KLF9 aggravates the cardiomyocyte hypertrophy in hypertrophic obstructive cardiomyopathy through the lncRNA UCA1/p27 axis [0.03%]
KLF9通过lncRNA UCA1/p27轴促进肥厚性梗阻性心肌病中心肌细胞的肥大加重
Dayou Ding,Guangrong Zhao
Dayou Ding
Cardiac hypertrophy refers to an abnormal increase in the thickness of the heart muscle. Our study explores the role of Krüppel-like factor 9 (KLF9) in hypertrophic obstructive cardiomyopathy (HOCM)-induced cardiomyocyte hypertrophy, provi...
Silencing long non-coding RNA linc00689 suppresses the growth and invasion of osteosarcoma cells by targeting miR-129-5p/NUSAP1 [0.03%]
长链非编码RNA linc00689通过靶向miR-129-5p/NUSAP1促进骨肉瘤细胞生长和侵袭的调控机制研究
Ling Zhang,Jingtao Song,Xin Xu et al.
Ling Zhang et al.
Long non-coding RNAs (lncRNAs) have been reported to play a critical role in the progression and metastasis of osteosarcoma. Recently, long intergenic non-protein coding RNA 689 (linc00689) has been shown to be involved in glioma. However, ...
Review of methodology and re-analysis of lipidomic data focusing on specialised pro-resolution lipid mediators (SPMs) in a human model of resolving inflammation [0.03%]
对人类炎症消退模型中专业 resolves 炎症脂质介质(SPMs) 的脂质组学数据的重新分析及其方法学回顾
Natalie Z M Homer,Ruth Andrew,Derek W Gilroy
Natalie Z M Homer
Using a model of UV-killed E. coli driven dermal inflammation in healthy human volunteers, we originally reported that following inflammatory resolution there was infiltration of macrophages, which, through prostanoids including prostagland...
Identification of BCL3 as a biomarker for chondrocyte programmed cell death in osteoarthritis [0.03%]
BCL3作为软骨细胞程序性死亡的骨关节炎生物标志物鉴定研究
Junxiao Ren,Rui Li,Chen Meng et al.
Junxiao Ren et al.
Osteoarthritis (OA) is a condition that is widely prevalent and causes joint pain and disability, with programmed cell death (PCD) playing a role in its pathogenesis. This study aimed to identify biomarkers associated with PCD in OA and exp...
Perinatal exposure to lead alters male reproductive behaviour and immunoreactivity of androgen and oestrogen receptors in the brain [0.03%]
孕期接触铅可改变雄性的生殖行为及大脑中雄激素和雌激素受体的免疫反应性
Marcela Arteaga-Silva,Rosa María Vigueras-Villaseñor,Gustavo Guillen-Herrera et al.
Marcela Arteaga-Silva et al.
Lead (Pb) exposure during perinatal development alters testosterone (T) concentrations and delays puberty in children and laboratory rodents. In addition, exposure to the metal during adult life decreases T and libido in men and affects mal...
Histomorphometric analysis of excisional cutaneous wounds with different diameters in an animal model [0.03%]
一种动物模型中不同直径切除皮肤伤口的组织形态计量学分析
Janiele Staianov,Jeiciele Mayara Rodrigues Struz,Rafaela Viana Vieira et al.
Janiele Staianov et al.
The skin wound model in rats is a fundamental stage in preclinical trials, but there is a lack of standardization in these trials regarding the initial wound area, making analysis and comparison between studies difficult. Therefore, this st...
Determination of osteopontin in monitoring retinal damage in metabolic syndrome [0.03%]
骨基质蛋白在代谢综合征视网膜损伤监测中的作用研究
Ramona D&#x;Amico,Rosalba Siracusa,Marika Cordaro et al.
Ramona D&#x;Amico et al.
Metabolic syndrome (MetS) is becoming an increasing public health challenge. Many of the individual components of MetS are associated with ocular changes, but it is not yet clear what the association is. It is known that MetS can lead to di...
Enhanced hepatoprotective effects of empagliflozin and vitamin D dual therapy against metabolic dysfunction-associated steatohepatitis in mice by boosted modulation of metabolic, oxidative stress, and inflammatory pathways [0.03%]
通过增强代谢、氧化应激和炎症途径的调节，恩格列净和维生素D双重治疗在小鼠代谢功能障碍相关steatohepatitis中的增强肝保护作用
Wesam F Farrash,Shakir Idris,Mohamed E Elzubier et al.
Wesam F Farrash et al.
Although single treatment with sodium-glucose cotransporter-2 inhibitors (SGLT2i) or vitamin D3 (VD3) inhibited metabolic dysfunction-associated steatohepatitis (MASH) development in diabetic patients, their combination has not been explore...
Thrombospondins: Conserved mediators and modulators of metazoan extracellular matrix [0.03%]
保守的作用于后生动物细胞外基质的血小板源性生长因子家族成员—— thrombospondin（TSP)
Josephine C Adams
Josephine C Adams
This review provides a personal overview of significant scientific developments in the thrombospondin field during the course of my career. Thrombospondins are multidomain, multimeric, calcium-binding extracellular glycoproteins with contex...
Renal protective roles of macrophage matrix metalloproteinase-12 in mice with obstructed kidneys [0.03%]
巨噬细胞基质金属蛋白酶-12在尿路梗阻鼠肾保护中的作用
Shunichiro Hanai,Daiki Nakagomi,Kotaro Suzuki et al.
Shunichiro Hanai et al.
Matrix metalloproteinase (MMP)-12 has been reported to have diverse functions, including regulation of immune reactions and anti-inflammatory effects, but the potential roles of MMP-12 in kidney injury have not been fully elucidated. This s...