The success of locoregional, low-dose recombinant interleukin-2 therapy in tumor-bearing mice is dependent on the time of rIL-2 administration [0.03%]
肿瘤荷瘤小鼠局部低剂量rhIL-2治疗成功的时机依赖性研究
L A Everse,M R Bernsen,H F Dullens et al.
L A Everse et al.
The extremely different administration schedules that are used in testing recombinant interleukin-2 (rIL-2) therapies for cancer may account for the extreme variation in efficacy reported in various studies in animal models. A major point m...
Modulation of chemosensitivity by alpha interferon in multiple myeloma and non-Hodgkin's lymphoma [0.03%]
干扰素α对多发性骨髓瘤和非霍奇金淋巴瘤化学敏感性的调节作用
R V Iaffaioli,G Facchini,A Tortoriello et al.
R V Iaffaioli et al.
Low-grade non-Hodgkin's lymphoma and multiple myeloma are chemosensitive malignancies, but are rarely curable because of primary or acquired drug resistance. Interferon has been shown to modulate the multidrug resistance phenotype and to re...
Clinical Trial
Journal of experimental therapeutics & oncology. 1996 Jul;1(4):226-30. DOI: 1996
Ultrastructural study of the urothelial lysosomal system in patients with transitional cell carcinoma after transurethral resection and interferon therapy [0.03%]
经尿道切除并干扰素治疗后过渡细胞癌患者膀胱移行上皮溶酶体系统的超微结构观察研究
P Stravoravdi,K Natsis,P Kirtsis et al.
P Stravoravdi et al.
The epithelial cells of human bladder urothelium contain a prominent lysosomal system on the surface layer which involves autophagic, phagocytotic and excretory processes. The noninvolved urothelium of tumor-bearing patients, however, does ...
Clinical Trial
Journal of experimental therapeutics & oncology. 1996 Jul;1(4):222-5. DOI: 1996
Modulation of chemosensitivity in human colon carcinoma cells by downregulating protein kinase C alpha expression [0.03%]
下调蛋白激酶Cα表达对人结肠癌细胞化学敏感性调节的影响研究
S Chakrabarty,S Huang
S Chakrabarty
Protein kinase C (PKC) is thought to play a role in tumor progression and drug resistance of colon carcinomas. Specifically, the PKC alpha isoform has been implicated in drug resistance and responsiveness of colon carcinoma cells to growth ...
Chemopreventive efficacy of selenomethionine and its role in the antioxidant defense system in 2-acetylaminofluorene-induced hepatocarcinogenesis in rats [0.03%]
硒代蛋氨酸的化学预防效果及其在2-乙酰氨基芴致肝癌发生过程中抗氧化防御系统中的作用
B Mukherjee,S Ghosh,M Chatterjee
B Mukherjee
Drinking water supplemented with selenium (8 ppm, daily) has been found to be highly effective in reducing tumor incidence and preneoplastic foci in 2-acetylaminofluorene (2-AAF) induced hepatocarcinogenesis in Sprague-Dawley male rats. Glu...
Studies on the mechanism of action of 1-beta-D-arabinofuranosyl-5-azacytosine (fazarabine) in mammalian lymphoblasts [0.03%]
关于1--D--阿拉伯糖呋喃硫酸盐--5--氮杂胞苷（法扎拉滨）在哺乳动物淋巴细胞中的作用机制的研究
J J Barchi Jr,D A Cooney,G S Ahluwalia et al.
J J Barchi Jr et al.
Fazarabine has shown activity in the panel of 60 cultured human tumor lines of the National Cancer Institute. COMPARE analyses relating correlation coefficients of other anticancer drugs with those of fazarabine suggest that this agent oper...
A phase II trial of paclitaxel in the treatment of recurrent or metastatic soft tissue sarcomas or bone sarcomas [0.03%]
紫杉醇治疗复发或转移性软组织肉瘤或骨肉瘤的II期临床试验
V G Gian,T J Johnson,R W Marsh et al.
V G Gian et al.
The study aimed to determine the activity and toxicity of taxol in the treatment of recurrent or metastatic soft tissue sarcomas or osteosarcomas. The major findings are that five patients had stable disease after two cycles of chemotherapy...
Comparison of triple helix formation by polypurine versus polypyrimidine oligodeoxynucleotides when conjugated to a DNA intercalator [0.03%]
带DNA嵌入剂的聚嘌呤型和聚嘧啶型寡核苷酸三链形成能力的比较分析
F M Orson,J Klysik,G A Glass et al.
F M Orson et al.
Biological applications of triplex forming oligonucleotides will require the development of oligomers with high avidity and specificity. We examined the binding enhancement resulting from intercalator conjugation to both parallel design (po...
Comparative Study
Journal of experimental therapeutics & oncology. 1996 May;1(3):177-85. DOI: 1996
Phytohemagglutinin-induced gut hyperplasia and the growth of a mouse lymphosarcoma tumor [0.03%]
植物血凝素诱发的肠道增生与小鼠淋巴瘤肿瘤生长之间的关系
I F Pryme,A J Pusztai,G Grant et al.
I F Pryme et al.
NMRI mice injected subcutaneously with Krebs II lymphosarcoma cells and fed on a diet containing the kidney bean lectin phytohemagglutinin (PHA) within the range 0.45-7.0 mg/g diet, developed tumors during a 10 day period which on average w...
T Hiwasa,H Tokita,Y Ike
T Hiwasa
The effects of anticancer drugs on cell growth have been investigated by MTT colorimetric assay using mouse and rat cultured cells transformed by various oncogenes and tumor viruses. Aclarubicin, mitomycin C and 1-hexylcarbamoyl-5-fluoroura...