Mega-dose decitabine conditioning and prophylactic donor lymphocyte infusion for patients with relapsed/refractory AML with active disease at the time of allogeneic haematopoietic cell transplantation: A multicenter prospective phase II study [0.03%]
大剂量地西他滨预处理及预防性输注供者淋巴细胞治疗allo-HSCT时病情进展的复发/难治性急性髓系白血病患者的多中心前瞻性Ⅱ期研究
Meng Lv,Chen-Hua Yan,Rui Ma et al.
Meng Lv et al.
Patients with relapsed/refractory acute myeloid leukaemia (R/R AML), especially those who failed in novel target agents are related to dismal survival. We developed a multi-institutional, single-arm, prospective phase II trial, to investiga...
Clinical Trial
British journal of haematology. 2024 Nov;205(5):1910-1920. DOI:10.1111/bjh.19781 2024
Joleen Choy,Katharine L Lewis
Joleen Choy
In their paper, Pinto et al. report findings from the Italian URBAN study; an ambispective, observational, multicentre study evaluating the safety and efficacy of obinutuzumab-based therapy for advanced stage follicular lymphoma (FL) in rou...
Apoptosis and platelet biogenesis: A new piece of information on a debated topic [0.03%]
凋亡与血小板生成：一个争论话题的新信息片段
Carlo Zaninetti,Andreas Greinacher
Carlo Zaninetti
Thrombocytopenia 4 (THC4) is an extremely rare form of inherited thrombocytopenia caused by mutations in the gene encoding cytochrome c (CYCS). The mechanism leading to reduced blood platelets remains unclear, although an unrestrained megak...
Interplay of leucocyte-platelet complexes and clinical response to eltrombopag in immune thrombocytopenia patients [0.03%]
血小板白细胞复合体与艾曲波帕治疗免疫性血小板减少症患者临床反应之间的关系
Rubén Osuna-Gómez,Carlos Zamora,Silvana Novelli et al.
Rubén Osuna-Gómez et al.
Eltrombopag (ELT) is a thrombopoietin-receptor agonist that stimulates platelet (PLT) production in patients with primary immune thrombocytopenia (ITP). One potential mechanism of ELT is modulating the inflammatory response by increasing PL...
Authors reply to direct oral anticoagulants in thrombotic anti-phospholipid syndrome: Addressing misinterpretations in subgroup analysis [0.03%]
抗磷脂综合征直接口服抗凝药的作者回应：亚组分析误读纠正
Deepa J Arachchillage,Sean Platton,Kieron Hickey et al.
Deepa J Arachchillage et al.
Real-world use of venetoclax in the treatment of paediatric and teenage/young adult haematological malignancies [0.03%]
维奈克拉在儿科及青少年和年轻成人血液系统恶性肿瘤治疗中的应用
Abbie Wilson,Ahmed Moussa,Amélie Trinquand et al.
Abbie Wilson et al.
Early-phase trials of venetoclax in children and teenagers/young adults with leukaemia have yielded promising results, but there remains a paucity of real-world data. To address this, we report a cohort of 41 children treated with venetocla...
Deferasirox, an iron chelator, impacts myeloid differentiation by modulating NF-kB activity via mitochondrial ROS [0.03%]
铁螯合剂Deferasirox通过线粒体ROS调节NF-κB活性从而影响髓系分化
Nathan E Jeffries,Daniel Sadreyev,Elizabeth C Trull et al.
Nathan E Jeffries et al.
The iron chelator deferasirox (DFX) is effective in the treatment of iron overload. In certain patients with myelodysplastic syndrome, DFX can also provide a dramatic therapeutic benefit, improving red blood cell production and decreasing t...
Time to lymphoma treatment within 24 months in 'watch and wait' follicular lymphoma is associated with inferior outcomes: A multicentre analysis [0.03%]
对初诊即采用“观察等待”策略的滤泡性淋巴瘤患者而言，确诊后两年内接受治疗与较差的预后相关：一项多中心分析研究
Jing Liu,Fenghua Gao,Tingting Zhang et al.
Jing Liu et al.
Some 'watch and wait' (W&W) FL patients suffer from rapid progression in a short term. Herein, we sought to identify these patients and also develop a risk score to screen them at diagnosis. Between 2008 and 2022, a total of 411 FL patients...
Multicenter Study
British journal of haematology. 2024 Nov;205(5):1815-1824. DOI:10.1111/bjh.19770 2024
Impaired microvascular function in patients with sickle cell anemia and leg ulcers improved with healing [0.03%]
溶血性贫血患者的微血管功能损伤与愈合改善的关系研究
Judith Catella,Etienne Turpin,Philippe Connes et al.
Judith Catella et al.
Leg Ulcer (LU) pathophysiology is still not well understood in sickle cell anaemia (SCA). We hypothesised that SCA patients with LU would be characterised by lower microvascular reactivity. The aim of the present study was to compare the mi...