Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata [0.03%]
来自穿心莲的andrographolide是一种潜在的抗癌药物
Sriram Rajagopal,R Ajaya Kumar,Dhanvanthri S Deevi et al.
Sriram Rajagopal et al.
Andrographis paniculata plant extract is known to possess a variety of pharmacological activities. Andrographolide, the major constituent of the extract is implicated towards its pharmacological activity. We studied the cellular processes a...
Molecular identification and characterization of rat Abcc1 cDNA: existence of two splicing variants and species difference in drug-resistance profile [0.03%]
大鼠Abcc1基因的克隆、表达及两种剪接变异体的功能分析
Shin-Ichiro Takayanagi,Toshihisa Ishikawa
Shin-Ichiro Takayanagi
The human ABCC1 gene, a member of the ATP-binding cassette transporter super-family, plays a critical role in conferring cancer cell resistance to chemotherapeutic drugs. In the present study, we have cloned the full-length cDNA of rat Abcc...
Modulation of resistance to idarubicin by the cyclosporin PSC 833 (valspodar) in multidrug-resistant cells [0.03%]
环孢菌素PSC 833（伏泼托班）调节多药耐药细胞对伊达柔红霉素的耐受性
Norman J Lacayo,George E Duran,Branimir I Sikic
Norman J Lacayo
Idarubicin (IDA) is an anthracycline anticancer drug utilized in the treatment of acute leukemias. There are conflicting data published with regard to the cross-resistance of IDA in multidrug-resistant (MDR) cells expressing P-glycoprotein ...
Effects of regulatory domains of specific isoforms of protein kinase C on growth control and apoptosis in MCF-7 breast cancer cells [0.03%]
蛋白激酶C特定异构体调节区域对MCF-7乳腺癌细胞生长调控和凋亡的影响
Jae-Won Soh,Yun-Sil Lee,I Bernard Weinstein
Jae-Won Soh
Protein kinase C (PKC) is a multigene family consisting of at least 11 isoforms that play key roles in growth control and tumorigenesis. To understand the roles of specific isoforms of PKC in breast cancer, we generated derivatives of the h...
Darja Kanduc,Ferdinando Capuano,Sabrina A Capurso et al.
Darja Kanduc et al.
During the next years, molecular diagnostic science and the pharmaceutical industry will face increasing demand for personalized medicine. Therapeutic treatments should be tailored to the needs of individual patient. Patients will inquire f...
Modulation of antineoplastic activity of cyclophosphamide by Alstonia scholaris in the Ehrlich ascites carcinoma-bearing mice [0.03%]
喜树碱对喜马eland遏蓝花素模诱导的小鼠Ehrlich腹水癌抗新药活性的影响
Ganesh Chandra Jagetia,Manjeshwar Shrinath Baliga
Ganesh Chandra Jagetia
Alterations in the neoplastic activity of cyclophosphamide (CPA) by the extract of Alstonia scholaris(ASE) were studied in mice transplanted with Ehrlich ascites carcinoma (EAC). The tumor-bearing animals were injected with various doses of...
Chronomics: circadian and circaseptan timing of radiotherapy, drugs, calories, perhaps nutriceuticals and beyond [0.03%]
时间生物学在放射治疗、药物摄取、热量限制及可能的保健品中的应用：超越昼夜节律和七天周期的定时疗法
Franz Halberg,Germaine Cornélissen,Zhengrong Wang et al.
Franz Halberg et al.
We suggest a putative benefit from timing nutriceuticals (substances that are both nutrients and pharmaceuticals) such as antioxidants for preventive or curative health care, based on the proven merits of timing nutrients, drugs, and other ...
Subcutaneous interleukin-2 in combination with medroxyprogesterone acetate and antioxidants in advanced cancer responders to previous chemotherapy: phase II study evaluating clinical, quality of life, and laboratory parameters [0.03%]
有关先前化疗有效的晚期癌症患者的皮下注射干扰素2联合甲孕酮和抗氧化剂的II期临床研究及其对生活质量和实验室参数的影响
Giovanni Mantovani,Clelia Madeddu,Giulia Gramignano et al.
Giovanni Mantovani et al.
We carried out an open, non-randomized phase II study including all patients treated with whatever chemotherapy or combined modality regimen for whatever cancer who were in clinical objective response (complete response, CR, or partial resp...
siRNA agents inhibit oncogene expression and attenuate human tumor cell growth [0.03%]
小分子干扰 RNA抑制致癌基因表达并减弱人肿瘤细胞增殖功能
James Q Yin,Jingsong Gao,Ronguang Shao et al.
James Q Yin et al.
Cancer is a genomic functional disease with features of oncogene activation and tumor suppressor inactivation. These genomic features have resulted in the limited effectiveness of conventional therapies and therefore forced considerable eff...
Dinko Berkovic,Jan Heino Wernicke,Eduard A Fleer
Dinko Berkovic
Hexadecylphosphocholine and other etherlipid-derived substances show a pronounced antiproliferative activity on neoplastic cells and a broad spectrum of other biological effects on many cell types in vitro and in vivo. Though the precise mo...