Zinc transporter ZnT5 is associated with epithelial mesenchymal transition via SMAD1 in breast cancer [0.03%]
锌转运蛋白ZnT5通过SMAD1与乳腺癌上皮间质转化相关联
Erina Iwabuchi,Yasuhiro Miki,Junyao Xu et al.
Erina Iwabuchi et al.
Zinc levels in breast cancer tissues have been reported to be higher than those in normal tissues. In addition, the expression levels of zinc transporters, including ZnT5 and ZnT6, are reportedly higher in breast cancer than in normal breas...
Feline hypertrophic cardiomyopathy: Does the microRNA-mRNA regulatory network contribute to heart sarcomeric protein remodelling? [0.03%]
肥厚型心肌病中的微小核糖核酸-信使核糖核酸调控网络是否参与心脏收缩蛋白重塑？
Gabriella Guelfi,Noemi Venanzi,Camilla Capaccia et al.
Gabriella Guelfi et al.
Feline primary hypertrophic cardiomyopathy (HCM) is an intrinsic myocardial disease characterized by concentric hypertrophy of the left ventricle. In the present study, we investigated the microRNA-mRNA regulatory network in feline myocardi...
GABRP inhibits the progression of oesophageal cancer by regulating CFTR: Integrating bioinformatics analysis and experimental validation [0.03%]
GABRP通过调节CFTR抑制食管癌进展：生物信息学分析与实验验证整合研究
Jingzhi Zhang,Xue Liu,Ling Zeng et al.
Jingzhi Zhang et al.
Oesophageal cancer (EC) is a malignancy which accounts for a substantial number of cancer-related deaths worldwide. The molecular mechanisms underlying the pathogenesis of EC have not been fully elucidated. GSE17351 and GSE20347 data sets f...
Muscle fibre morphometric analysis (MusMA) correlates with muscle function and cardiovascular risk prognosis [0.03%]
肌肉形态分析（MusMA）与肌肉功能和心血管风险预后相关性研究
Larisse Longo,Bárbara Jonson Bartikoski,Valessa Emanoele Gabriel de Souza et al.
Larisse Longo et al.
Morphometry of striated muscle fibres is critical for monitoring muscle health and function. Here, we evaluated functional parameters of skeletal and cardiac striated muscle in two experimental models using the Morphometric Analysis of Musc...
Microfluidics-based EGFR mutation detection and its implication in the resource-limited clinical setting [0.03%]
基于微流控技术的EGFR突变检测及其在临床资源受限环境中的应用
Pradnya Joshi,Prachi Gogte,Trupti Pai et al.
Pradnya Joshi et al.
Management of lung cancer today obligates a mutational analysis of the epidermal growth factor receptor (EGFR) gene particularly when Tyrosine Kinase Inhibitor (TKI) therapy is being considered as part of prognostic stratification. This stu...
Trilobatin contributes to the improvement of myopathy in a mouse model of Duchenne muscular dystrophy [0.03%]
三花异黄素有助于杜氏肌营养不良小鼠模型肌肉病的改善
Túlio de Almeida Hermes,Paula Fratini,Beatriz Godinho Nascimento et al.
Túlio de Almeida Hermes et al.
Duchenne muscular dystrophy (DMD) occurs due to genetic mutations that lead to a deficiency in dystrophin production and consequent progressive degeneration of skeletal muscle fibres, through oxidative stress and an exacerbated inflammatory...
TGFβR1 inhibition drives hepatocellular carcinoma proliferation through induction of toll-like-receptor signalling [0.03%]
TGFβR1抑制通过诱导 Toll 样受体信号传导促进肝细胞癌增殖
Fatma El Zahraa Ammar Mohamed,Bedair Dewidar,Tao Lin et al.
Fatma El Zahraa Ammar Mohamed et al.
Transforming growth factor (TGF)-β and toll-like receptors (TLRs) have been shown to independently modulate the proliferation of hepatocellular carcinoma (HCC). Since a direct cross-talk between these two signalling pathways in HCC has not...
MiR-22-3p facilitates bone marrow mesenchymal stem cell osteogenesis and fracture healing through the SOSTDC1-PI3K/AKT pathway [0.03%]
MiR-22-3p通过SOSTDC1-PI3K/AKT通路促进骨髓间充质干细胞成骨和骨折愈合
Chunqiu Wang,Xinguo Wang,Hui Cheng et al.
Chunqiu Wang et al.
Bone fractures are the most common form of musculoskeletal trauma worldwide. Numerous microRNAs (miRNAs) have been suggested to be participants in regulating bone-related diseases. Recent studies revealed the regulatory role of miR-22-3p in...