Curcumin differentially sensitizes malignant glioma cells to TRAIL/Apo2L-mediated apoptosis through activation of procaspases and release of cytochrome c from mitochondria [0.03%]
姜黄素通过激活前胱冬酶和从线粒体释放细胞色素C诱导恶性胶质瘤细胞对TRAIL/Apo2L介导的细胞凋亡的敏感性不同研究
Xiaohua Gao,Dorrah Deeb,Hao Jiang et al.
Xiaohua Gao et al.
Malignant glioma cells are generally resistant or only weakly sensitive to tumor necrosis factor family of cell death-inducing ligands, including TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L. The chemopreventive activity of polypheno...
Differential proteomic serum pattern of low molecular weight proteins expressed by adenocarcinoma lung cancer patients [0.03%]
肺腺癌患者的低分子量蛋白质的差异性蛋白质组血清模式
Carla Mendes Maciel,Magno Junqueira,Marcos Eduardo Machado Paschoal et al.
Carla Mendes Maciel et al.
Based on the assumption that proteins can emanate from tumour to serum, we investigated whether serum low molecular weight proteins (LMW) can discriminate lung cancer patients from healthy donors. Pooled sera from 20 lung cancer patients ma...
Comparative Study
Journal of experimental therapeutics & oncology. 2005;5(1):31-8. DOI: 2005
Actin content and actin polymerization in hepatoma Morris 5123 tumor bearing rats after treatment with cysteine protease inhibitor and vitamin E [0.03%]
半胱氨酸蛋白酶抑制剂和维生素E对肝瘤小鼠.actin含量及多聚化作用的影响研究
Tadeusz Sebzda,Yousif Saleh,Maria Malicka-Blaszkiewicz et al.
Tadeusz Sebzda et al.
Aim: Actin microfilaments are components of cytoskeleton, the structure involved in many cellular functions, including cell motility, and morphology, its necessary for tumor progression and metastasis. We investigated the...
Antitumor activity of Nitronaphthal-NU, a novel mixed-function agent [0.03%]
新型多功能抗肿瘤药物Nitronaphthal-NU的抗肿瘤活性研究
Suva Samanta,Anindita Pain,Sushanta Dutta et al.
Suva Samanta et al.
Nitronaphthal-NU (Compound 1) was synthesized as a mixed-function antitumor agent based on the structures of the clinical drug CCNU and experimental compound Mitonafide. In vitro screening in four human tumor cell lines namely SNB-78 CNS, H...
Correlation between crystal violet dissolution assay and manual colony counting on the in vitro effects of Hsp90-inhibitors [0.03%]
结晶紫溶解度测定与手动菌落计数在体外Hsp90抑制剂效果的相关性研究
Hans-Joachim Ochel
Hans-Joachim Ochel
Radiobiological experiments routinely require the estimation of cellular survival. Several cytotoxicity assays have been proposed, which have inherent advantages and disadvantages. The performance of one of them, the crystal violet dissolut...
Comparative Study
Journal of experimental therapeutics & oncology. 2005;5(1):9-13. DOI: 2005
Characterization of polyclonal antibodies raised against a linear peptide determinant of desmoglein-3 [0.03%]
抗角蛋白颗粒层斑贴蛋白多克隆抗体的特征研究
Giovanni Angelini,Domenico Bonamonte,Mong-Shang Lin et al.
Giovanni Angelini et al.
Our labs are pursueing the goal of exactly defining the qualities of peptide antigenicity, immunogenicity and pathogenicity in order to develop safe specific immunotherapies by utilizing specific portions of disease-associated-proteins (DAP...
Phase II study of nedaplatin and irinotecan for elderly patients with advanced non-small cell lung cancer [0.03%]
奈达铂联合伊立替康治疗老年晚期非小细胞肺癌患者的Ⅱ期临床研究
Fumihiro Oshita,Kouzo Yamada,Haruhiro Saito et al.
Fumihiro Oshita et al.
We conducted a phase II study of combination chemotherapy with nedaplatin (NP) with irinotecan (CPT) to determine the effects against unresectable non-small cell lung cancer (NSCLC) and to determine the qualitative and quantitative toxiciti...
Clinical Trial
Journal of experimental therapeutics & oncology. 2004 Dec;4(4):343-8. DOI: 2004
Effect of arsenic trioxide (ATO) on human lung carcinoma PG cell line: ATO induced apoptosis of PG cells and decreased expression of Bcl-2, Pgp [0.03%]
三氧化二砷(ATO)对人肺腺癌PG细胞系的作用研究及机制探讨
Bo Han,Gengyin Zhou,Qinghui Zhang et al.
Bo Han et al.
Arsenic trioxide (ATO) has been established to be an effective agent for treating newly diagnosed and relapsed acute promyelocytic leukemia (APL) patients. Laboratory data suggest that ATO induces apoptosis of hematopoietic or several solid...
Carla Mendes Maciel,Marcos Eduardo Machado Paschoal,Márcia Tie Kawamura et al.
Carla Mendes Maciel et al.
Lung cancer is one of the leading causes of cancer deaths worldwide. The poor patients prognosis is largely attributable to the lack of effective early detection methods. Based on the concept that proteins and peptides can emanate from tumo...
Cyclooxygenase-2 induction and prostaglandin E2 accumulation in squamous cell carcinoma as a consequence of epidermal growth factor receptor activation by imatinib mesylate [0.03%]
甲磺酸伊马替尼通过表皮生长因子受体活化诱导鳞状细胞癌的环氧合酶-2和前列腺素E2的表达
Faye M Johnson,Peiying Yang,Robert A Newman et al.
Faye M Johnson et al.
Imatinib mesylate is a novel anti-tumor agent useful in the clinical management of chronic myelogenous leukemia and gastrointestinal stromal tumors with minimal toxicity relative to other forms of cancer therapy. Its clinical activity and m...