Darja Kanduc,Jan Geliebter,Alberta Lucchese et al.
Darja Kanduc et al.
Over the last century cancer research has produced data leading to a composite picture where gene mutations and epigenetic phenomena strictly relate and overlap. This complexity has repercussions on the anti-cancer therapeutical strategies....
Cathepsin D expression in human colorectal cancer: relationship with tumour type and tissue differentiation grade [0.03%]
人结直肠癌组织中猫泡素D的表达及其与肿瘤类型和分化等级的关系研究
Tadeusz Sebzda,Yousif Saleh,Jakub Gburek et al.
Tadeusz Sebzda et al.
Objective: Cathepsin D (CD) is one of the main proteolytic enzymes contributing to the development of cancer. The aim of this study was to CD activity assay in the homogenates of tissues from the centre of the tumour (0) ...
Expression patterns of fatty acid binding proteins in breast cancer cells [0.03%]
乳腺癌细胞中脂肪酸结合蛋白的表达模式
Rasha Hammamieh,Nabarun Chakraborty,Mohsen Barmada et al.
Rasha Hammamieh et al.
We studied the expression levels of fatty acid binding proteins in breast normal and cancer cell lines. Liver fatty acid binding protein (L-FABP) and intestine fatty acid binding proteins were shown to be up-regulated in breast cancer cell ...
Clinical role of determination of plasma mitotane and its metabolites levels in patients with adrenal cancer: results of a long-term follow-up [0.03%]
血浆密妥坦及其代谢产物浓度测定在肾上腺癌临床治疗中的作用：一项长期随访结果
Anna A Kasperlik-Zaluska,Andrzej Cichocki
Anna A Kasperlik-Zaluska
Our study aimed at evaluation of the relations between the plasma levels of mitotane (o,p'-DDD) and its metabolites, o,p'-DDA and o,p'-DDE, and the efficacy of Mitotane therapy during a long-term follow-up. Eighteen patients, aged 11 to 70 ...
Selection of cell lines with enhanced invasive phenotype from xenografts of the human prostate cancer cell line WPE1-NB26 [0.03%]
人前列腺癌细胞系WPE1-NB26异种移植瘤中选择侵袭性增强的细胞系
Amanda S Rivette,Erik J Tokar,Daniel E Williams et al.
Amanda S Rivette et al.
Prostate cancer is a leading cause of death from cancer in American men and metastasis the main cause of death. To better understand the disease and accelerate development of new therapies, in vivo models that reflect different disease stag...
Xianghui He,Tom C Tsang,Brain L Pipes et al.
Xianghui He et al.
The origin of cancer remains enigmatic. Current models of carcinogenesis based on the gene mutation hypothesis have limitations in explaining many aspects of cancer. We put forward a new model of multistage carcinogenesis and propose that c...
Chemosensitization of hormone-refractory prostate cancer cells by curcumin to TRAIL-induced apoptosis [0.03%]
姜黄素通过诱导化学敏感性使激素难治性前列腺癌细胞凋亡
Dorrah D Deeb,Hao Jiang,Xiaohua Gao et al.
Dorrah D Deeb et al.
Failure to undergo apoptosis has been implicated in the resistance of tumor cells to anticancer therapies. Promotion of apoptosis in tumor cells could potentially increase the efficacy of conventional treatment regimens and improve prognosi...
EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells [0.03%]
儿茶素通过抑制HER3活化和环氧合酶-2表达而抑制人类结肠癌细胞的生长
Masahito Shimizu,Atsuko Deguchi,Andrew K Joe et al.
Masahito Shimizu et al.
Increased expression of COX-2 appears to play an important role in the development of colorectal cancer. The level of COX-2 expression is regulated by various factors including activation of members of the EGFR family of RTKs. We previously...
Evaluation of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid as a novel therapy for solid tumors [0.03%]
评估分支链脂肪酸12-甲基十四酸作为实体瘤新型疗法的靶向动脉递送效果
Kenneth C Wright,Peiying Yang,Carolyn S Van Pelt et al.
Kenneth C Wright et al.
The purpose of this research was to evaluate the effects of targeted arterial delivery of the branched chain fatty acid 12-methyltetradecanoic acid (12-MTA) on the VX2 squamous cell carcinoma in rabbits. An intramuscular VX2 squamous cell c...
Expression of cystatin C in clinical human colorectal cancer tissues [0.03%]
临床结直肠癌组织中半胱氨酸蛋白酶抑制剂C的表达
Yousif Saleh,Tadeusz Sebzda,Maria Warwas et al.
Yousif Saleh et al.
We studied the relation between the antipapain activity of cysteine proteinase inhibitors (CPI) and immunohistochemical staining for cystatin C, using anti-chicken cystatin antibodies, in the colorectal cancer tissues. In primary tumour tis...