Molecular impacts of antisense complementary to the liver fatty acid binding protein (FABP) mRNA in DU 145 prostate cancer cells in vitro [0.03%]
反义寡核苷酸对前列腺癌DU145细胞内肝脏脂肪酸结合蛋白基因表达影响的体外研究
Rasha Hammamieh,Nabarun Chakraborty,Rina Das et al.
Rasha Hammamieh et al.
Previous studies in our laboratory have showed that liver (L)-FABP and intestine-FABP were upregulated in prostate cancer cells whereas Adipose-FABP and epidermal-FABP were down regulated in cancer cells when compared to normal cells in tis...
Determination of cysteine peptidases-like activity and their inhibitors in the serum of patients with ovarian cancer treated by conventional chemotherapy and vitamin E [0.03%]
常规化疗及维生素E治疗的卵巢癌患者血清中类似半胱氨酸蛋白酶活性及其抑制剂的测定
Maciej Siewinski,Yousif Saleh,Marian Gryboc et al.
Maciej Siewinski et al.
Enzymatic activity of cysteine peptidases (cathepsins B and L) --associated with carcinogenesis is controlled by their specific inhibitors. The study was objected to the effects enhanced by taxol and cisplatin in patients pretreated with th...
Therapeutic effects of Lycium barbarum polysaccharide (LBP) on mitomycin C (MMC)-induced myelosuppressive mice [0.03%]
枸杞多糖对丝裂霉素所致骨髓抑制小鼠的治疗作用研究
Gong Hai-Yang,Shen Ping,J I N Li et al.
Gong Hai-Yang et al.
Aim: To investigate the therapeutic effects of Lycium barbarum polysaccharide (LBP) on mitomycin C (MMC)-induced myelosuppressive mice. Methods: ...
Enhancement of photodynamic therapy by use of aminolevulinic acid/glycolic acid drug mixture [0.03%]
5-氨基乙酸/甘醇酸药膏混合物的光动力治疗效果研究
Piotr Ziolkowski,Beata J Osiecka,Gerhard Oremek et al.
Piotr Ziolkowski et al.
5-aminolevulinic acid (5-ALA) is a precursor in synthesis of endogenous porphyrins used to sensitize tumor tissues in photodynamic therapy (PDT). It is administered topically into a tumor which after the certain time, required for porphyrin...
CPI-0004Na, a new doxorubicin prodrug, reduces growth of 3LL-H61 carcinoma lung metastases in C57BI/6 mice [0.03%]
新型多柔比星前药CP0004Na可减少小鼠3LL-H61肺癌转移病灶的生长
Luc Dasnois,Karim Lebtahi,Jorge Abarca-Quinones et al.
Luc Dasnois et al.
The ETAP concept (Extracellularly Tumor-Activated Prodrug) is a new approach developed to overcome the lack of selectivity and the side effects responsible for the limited efficacy of chemotherapeutic agents. CPI-0004Na, a doxorubicin (Dox)...
Comparative Study
Journal of experimental therapeutics & oncology. 2004 Jul;4(2):167-9. DOI: 2004
Matteo Conti
Matteo Conti
A number of experimental evidences in cellular biology and pharmacology demonstrate that K+ channels are involved in the regulatory mechanisms of neoplastic cell proliferation and survival. Among the various types of K+ channels known so fa...
Genomic-wide cDNA microarray screening to correlate gene expression profile with chemoresistance in patients with advanced lung cancer [0.03%]
基因表达谱与晚期肺癌患者化疗耐药相关性的基因芯片筛选分析
Fumihiro Oshita,Mizuki Ikehara,Akiko Sekiyama et al.
Fumihiro Oshita et al.
We conducted a study using cDNA microarray analysis to determine whether expression levels of genes in tumors were correlated with tumor response to chemotherapy. Between September 2000 and December 2001, 47 patients were registered in the ...
Ex vivo therapeutic index by drug sensitivity assay using fresh human normal and tumor cells [0.03%]
基于人新鲜肿瘤和正常细胞的药物敏感性检测评估的体外安全窗大小
Andrew G Bosanquet,Philip B Bell
Andrew G Bosanquet
Toxicity is a major deterrent to achieving substantial improvements in cancer management, since most anticancer drugs inadequately distinguish normal and neoplastic tissues. Improving the differential between beneficial and toxic effects of...
Berberine sensitizes human glioma cells, but not normal glial cells, to ionizing radiation in vitro [0.03%]
小檗碱体外增强胶质瘤细胞而非正常脑细胞放射敏感性研究
Garret Yount,Yifang Qian,Dan Moore et al.
Garret Yount et al.
The identification of nontoxic agents that can enhance the efficacy of postoperative radiotherapy for patients with glioblastoma multiforme (GBM) remains a challenge in oncology. We evaluated human GBM cell lines for their responsiveness to...
Improving the toxicity profile of chemotherapy for advanced ovarian cancer: a potential role for CT-2103 [0.03%]
改善晚期卵巢癌化疗的毒性特征：CT-2103的潜在作用
Maurie Markman
Maurie Markman
Significant progress has been made in the management of advanced ovarian cancer. Response rates to platinum-based chemotherapy are respectable; however, recurrence continues to be the rule rather than the exception. Chemotherapy is administ...