Effects of amitriptyline and fluoxetine upon the in vitro proliferation of tumor cell lines [0.03%]
阿米替林和氟西汀对体外培养的肿瘤细胞系增殖的影响
Donna A Volpe,Christopher D Ellison,Ralph E Parchment et al.
Donna A Volpe et al.
Previous publications have suggested that commonly prescribed antidepressants have the potential to stimulate the proliferation of extant tumors in human and rodent in vivo and in vitro models. The direct effects of amitriptyline and fluoxe...
Low-dose total body irradiation augments the therapeutic effect of interleukin-2 in a mouse model for metastatic malignant melanoma [0.03%]
小剂量全身照射通过增强干扰素-2的疗效来抑制小鼠黑色素瘤肺转移
Akmal Safwat,Ninna Aggerholm,Ivan Roitt et al.
Akmal Safwat et al.
Background: Low-dose total body irradiation (LTBI) is known for its antitumor immune modulatory effects. Moreover, there is theoretical ground suggesting that combining LTBI with interleukin-2 (IL-2) will have a synergist...
Effects of combined in vivo treatment of transplantable solid mammary carcinoma in wistar rats using vitamin E and cysteine peptidase inhibitors from human placenta [0.03%]
维生素E和人胎盘半胱氨酸蛋白酶抑制剂联合作用于Wistar大鼠移植性乳腺实体癌的体内治疗作用研究
Yousif Saleh,Maciej Siewiñski,Tadeusz Sebzda et al.
Yousif Saleh et al.
Cysteine cathepsin B and its endogenous inhibitor play an important role in tumor progression. Increase in cathepsin B expression and reduced levels of its inhibitors were associated with tumor malignancy in breast cancer. The objective of ...
Exisulind and CP248 induce growth inhibition and apoptosis in human esophageal adenocarcinoma and squamous carcinoma cells [0.03%]
Exisulind和CP248诱导人食管腺癌和鳞状细胞癌的生长抑制和凋亡
Andrew K Joe,Hui Liu,Danhua Xiao et al.
Andrew K Joe et al.
We examined the effects of exisulind (sulindac sulfone) and a potent derivative CP248 on the Barrett's esophagus (BE)-related adenocarcinoma cell lines Seg-1 and Bic-1, and on HCE7 esophageal squamous carcinoma cells. Marked growth inhibiti...
Combined treatment of Bcl-2 antisense oligodeoxynucleotides (G3139), p-glycoprotein inhibitor (PSC833), and sterically stabilized liposomal doxorubicin suppresses growth of drug-resistant growth of drug-resistant breast cancer in severely combined immunodeficient mice [0.03%]
Bcl-2反义寡核苷酸(G3139)、p糖蛋白抑制剂(PSC833)及稳定脂质体阿霉素联合治疗可抑制严重免疫缺陷小鼠乳腺癌多药耐药肿瘤的生长
Daniel E Lopes de Menezes,Yanping Hu,Lawrence D Mayer
Daniel E Lopes de Menezes
We studied the possibility of increasing sensitization of drug-resistant MDA435/LCC6 multidrug-resistant (MDR) human breast cancer cells to doxorubicin (DOX) by increasing cellular drug retention with P-glycoprotein (P-gp) inhibitor PSC833 ...
In vitro analysis of the antileukemic effect of tumor necrosis factor-alpha gene therapy with myeloid progenitor cells: the role of dendritic cells [0.03%]
肿瘤坏死因子-α基因治疗与髓系祖细胞体外抗白血病作用的分析：树突状细胞的作用
Yong X Xu,Dorrah Deeb,Xiaohua Gao et al.
Yong X Xu et al.
We have previously demonstrated that tumor necrosis factor-alpha (TNF-alpha) gene therapy with transgene-expressing myeloid progenitor cells (32DTNF-alpha) is effective in inhibiting the progression of leukemia with a lethal dose of murine ...
Martin Zeller,Frank Essmann,Reiner U Jänicke et al.
Martin Zeller et al.
Radioactive assays are commonly employed to monitor protein or peptide phosphorylation. They not only have all the disadvantages related to radioactivity, but also require large amounts of sample. An alternative is the use of mass spectrome...
Metabolism of homoharringtonine, a cytotoxic component of the evergreen plant Cephalotaxus harringtonia [0.03%]
Dan Ni,Dah H Ho,Mary Vijjeswarapu et al.
Dan Ni et al.
Homoharringtonine (HHT), first isolated from the Chinese evergreen Cephalotaxus harringtonia, has been demonstrated to have a broad antitumor activity in rodents and antileukemic effects in humans. We found that HHT was metabolized to an ac...
Phosphatidylcholine-derived phosphatidic acid and diacylglycerol are involved in the signaling pathways activated by docetaxel [0.03%]
Nicolas Maestre,Christine Bezombes,Isabelle Plo et al.
Nicolas Maestre et al.
Taxanes are known to activate several cellular signals including mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-kappa B), tyrosine phosphorylation of Shc, and serine phosphorylation of Bcl-2. However, the mediators o...
Targeted prodrug treatment of HER-2-positive breast tumor cells using trastuzumab and paclitaxel linked by A-Z-CINN Linker [0.03%]
Carl W Gilbert,Eleanor B McGowan,Gerald B Seery et al.
Carl W Gilbert et al.
Targeting drugs for delivery and release has the potential to increase the efficacy of treatment. A bifunctional linker, A-Z-CINN Linker was used to create a targeted prodrug, A-Z-CINN 310. A-Z-CINN Linker links to a potent chemotherapeutic...