Murine pharmacokinetics and metabolism of oleandrin, a cytotoxic component of Nerium oleander [0.03%]
夹竹桃毒毛旋花子苷在小鼠体内的药代动力学和代谢研究
Dan Ni,Timothy L Madden,Mary Johansen et al.
Dan Ni et al.
Pharmacokinetic studies of [3H]oleandrin, a cardiac glycoside component of Anvirzel, were conducted in mice after either an i.v. dose (40 micrograms/kg) or a p.o. dose (80 micrograms/kg). Oleandrin was rapidly absorbed after oral dosing (Cm...
Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells [0.03%]
叶酸限制导致细胞内叶酸池的枯竭和组成变化，使甲氨蝶呤和三甲氧苄氨嘧啶的敏感性中度增加、内源性二氢叶酸还原酶活性上调以及金属硫蛋白II和叶酸受体α过表达，并在重新补充叶酸时赋予CHL细胞耐药性
Wei-Yong Zhu,M Bunni,D G Priest et al.
Wei-Yong Zhu et al.
DC-3F/FA3 cells (FA3) were derived from antifolate-sensitive CHL cells by selection for growth in folate-free media containing 15 pM [6S]-5CHOFH4. These cells undergo a 30-fold decrease in intracellular folates, overexpress folate receptor ...
Balanehru Subramanian,Alexander Nakeff,Joseph Media et al.
Balanehru Subramanian et al.
The cellular paradigm presented here defines the cellular action profile of new anticancer agents that complements our discovery and development paradigm. The main elements of this profile include a concentration clonogenicity response rela...
Src protein kinase pp60c-src influences adhesion stabilization of HT-29 colon carcinoma cells to extracellular matrix components under dynamic conditions of laminar flow [0.03%]
Src蛋白激酶pp60c-src影响层流条件下HT-29结肠癌细胞与细胞外基质成分相互作用的稳定性
Jörg Haier,Garry E Gallick,Garth L Nicolson
Jörg Haier
Tumor cell adhesion to extracellular matrix (ECM) and its stabilization are important determinants in metastasis formation, and they are mediated, in part, by integrins and regulated by a variety of protein kinases. Protein tyrosine kinase ...
Fred Valeriote,Charles K Grieshaber,Joseph Media et al.
Fred Valeriote et al.
A novel in vitro assay for the discovery of anticancer agents was used to examine aqueous and organic extracts from 1847 plants collected mainly in the U.S. Southwest and West. The assay results were separated into 5 categories: inactive (6...
In vivo antitumor activity of F 11782, a non-intercalating dual catalytic inhibitor of topoisomerases I and II, against a panel of human tumor xenografts [0.03%]
F11782（一种非嵌入型拓扑异构酶I和II双重催化抑制剂）对一组人体肿瘤移植瘤的体内抗肿瘤活性作用研究
A Kruczynski,C Ricome,W R Waud et al.
A Kruczynski et al.
The marked in vivo antitumor activity of F 11782 against murine experimental tumors (Kruczynski et al., Br J Cancer 83: 1516-24, 2000) has now been confirmed in a panel of human tumor xenografts. Using an intermittent schedule of six admini...
Hexadecylphosphocholine does not influence phospholipase D and sphingomyelinase activity in human leukemia cells [0.03%]
十六烷基磷胆碱不影响人类白血病细胞中的磷脂酶D和鞘氨醇磷酸酶活性
Dinko Berkovic,Katharina Berkovic,Claudia Binder et al.
Dinko Berkovic et al.
Hexadecylphosphocholine (HePC) is the first representative of the alkylphosphocholines (APC), a new group of biologically active compounds. HePC has pronounced antiproliferative effects on neoplastic cells in vitro and in vivo. The molecula...
Correlation of nucleoside and nucleobase transporter gene expression with antimetabolite drug cytotoxicity [0.03%]
核苷和碱基转运蛋白基因表达与抗代谢药物细胞毒性的相关性
Xin Lu,Shimei Gong,Anne Monks et al.
Xin Lu et al.
Antimetabolite drugs that inhibit nucleic acid metabolism are widely used in cancer chemotherapy. Nucleoside and nucleobase transporters are important for the cellular uptake of nucleic acids and their corresponding anticancer analogue drug...
Inhibitory effect of vitamin D3 on 3'methyl-4-dimethyl-amino-azobenzene-induced rat hepatocarcinogenesis: a study on antioxidant defense enzymes [0.03%]
维生素D3对肝癌的抑制作用及对抗氧化防御酶的影响研究
Ranajit Karmakar,Sarmistha Banik,Malay Chatterjee
Ranajit Karmakar
The anticarcinogenic effect of vitamin D3 (VD3) on 3,-methyl-4-dimethyl-amino-azobenzene (3,-Met-DAB)-induced hepatocarcinogenesis was investigated in male Sprague-Dawley rats. Anticancer efficacy of VD3 was estimated using different possib...
Qing Zeng,Peter M Kanter,Rajiv Dhir et al.
Qing Zeng et al.
Purpose: EGFR is overexpressed in many human cancer cells, including head and neck squamous cell carcinoma (HNSCC). We have previously shown that elevated EGFR levels in the primary HNSCC tumor are associated with decreas...