Antitumoral activity of a new series of 5,6-dihydrobenzo(a)carbazoles [0.03%]
一系列5,6-二氢苯并(a)卡唑的抗肿瘤活性
Gabriela Martin,Claudia Cocca,Elena Rivera et al.
Gabriela Martin et al.
The overlapping of three-dimensional structures of 5,6-dihydrobenzo(a)carbazole (DHBC) derivatives over the structure of 4-hydroxytamoxifen (4-OH-TAM), by means of the MDL CHEMLAB 11.0 computational program, shows a reasonable structural an...
Tissue reactions after long-term intracerebral implantation of three different types of biodegradable polylactide rods in the rat [0.03%]
三种可降解聚乳酸棒状物长时期颅内植入后的大鼠组织反应
Jürgen Voges,Ralph Lehrke,Don Gyu Kim et al.
Jürgen Voges et al.
Purpose: To investigate acute and late tissue reactions following intracerebral implantation of three different biodegradable DL-polylactids: Resomer R104 + R203 (1 + 1) (SU48), Resomer R203 (SU49), and DL-polylactid-co-t...
Parameters affecting the ex vivo cytotoxic drug sensitivity of human hematopoietic cells [0.03%]
影响人造血细胞体外细胞毒药物敏感性的参数分析
Andrew G Bosanquet,Alison R Burlton,Philip B Bell
Andrew G Bosanquet
The drug sensitivity of normal cells provides a baseline for determining the therapeutic index, and therefore the effectiveness, of cytotoxic drugs, yet little is known about the factors that affect normal cell chemosensitivity. Some parame...
Recombinant human interleukin-3 administered concomitantly with chemotherapy in patients with relapsed small cell lung cancer [0.03%]
与化疗联合使用重组人白细胞介素-3治疗复发的小细胞肺癌患者
Bonne Biesma,Klaas W van Kralingen,Rob W van Leen et al.
Bonne Biesma et al.
Although recombinant human interleukin-3 (rhIL-3) shortens both the duration of chemotherapy-induced neutropenia and thrombocytopenia, its effect on nadir counts is limited. Concurrent administration of rhIL-3 and chemotherapy may enhance t...
In vivo advantage of combined administration with CPT-11 and 5-fluorouracil in rats [0.03%]
伊立替康与氟尿嘧啶联用的体内增效作用研究
Hiroaki Satoh,Masao Ohtomo,Hiroichi Ishikawa et al.
Hiroaki Satoh et al.
In vivo effect of a bolus combination with 5-fluorouracil (5-FU) and CPT-11 was studied against experimental rat lung cancer, SLC cells. 5-FU and CPT-11, when administrated individually, showed dose-dependent inhibition against the tumor (I...
Modulation of multidrug resistance in human ovarian cancer cell lines by inhibition of P-glycoprotein 170 and PKC isoenzymes with antisense oligonucleotides [0.03%]
反义寡核苷酸抑制P-糖蛋白170和PKC异构酶逆转人卵巢癌细胞株多药耐药性研究
Ulrike Masanek,Gerd Stammler,Manfred Volm
Ulrike Masanek
Multidrug resistance in human ovarian carcinoma cell lines is caused by the expression of several related proteins, namely P-glycoprotein 170 (Pgp-170), glutathione S-transferase-pi GST-pi), and thymidylate synthase (TS). These proteins see...
Interleukin-1 alpha increases the cytotoxic activity of etoposide against human osteosarcoma cells [0.03%]
白细胞介素-1 alpha增强依托泊苷对人骨肉瘤细胞的细胞毒作用
Shu-Fang Jia,Leonard A Zwelling,Amanda McWatters et al.
Shu-Fang Jia et al.
The recurrence of pulmonary metastases resistant to salvage chemotherapy continues to be a major problem in osteosarcoma patients. Our goal is to identify novel combinations of biologic response modifiers plus chemotherapeutic agents that c...
Augmentation of apoptosis by the combination of bleomycin with trifluoperazine in the presence of mutant p53 [0.03%]
曲古丙氧酚与博莱霉素联用并通过突变型p53促进凋亡的作用
Gregory F Sullivan,Adrienne Garcia-Welch,Eileen White et al.
Gregory F Sullivan et al.
A variety of anticalmodulin drugs can increase the cytotoxicity of bleomycin, a DNA damaging cancer chemotherapeutic. The combination has been shown to produce greater than expected DNA damage compared wot what was observed with either drug...
Loss of heterozygosity and microsatellite instability in epithelial hyperplasia of the breast [0.03%]
乳腺上皮增生的异倍体丢失和微卫星不稳定现象分析
Mayumi Kaneko,Koji Arihiro,Yukio Takeshima et al.
Mayumi Kaneko et al.
We evaluated loss of heterozygosity (LOH) and microsatellite instability (MSI) in epithelial hyperplasia of the breast by the PCR method using microsatellite markers. Seven loci of 16q, 17p, 17q, and 18q were examined in 35 lesions of epith...
The effect of TNP-470 on cell proliferation and urokinase-type plasminogen activator and its inhibitor in human lung cancer cell lines [0.03%]
TNP-470对人肺癌细胞系增殖及尿激酶型血浆纤溶酶原激活物及其抑制剂的影响
H Ishikawa,H Satoh,H Kamma et al.
H Ishikawa et al.
The plasminogen activator system has been found to modulate neoplastic spread and angiogenesis in tumors. An angiogenesis inhibitor, TNP-470, has been shown to possess potent antitumor activities in various types of cancer cells. We therefo...