Superinduction of P-glycoprotein messenger RNA in vivo in the presence of transcriptional inhibitors [0.03%]
Chow H Lee,Victor Ling
Chow H Lee
P-Glycoprotein (P-gp) is comprised of a small family of plasma membrane proteins, and its presence in high amounts often correlates with multidrug resistance in cultured cells. Dramatically increased levels of a single member of P-gp mRNA (...
John A Kellen
John A Kellen
Epigallocatechin-3-gallate decreases VEGF production in head and neck and breast carcinoma cells by inhibiting EGFR-related pathways of signal transduction [0.03%]
表没食子儿茶素没食子酸酯通过抑制信号转导上的EGFR相关途径来减少头颈部和乳腺癌细胞中的VEGF生成
Muneyuki Masuda,Masumi Suzui,Jin T E Lim et al.
Muneyuki Masuda et al.
In a recent study on head and neck squamous cell carcinoma (HNSCC) cells we found that epigallocatechin-3-gallate (EGCG), a major biologically active component of green tea, inhibited activation of the epidermal growth factor receptor (EGFR...
Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice [0.03%]
局部给药IL-12基因修饰的树突状细胞诱导肝转移肠腺癌的小鼠抗肿瘤免疫应答
Yuji Satoh,Clemens Esche,Andrea Gambotto et al.
Yuji Satoh et al.
Colorectal cancer is one of the most common fatal malignancies in the United States, with an incidence second only to lung cancer. The liver is the most common site of colorectal metastases and frequently the only affected organ once the pr...
Hexadecylphosphocholine selectively upregulates expression of intracellular adhesion molecule-1 and class I major histocompatibility complex antigen in human monocytes [0.03%]
十六烷基磷胆碱选择性上调人单核细胞的细胞间粘附分子-1和Ⅰ类主要组织相容性复合物抗原的表达
Ines Eue
Ines Eue
U 937 cells are widely used as a model system to study human monocytes, since they express typical human monocyte markers and properties. Hexadecylphosphocholine (HPC) is the main representative of a class of synthetic phospholipids, the al...
A phase I trial of depsipeptide (FR901228) in patients with advanced cancer [0.03%]
帕波肽治疗晚期癌症患者I期临床试验
John L Marshall,Naiyer Rizvi,John Kauh et al.
John L Marshall et al.
Depsipeptide (FR901228) is a bicyclic peptide isolated from Chromobacterium violaceum that has demonstrated potent in vitro cytotoxic activity against human tumor cell lines and in vivo efficacy against human tumor xenografts. The primary m...
Loss of growth factor sensitivity and development of mitoxantrone resistance in transplanted recurrent SA7HD myeloid leukemia [0.03%]
生长因子敏感性丧失和SA7HD复发型髓样白血病对米托蒽醌抗性的发育
Aminu A Abubakar
Aminu A Abubakar
Recurrent SA7HD leukemia cells have also "lost" the response to stimulation by L-929-conditioned medium (L-929-CM) and indeed were significantly insensitive to proliferative stimulation by combinations of WEHI-conditioned medium (WEHI-CM) a...
Gene therapy in cancer [0.03%]
癌症的基因治疗
John A Kellen
John A Kellen
Genetics have and will continue to have a strong and often controversial impact on our lives. Since the first human gene therapy in 1989, data from some 400 officially approved trials have been reported; only a handful appears promising. Of...
Enhancement of the antitumor effect of cyclophosphamide with the hypoxia-selective cytotoxin NLCQ-1 against murine tumors and human xenografts [0.03%]
NLCQ-1增强环磷酰胺抗肿瘤作用：对小鼠肿瘤和人源移植瘤的作用研究
Maria V Papadopoulou,Ming Ji,William D Bloomer et al.
Maria V Papadopoulou et al.
The antitumor effect of cyclophosphamide (CPM) was investigated against SCCVII murine tumors and PC-3 human xenografts in combination with the hypoxia-selective cytotoxin 4-[3-(2-nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochlor...
Type-1 transforming growth factor-beta differentially modulates tumoricidal activity of murine peritoneal macrophages against metastatic variants of the B16 murine melanoma [0.03%]
转化生长因子-β型不同调控小鼠腹腔巨噬细胞对B16黑色素瘤转移变体的杀伤活性
Dominic Fan,Amy Liaw,Yvonne M Denkins et al.
Dominic Fan et al.
Transforming growth factor-beta 1 (TGF-beta 1) renders mouse peritoneal macrophages tumoricidal against metastatic variants of the B16 mouse melanoma in vitro. Both direct cytotoxicity and indirect cytotoxicity were observed. A subthreshold...