Use of microdialysis to study platinum anticancer agent pharmacokinetics in preclinical models [0.03%]
微透析技术在铂类抗肿瘤药物药动学研究中的应用
Mary J Johansen,Neil Thapar,Robert A Newman et al.
Mary J Johansen et al.
Microdialysis sampling of blood and extracellular fluid (ECF) of living tissue offers unique advantages for studying anticancer drug distribution, metabolism, and mechanisms of tumor drug resistance. We applied microdialysis sampling in a r...
Guadalupe Palencia,Oscar Arrieta,Camilo Ríos et al.
Guadalupe Palencia et al.
This study investigated the effects of chronic administration of thalidomide on three different neoplasms of ectodermic origin in rodents: 1) chemically induced tumors of the nervous system of rats by transplacental exposure to ethylnitroso...
Lymphocyte activation by granulocyte macrophage-colony stimulating factor in human bladder cancer [0.03%]
人膀胱癌中粒细胞-巨噬细胞集落刺激因子对淋巴细胞的活化作用
Toliou Theano,Stravoravdi Pelagia,Natsis Konstantinos et al.
Toliou Theano et al.
Objectives: The goal of this study was to investigate the ablative or reductive activity of granulocyte macrophage-colony stimulating factor (GM-CSF) instillations on transitional cell carcinoma marker lesions as well as ...
P-glycoprotein expression by cancer cells affects cell cytotoxicity and cell-cycle perturbations induced by six chemotherapeutic drugs [0.03%]
癌细胞中p糖蛋白的表达影响六种化疗药物诱导的细胞毒性和细胞周期紊乱
Carlos M Galmarini
Carlos M Galmarini
Background: P-glycoprotein (P-gp)-mediated chemoresistance plays an important role in drug resistance. Methods: We investigated if P-gp...
Human chorionic gonadotropin (hCG), the hormone of life and death: a review [0.03%]
生命与死亡的激素——人绒毛膜促性腺激素（hCG）：综述
Hernan F Acevedo
Hernan F Acevedo
p53 expression, growth, and spontaneous metastasis of the human GI 101 breast carcinoma in athymic nude mice [0.03%]
人GI 101乳腺癌的P53表达、生长及裸鼠的自发转移现象
Sayed S Daoud,Charles W Leathers,Josephine M Hurst
Sayed S Daoud
The human GI 101 breast carcinoma cell lines produces spontaneous metastasis to the lungs when xenografted subcutaneously in female athymic nude mice. To establish the time-course of tumor growth and distant metastasis to the lungs and axil...
Identification of two distinct intracellular sites that contribute to the modulation of multidrug resistance in P388/ADR cells expressing P-glycoprotein [0.03%]
在表达P-糖蛋白的P388/ADR细胞中鉴定出两个不同的胞内位点参与多药耐药性的调节
Lawrence D Mayer,Kye-Taek Lim,Daria Hartley
Lawrence D Mayer
Although the ability of chemosensitizers to modulate P-glycoprotein (PGP)-based multidrug resistance (MDR) has been extensively studied, relatively little is known about the cellular pharmacology of the PGP inhibitors themselves in MDR cell...
Adenovirus-mediated tissue-specific cytosine deaminase gene therapy for human hepatocellular carcinoma with different AFP expression levels [0.03%]
腺病毒介导的组织特异性胞苷脱氨酶基因治疗不同AFP表达水平的人肝癌干细胞移植小鼠肿瘤异种移植模型
Xin Huang,Weiping Zhang,Hiroaki Wakimoto et al.
Xin Huang et al.
To evaluate whether in vitro and in vivo transferring of Escherichia coli cytosine deaminase gene to a solid tumor will confer the sensitivity to the prodrug 5-fluorocytosine (5FC) on these cells, we constructed two replication-defective ad...
Capacity of murine IL-12 to inhibit the development of primary melanoma tumors and to prevent lung metastases in the melanoma-challenged mice [0.03%]
小鼠IL-12抑制原发性黑素瘤肿瘤的发展并预防对黑素瘤的肺转移的能力
David P Shrayer,Hendrik Bogaars,Bernard Cole et al.
David P Shrayer et al.
Interleukin-12 (IL-12) has the capacity to activate cytotoxic lymphocytes, stimulate natural killer cells, induce the production of INF-gamma, and be synergistic with IL-2. We have evaluated this cytokine in an experimental model for metast...
Effects of hexadecylphosphocholine on phosphatidylcholine and phosphatidylserine metabolism in human lymphoma cells [0.03%]
十六烷基磷胆碱对人淋巴瘤细胞中卵磷脂和脑磷脂代谢的影响
Dinko Berkovic,Sabine Sievers,Detlef Haase et al.
Dinko Berkovic et al.
Hexadecylphosphocholine (HePC) belongs to a new group of antineoplastic agents, the alkylphosphocholines (APC). HePC shows a broad spectrum of biological effects in various cells in vitro and in vivo. It has pronounced antiproliferative eff...