-1α and...
A prognostic model based on regulatory T-cell-related genes in gastric cancer: Systematic construction and validation [0.03%]
基于胃癌调节性T细胞相关基因的预后模型的系统构建与验证
Qin Tong,Yingjie Ling
Qin Tong
Human gastrointestinal tumours have been shown to contain massive numbers of tumour infiltrating regulatory T cells (Tregs), the presence of which are closely related to tumour immunity. This study was designed to develop new Treg-related p...
Ioannis Papaioannou,James S Owen,Rafael J Yáñez-Muñoz
Ioannis Papaioannou
Rare diseases collectively exact a high toll on society due to their sheer number and overall prevalence. Their heterogeneity, diversity, and nature pose daunting clinical challenges for both management and treatment. In this review, we dis...
RUNX1 promotes liver fibrosis progression through regulating TGF-β signalling [0.03%]
RUNX1通过调节TGF-β信号促进肝纤维化进展
Zhaoyang Guo,Xinxin Liu,Shulei Zhao et al.
Zhaoyang Guo et al.
Liver fibrosis is caused by chronic liver injury. There are limited treatments for it, and the pathogenesis is unclear. Therefore, there is an urgent need to explore the pathogenesis of liver fibrosis, and to try to identify new potential t...
Abnormal expression and role of MicroRNA-214-3p/SLC8A1 in neonatal Hypoxic-Ischaemic encephalopathy [0.03%]
微调素-214-3p/SLC8A1在新生儿缺氧缺血性脑病中异常表达及其作用
Liu Yang,Li Zhang,Jing Zhu et al.
Liu Yang et al.
Neonatal hypoxic-ischaemic encephalopathy (HIE) refers to brain damage caused by intra-uterine distress and asphyxia/hypoxia during the perinatal and neonatal periods. MicroRNA (MiR)-214-3p plays a critical role in cell growth and apoptosis...
High density of FOXP3 predicts better prognosis in germinal and non-germinal centre diffuse large B-cell lymphoma [0.03%]
FOXP3高表达预示着生发中心和非生发中心弥漫大B细胞淋巴瘤的良好预后
Asmaa M Ahmed,Sally S Abdel-Hakeem,Maged A F Amine et al.
Asmaa M Ahmed et al.
This study highlights the prognostic impact of FOXP3 and CD68 expression in DLBCL, NOS and in its GCB and non-GCB subtypes. This may help the development of individualized therapy, prognostic prediction and therapy stratification. ...
Arginine vasopressin deficiency and conivaptan (a V1a-V2 receptor antagonist) treatment reverses liver damage and fibrosis in rats with chronic portocaval anastomosis [0.03%]
精氨酸血管加压素缺乏和利钠肽(V1a-V2受体拮抗剂)治疗可逆转慢性门腔分流术大鼠肝损伤及纤维化
Yesenia Danyeli Navarro-Gonzalez,Javier Ventura-Juarez,Martín Humberto Muñoz-Ortega et al.
Yesenia Danyeli Navarro-Gonzalez et al.
Arginine vasopressin (AVP) is a naturally occurring hormone synthesized in the hypothalamus. AVP demonstrates pro-fibrotic effects as it stimulates hepatic stellate cells to secrete transforming growth factor-β (TGF-β) and collagen. Previ...