Screening for small molecule inhibitors of insulin-like growth factor receptor (IGF-1R) kinase: comparison of homogeneous time-resolved fluorescence and 33P-ATP plate assay formats [0.03%]
胰岛素样生长因子受体（IGF-IR）激酶的小分子抑制剂的筛选：同功型时间分辨荧光与33P-ATP板测定格式的比较
Yan Wang,Michael Malkowski,Judith Hailey et al.
Yan Wang et al.
Insulin-like growth factor receptor 1 (IGF-1R) plays a critical role in oncogenic transformation (1). IGF-1R is overexpressed in some tumors including breast, lung, cervical, and Wilms' tumors (2-6). Upon binding of IGF-I or IGF-II, IGF-1R,...
Comparative Study
Journal of experimental therapeutics & oncology. 2004 Jul;4(2):111-9. DOI: 2004
Fatty acid synthase as a tumor marker: its extracellular expression in human breast cancer [0.03%]
长链脂肪酸合成酶作为肿瘤标记物在人乳腺癌中的细胞外表达
Young Y Wang,Francis P Kuhajda,Jinong Li et al.
Young Y Wang et al.
Overexpression of fatty acid synthase (FAS EC 2.3.1.85) is associated with certain cancers and therefore is a putative tumor marker. The presence of FAS in patients with breast, prostate, colon, ovarian, and other cancers has been reported....
Adipocyte-fatty acid binding protein induces apoptosis in DU145 prostate cancer cells [0.03%]
脂肪细胞-脂肪酸结合蛋白可诱导DU145前列腺癌细胞发生凋亡
Marta L De Santis,Rasha Hammamieh,Rina Das et al.
Marta L De Santis et al.
Adipocyte-fatty acid binding protein (A-FABP) is a 14-15 kDa cytoplasmic protein that binds unesterified fatty acids (FA). It is believed that A-FABP is present in normal cells and disappears in cancer cells. Prostate cancer DU145 cells lac...
Phase II study of OK-432 intrapleural administration followed by systemic cisplatin and gemcitabine for non-small cell lung cancer with pleuritis carcinomatosa [0.03%]
OK-432胸腔内注射联合全身化疗（顺铂+吉西他滨）治疗恶性胸腔积液非小细胞肺癌患者二期临床研究
Mizuki Ikehara,Fumihiro Oshita,Rie Suzuki et al.
Mizuki Ikehara et al.
We conducted a phase II study of OK-432 intrapleural administration followed by systemic chemotherapy using cisplatin with gemcitabine to determine their combined effects on non-small cell lung cancer (NSCLC) with pleuritis carcinomatosa. B...
Clinical Trial
Journal of experimental therapeutics & oncology. 2004 Apr;4(1):79-83. DOI: 2004
Selenium is effective in inducing lymphocyte progression through cell cycle in cancer patients: potential mechanisms for its activity [0.03%]
硒通过细胞周期促进癌症患者的淋巴细胞增殖：其活性的潜在机制
Giovanni Mantovani,Antonio Macciò,Clelia Madeddu et al.
Giovanni Mantovani et al.
Epidemiologic evidence in humans suggests a role for selenium in reducing cancer incidence and mortality. The aim of the present study was that to assess the ability of selenium dioxide (SeO2) to enhance the lymphocyte progression through t...
Immuno-neutralization of circulating relaxin does not alter the breast cancer-protective action of parity in MNU-treated rats [0.03%]
免疫中和循环松弛素不能改变MNU处理的大鼠产次的乳腺癌保护作用
Bernard G Steinetz,O David Sherwood,Sally Lasano et al.
Bernard G Steinetz et al.
Early pregnancy and childbirth protects women against future development of breast cancer by an unknown mechanism. Parity likewise reduces mammary cancer incidence in rats exposed to the carcinogen, N-methyl-N-nitrosourea (MNU), providing a...
Conditionally replicating adenoviruses as anticancer agents and ways to improve their efficacy [0.03%]
条件性复制的腺病毒作为抗癌药物及其疗效改善方法
Dinja Oosterhoff,Victor W van Beusechem
Dinja Oosterhoff
Conditionally replicating adenoviruses (CRAds) were developed as new tools for cancer therapy. CRAds specifically replicate in and kill cancer cells. Within a solid tumor mass, release of newly formed infectious particles from infected canc...
Transport of SN-38 by the wild type of human ABC transporter ABCG2 and its inhibition by quercetin, a natural flavonoid [0.03%]
人源ABCG2野生株介导SN-38的转运及其被天然黄酮类化合物槲皮素抑制的研究
Megumi Yoshikawa,Yoji Ikegami,Kazumi Sano et al.
Megumi Yoshikawa et al.
Irinotecan (CPT-11) is a widely-used potent anticancer drug that inhibits mammalian DNA topoisomerase I, however overexpression of the ATP-binding cassette transporter ABCG2 can confer cancer cells resistance to SN-38, the active form of CP...
A combination therapy with copper nicotinate complex reduces the adverse effects of 5-fluorouracil on patients with hepatocellular carcinoma [0.03%]
铜烟酸复合物联合疗法可减少5-氟尿嘧啶对肝细胞癌患者的不良影响
Muhammad A M El-Saadani
Muhammad A M El-Saadani
5-Fluorouracil (5-FU) as chemotherapy in cases of hepatocellular carcinoma (HCC), was found to initiate hepatotoxic injuries, ascites, leucopenia, thrombocytopenia and myelosupression that limit its use. Therefore, this work was conducted t...
Shea N Gardner,Michael Fernandes
Shea N Gardner
This review focuses on clinical trials and the approval process in order to understand the discrepancy between vibrant science and the continuing failure of mechanism-based anticancer drugs. ...