Alexander M M Eggermont
Alexander M M Eggermont
Immunotherapy of melanoma [0.03%]
黑色素瘤的免疫治疗
John B A G Haanen
John B A G Haanen
Melanoma is considered one of the immunogenic - if not the most immunogenic - malignancies. This is based on several observations.1.Spontaneous remissions occur occasionally.2.In about 5% of melanomas no primary tumour is found. The genetic...
Targeted therapy in melanoma - the role of BRAF, RAS and KIT mutations [0.03%]
黑色素瘤的靶向治疗-BRAF、RAS和KIT突变的作用
Simone M Goldinger,Carla Murer,Pascale Stieger et al.
Simone M Goldinger et al.
Melanoma today is considered as a spectrum of melanocytic malignancies characterised by clinical and molecular features, including targetable mutations in several kinases such as BRAF or c-KIT. The successful development of therapies target...
R G Orsini,T Wiggers,M C DeRuiter et al.
R G Orsini et al.
Rob Glynne-Jones,Ian Chau
Rob Glynne-Jones
Neoadjuvant treatment in terms of preoperative radiotherapy reduces local recurrence in rectal cancer, but this improvement has little if any impact on overall survival. Currently performed optimal quality-controlled total mesorectal excisi...
Doenja M J Lambregts,Regina G H Beets-Tan
Doenja M J Lambregts
Philip Poortmans
Philip Poortmans
Radiation therapy significantly reduces by at least 70% the relative risk of local and regional recurrences for breast cancer after surgery. A positive influence on overall survival has been clearly demonstrated, especially for patients wit...
Angelo Paolo Dei Tos
Angelo Paolo Dei Tos