Relative bioavailability of 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) in rats and monkeys [0.03%]
4,4'-二羟基苯并茋酮-2,4-二硝基苯胲腙(A-007)的相对生物利用度(大鼠和猴)
S Subramasnian,A H Rodgers,L R Morgan et al.
S Subramasnian et al.
4,4'-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) is being evaluated for its anticancer activities in melanoma, breast cancer, Kaposi's sarcoma and lymphoproliferative disorders. A single oral dose of 1 g/kg of A-007 in rats res...
Comparative Study
Journal of experimental therapeutics & oncology. 1996 Jan;1(1):62-5. DOI: 1996
Ultrastructural changes related to multidrug resistance in CEM cells: role of cytoplasmic vesicles in drug exclusion [0.03%]
与多药耐药相关的CEM细胞的超微结构变化：胞浆膜囊在药物排出中的作用
H Bobichon,M Colin,C Depierreux et al.
H Bobichon et al.
The multidrug resistance phenotype is found to be frequently associated with the overexpression of proteins which lead to a decrease of drug accumulation within human tumor cells. A 170 kDa membrane glycoprotein which is related to the over...
Messenger RNA expression of resistance factors in human tumor cell lines after single exposure to radiation [0.03%]
人肿瘤细胞系单次照射后抗性因素的mRNA表达式量变化研究
G Stammler,E W Pommerenke,U Masanek et al.
G Stammler et al.
Resistance of tumor cells to chemotherapeutic drugs can not only be caused by treatment with antineoplastic agents but also by radiotherapy. The aim of this study was to analyze whether ionizing radiation can influence the mRNA expression o...
Rates of development of methotrexate resistance in heterogeneous mouse mammary tumor cell cultures [0.03%]
异质性小鼠乳腺肿瘤细胞培养中甲氨蝶呤抗性的进化速率
B E Miller,L H Matherly,M Lehotan et al.
B E Miller et al.
Our previous studies have indicated that the expression by tumor cells of sensitivity to chemotherapeutic drugs such as methotrexate can be affected by the presence of other tumor cells; thus, otherwise methotrexate-resistant cells may resp...
In vivo reversibility of multidrug resistance by the MDR-modulator dexniguldipine (niguldipine derivative B859-35) and by verapamil [0.03%]
钙通道阻滞剂衍生物B859-35和维拉帕米在体内的抗多药耐药作用的可逆性研究
M Dietel,H Boss,A Reymann et al.
M Dietel et al.
The newly synthesized dihydropyridine derivative B859-35 was previously shown in vitro to be highly effective in reversing multidrug resistance (MDR) of P-glycoprotein positive tumor cell lines, such as the adriamycin (ADR) resistant erythr...
Multidrug resistance-modifying components in human plasma with potential clinical significance [0.03%]
具有潜在临床意义的人体血浆多药耐药改性成分
H S Mülder,H M Pinedo,A T Timmer et al.
H S Mülder et al.
P-Glycoprotein (P-gp) and multidrug resistance protein (MRP) are plasma membrane associated proteins which can confer multidrug resistance (MDR) to cancer cells by lowering the intracellular amount of drug. Although clinical trials with MDR...
Clinical Trial
Journal of experimental therapeutics & oncology. 1996 Jan;1(1):13-22. DOI: 1996
Expression of cyclin D1, CDK4 and p27KIP1 is associated with the p16MTS1 gene status in human esophageal carcinoma cell lines [0.03%]
人食管癌细胞系中cyclin D1，CDK4和p27KIP1的表达与p16 MTS1基因状态有关
K Kitahara,W Yasui,H Yokozaki et al.
K Kitahara et al.
p16MTS1/INK4A negatively regulates cell cycle progression by inhibiting the cyclin D/CDK4 complex that phosphorylates pRb. Frequent homozygous deletions of the p16 gene were recently found in various tumor cell lines. We examined the relati...