Flow cytometry-guided ex vivo drug sensitivity testing informs venetoclax-based therapy in acute undifferentiated leukaemia [0.03%]
流式细胞术引导的体外药物敏感性试验指导伏立诺他联合苯达莫斯汀和维奈克拉治疗急性未分化白血病患者
Lei Xu,Jun Wang,Wen Zhao et al.
Lei Xu et al.
Improved survival with fludarabine-based therapies in mixed phenotype acute leukaemia: A population-based study using the WHO 2022 classification [0.03%]
基于氟达拉滨的治疗在混合表型急性白血病中的生存优势：使用WHO 2022分类的大群体研究
Lisa-Maj Christensen,Mikkel Runason Simonsen,Jonas Faartoft Jensen et al.
Lisa-Maj Christensen et al.
Mixed phenotype acute leukaemia (MPAL) is a rare subtype of acute leukaemia possessing significant therapeutic challenges, as no standardized, evidence-based treatment regimen has been defined. In this nationwide study, we aimed to assess t...
A rare chain of events: Post-follicular therapy-related t(8;21) acute myeloid leukaemia with KIT D816Y mutation revealing systemic mastocytosis [0.03%]
罕见的链式事件：具有KIT D816Y突变的治疗相关t（8;21）急性髓系白血病，揭示了全身性嗜酸细胞增生症
Clara Assadi-Gazvini,Quentin Amiot,Lucie Menier et al.
Clara Assadi-Gazvini et al.
A genetic risk score based on BCL11A and HBS1L-MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients [0.03%]
基于BCL11A和HBS1L-MYB变异的遗传风险评分可预测巴西镰状细胞贫血患者的临床严重程度
Gabriela S Arcanjo,Alexsandro P Silva,Madi V Diniz et al.
Gabriela S Arcanjo et al.
Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co-inheritance of gen...
Chimeric antigen receptor T cells for autoimmune diseases, in particular immune thrombocytopenia [0.03%]
用于自身免疫病的嵌合抗原受体T细胞治疗，特别是免疫性血小板减少症
Samuel P Soff,Samuel Ruder,James B Bussel
Samuel P Soff
Immune thrombocytopenia (ITP) is characterized by immune-mediated platelet destruction and impaired platelet production. Both plasma/B cell-producing anti-platelet autoantibodies and autoreactive T cells lead to thrombocytopenia and treatme...
Distribution of adult T-cell leukaemia/lymphoma subtypes and survival outcomes across geographical regions: An international retrospective cohort study [0.03%]
成人T细胞白血病/淋巴瘤亚型的地域分布及预后：一项国际回顾性队列研究
Bryan Valcarcel,Atae Utsunomiya,Maki Otsuka et al.
Bryan Valcarcel et al.
Although adult T-cell leukaemia/lymphoma (ATL) has a higher burden in certain world regions, outcomes have not been directly compared across regions. We conducted a multicentre cohort study comparing the distribution of ATL subtypes and ove...
Decreased renal function predicts severe cytokine release syndrome after CAR-T-cell therapy for large B-cell lymphoma [0.03%]
CAR-T细胞治疗大B细胞淋巴瘤后，肾功能下降预示着严重的细胞因子释放综合征
Yasuyuki Arai,Tomoyasu Jo,Takayuki Sato et al.
Yasuyuki Arai et al.
Cytokine release syndrome (CRS) remains a major toxicity of chimeric antigen receptor (CAR) T-cell therapy in large B-cell lymphoma (LBCL), and robust pre-infusion predictors are needed for risk-adapted management. We retrospectively analys...
MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia [0.03%]
microRNA可能参与免疫调节障碍及巨核细胞功能异常导致的免疫性血小板减少症发病机制
Zhenyu Liu,Johan Rebetz,Lamya Garabet et al.
Zhenyu Liu et al.
Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phago...
Inclusion of Thiotepa in Myeloablative Regimens Improves Donor Chimerism in Children with Inborn Errors of Immunity or Inherited Metabolic Disorders [0.03%]
硫替派用于重型免疫缺陷或遗传性代谢病预处理方案可提高儿童供者嵌合率
Caitlyn McComb,Vinita Pai,Joseph Stanek et al.
Caitlyn McComb et al.
Marco P Barros Pinto
Marco P Barros Pinto